Aliases for ZNF570 Gene

Aliases for ZNF570 Gene

  • Zinc Finger Protein 570 2 3 4 5
  • FLJ30791 2
  • ZNF570 5

External Ids for ZNF570 Gene

Previous GeneCards Identifiers for ZNF570 Gene

  • GC19P042653
  • GC19P042654
  • GC19P037959
  • GC19P034410

Summaries for ZNF570 Gene

GeneCards Summary for ZNF570 Gene

ZNF570 (Zinc Finger Protein 570) is a Protein Coding gene. Diseases associated with ZNF570 include Bardet-Biedl Syndrome 12. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF583.

UniProtKB/Swiss-Prot Summary for ZNF570 Gene

Additional gene information for ZNF570 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF570 Gene

Genomics for ZNF570 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF570 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF570 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF570

Top Transcription factor binding sites by QIAGEN in the ZNF570 gene promoter:
  • AP-1
  • FOXO4
  • GR
  • GR-alpha
  • GR-beta
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5B

Genomic Locations for ZNF570 Gene

Genomic Locations for ZNF570 Gene
chr19:37,467,465-37,488,652
(GRCh38/hg38)
Size:
21,188 bases
Orientation:
Plus strand
chr19:37,958,487-37,976,260
(GRCh37/hg19)
Size:
17,774 bases
Orientation:
Plus strand

Genomic View for ZNF570 Gene

Genes around ZNF570 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF570 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF570 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF570 Gene

Proteins for ZNF570 Gene

  • Protein details for ZNF570 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NI8-ZN570_HUMAN
    Recommended name:
    Zinc finger protein 570
    Protein Accession:
    Q96NI8
    Secondary Accessions:
    • A1L472
    • B4DMP1

    Protein attributes for ZNF570 Gene

    Size:
    536 amino acids
    Molecular mass:
    62330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF570 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF570 Gene

Post-translational modifications for ZNF570 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF570 Gene

Domains & Families for ZNF570 Gene

Gene Families for ZNF570 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF570 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF570 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52331, highly similar to Zinc finger protein 570 (B4DMP1_HUMAN)
  • Zinc finger protein 570 (ZN570_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NI8

UniProtKB/Swiss-Prot:

ZN570_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF570: view

Function for ZNF570 Gene

Molecular function for ZNF570 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF570 Gene

Gene Ontology (GO) - Molecular Function for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF570: view
genes like me logo Genes that share phenotypes with ZNF570: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF570

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF570 Gene

Localization for ZNF570 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF570 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF570 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF570: view

Pathways & Interactions for ZNF570 Gene

genes like me logo Genes that share pathways with ZNF570: view

Pathways by source for ZNF570 Gene

2 Reactome pathways for ZNF570 Gene
1 KEGG pathway for ZNF570 Gene

Interacting Proteins for ZNF570 Gene

Gene Ontology (GO) - Biological Process for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF570: view

No data available for SIGNOR curated interactions for ZNF570 Gene

Drugs & Compounds for ZNF570 Gene

No Compound Related Data Available

Transcripts for ZNF570 Gene

mRNA/cDNA for ZNF570 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF570

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF570 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF570 Gene

GeneLoc Exon Structure for
ZNF570

Expression for ZNF570 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF570 Gene

Protein differential expression in normal tissues from HIPED for ZNF570 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF570 Gene



Protein tissue co-expression partners for ZNF570 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF570

SOURCE GeneReport for Unigene cluster for ZNF570 Gene:

Hs.350875

Evidence on tissue expression from TISSUES for ZNF570 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF570: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF570 Gene

Orthologs for ZNF570 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF570 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF570 30 31
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF570 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF570 30 31
  • 92.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100359523 30
  • 80.64 (n)
Mouse
(Mus musculus)
Mammalia Zfp78 31
  • 53 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC101883198 30
  • 56.6 (n)
Species where no ortholog for ZNF570 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF570 Gene

ENSEMBL:
Gene Tree for ZNF570 (if available)
TreeFam:
Gene Tree for ZNF570 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF570: view image

Paralogs for ZNF570 Gene

(552) SIMAP similar genes for ZNF570 Gene using alignment to 7 proteins:

  • ZN570_HUMAN
  • B4DMP1_HUMAN
  • K7EMF5_HUMAN
  • K7ENX9_HUMAN
  • K7EP39_HUMAN
  • K7EP64_HUMAN
  • K7EQY8_HUMAN
genes like me logo Genes that share paralogs with ZNF570: view

Variants for ZNF570 Gene

Additional dbSNP identifiers (rs#s) for ZNF570 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF570 Gene

Variant ID Type Subtype PubMed ID
esv2675530 CNV deletion 23128226
esv2718519 CNV deletion 23290073
esv2758759 CNV loss 17122850
esv28496 CNV loss 19812545
esv3556355 CNV deletion 23714750
esv3644287 CNV loss 21293372
nsv1056753 CNV loss 25217958
nsv579466 CNV loss 21841781
nsv579467 CNV loss 21841781
nsv833819 CNV gain 17160897

Variation tolerance for ZNF570 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF570 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF570

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF570 Gene

Disorders for ZNF570 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF570 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 12
  • bbs12
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF570: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF570 Gene

Publications for ZNF570 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ZNF570 Gene

Sources for ZNF570 Gene