Aliases for ZNF572 Gene

Aliases for ZNF572 Gene

  • Zinc Finger Protein 572 2 3 4 5
  • FLJ38002 2
  • ZNF572 5

External Ids for ZNF572 Gene

Previous GeneCards Identifiers for ZNF572 Gene

  • GC08P125943
  • GC08P126054
  • GC08P121308
  • GC08P125985
  • GC08P124851

Summaries for ZNF572 Gene

GeneCards Summary for ZNF572 Gene

ZNF572 (Zinc Finger Protein 572) is a Protein Coding gene. Diseases associated with ZNF572 include Posterior Myocardial Infarction and Third-Degree Atrioventricular Block. An important paralog of this gene is ZNF774.

UniProtKB/Swiss-Prot Summary for ZNF572 Gene

Additional gene information for ZNF572 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF572 Gene

Genomics for ZNF572 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF572 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF572 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF572

Top Transcription factor binding sites by QIAGEN in the ZNF572 gene promoter:
  • c-Ets-1
  • C/EBPbeta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Pax-3
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ZNF572 Gene

Genomic Locations for ZNF572 Gene
chr8:124,973,295-124,979,389
(GRCh38/hg38)
Size:
6,095 bases
Orientation:
Plus strand
chr8:125,985,539-125,991,631
(GRCh37/hg19)
Size:
6,093 bases
Orientation:
Plus strand

Genomic View for ZNF572 Gene

Genes around ZNF572 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF572 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF572 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF572 Gene

Proteins for ZNF572 Gene

  • Protein details for ZNF572 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3I7-ZN572_HUMAN
    Recommended name:
    Zinc finger protein 572
    Protein Accession:
    Q7Z3I7
    Secondary Accessions:
    • A1L4E9
    • A1L4F1
    • Q8N1Q0

    Protein attributes for ZNF572 Gene

    Size:
    529 amino acids
    Molecular mass:
    61238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF572 Gene

Post-translational modifications for ZNF572 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF572 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF572 Gene

Domains & Families for ZNF572 Gene

Gene Families for ZNF572 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF572 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF572 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 572 (A1L4E9_HUMAN)
  • Zinc finger protein 572 (ZN572_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z3I7

UniProtKB/Swiss-Prot:

ZN572_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF572: view

Function for ZNF572 Gene

Molecular function for ZNF572 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF572 Gene

Gene Ontology (GO) - Molecular Function for ZNF572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF572: view

Phenotypes for ZNF572 Gene

genes like me logo Genes that share phenotypes with ZNF572: view

Animal Model Products

CRISPR Products

miRNA for ZNF572 Gene

miRTarBase miRNAs that target ZNF572

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF572

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF572 Gene

Localization for ZNF572 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF572 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF572 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF572: view

Pathways & Interactions for ZNF572 Gene

PathCards logo

SuperPathways for ZNF572 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF572: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF572 Gene

Drugs & Compounds for ZNF572 Gene

No Compound Related Data Available

Transcripts for ZNF572 Gene

mRNA/cDNA for ZNF572 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF572

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF572 Gene

No ASD Table

Relevant External Links for ZNF572 Gene

GeneLoc Exon Structure for
ZNF572

Expression for ZNF572 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF572 Gene

Protein differential expression in normal tissues from HIPED for ZNF572 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF572 Gene



Protein tissue co-expression partners for ZNF572 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF572

SOURCE GeneReport for Unigene cluster for ZNF572 Gene:

Hs.175350
genes like me logo Genes that share expression patterns with ZNF572: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF572 Gene

Orthologs for ZNF572 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF572 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF572 30 31
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF572 30 31
  • 86.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF572 30 31
  • 85.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF572 31
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF572 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF572 Gene

ENSEMBL:
Gene Tree for ZNF572 (if available)
TreeFam:
Gene Tree for ZNF572 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF572: view image

Paralogs for ZNF572 Gene

(500) SIMAP similar genes for ZNF572 Gene using alignment to 2 proteins:

  • ZN572_HUMAN
  • A1L4E9_HUMAN
genes like me logo Genes that share paralogs with ZNF572: view

Variants for ZNF572 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF572 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
VAR_035591 A colorectal cancer sample p.Cys512Phe
rs10104558 - p.Lys317Thr
rs10105106 - p.Gly380Glu
rs10107774 - p.Ser448Cys
rs7825375 - p.Val500Ile

Additional dbSNP identifiers (rs#s) for ZNF572 Gene

Variation tolerance for ZNF572 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF572 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF572

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF572 Gene

Disorders for ZNF572 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF572 Gene - From: DISEASES

Disorder Aliases PubMed IDs
posterior myocardial infarction
third-degree atrioventricular block
  • complete av block
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF572: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF572 Gene

Publications for ZNF572 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF572 Gene

Sources for ZNF572 Gene