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Aliases for ZNF570 Gene

Aliases for ZNF570 Gene

  • Zinc Finger Protein 570 2 3 5

External Ids for ZNF570 Gene

Previous GeneCards Identifiers for ZNF570 Gene

  • GC19P042653
  • GC19P042654
  • GC19P037959
  • GC19P034410

Summaries for ZNF570 Gene

GeneCards Summary for ZNF570 Gene

ZNF570 (Zinc Finger Protein 570) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF583.

UniProtKB/Swiss-Prot for ZNF570 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF570 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF570 Gene

Genomics for ZNF570 Gene

GeneHancer (GH) Regulatory Elements for ZNF570 Gene

Promoters and enhancers for ZNF570 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I037466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 583.6 +0.8 750 4.4 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A ZNF570 ZNF569 ZNF567 ZNF345 ZNF383 ZNF527 ZNF850 ZNF571 ZNF585B HKR1
GH19I037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.9 +187.8 187835 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZFP30 ZNF527 ZNF567 ZNF383 ZNF345 ZNF571 ZNF790 HKR1 ZNF850 ZNF585A
GH19I036849 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.8 -617.3 -617282 3.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF416 ZNF207 ZNF345 ZNF790 ZNF527 ZNF567 ZNF383 ZNF585B HKR1 ZNF850 ZFP30 ZNF571
GH19I038336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.8 +869.0 868960 2.5 CLOCK MLX DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 CATSPERG HNRNPL ZNF527 ZFP30 ZNF571 ZNF573 ZNF607 ZNF793 ENSG00000269688 C19orf33
GH19I036836 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.8 -629.4 -629396 2.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF790 ZNF383 ZNF345 ZNF850 ZNF567 ZNF527 ZNF585B ZNF571 ZNF573 HKR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF570 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF570 gene promoter:

Genomic Locations for ZNF570 Gene

Genomic Locations for ZNF570 Gene
chr19:37,467,465-37,488,652
(GRCh38/hg38)
Size:
21,188 bases
Orientation:
Plus strand
chr19:37,958,487-37,976,260
(GRCh37/hg19)

Genomic View for ZNF570 Gene

Genes around ZNF570 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF570 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF570 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF570 Gene

Proteins for ZNF570 Gene

  • Protein details for ZNF570 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NI8-ZN570_HUMAN
    Recommended name:
    Zinc finger protein 570
    Protein Accession:
    Q96NI8
    Secondary Accessions:
    • A1L472
    • B4DMP1

    Protein attributes for ZNF570 Gene

    Size:
    536 amino acids
    Molecular mass:
    62330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF570 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF570 Gene

Post-translational modifications for ZNF570 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF570 Gene

Domains & Families for ZNF570 Gene

Gene Families for ZNF570 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF570 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NI8

UniProtKB/Swiss-Prot:

ZN570_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF570: view

Function for ZNF570 Gene

Molecular function for ZNF570 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF570 Gene

Gene Ontology (GO) - Molecular Function for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF570: view
genes like me logo Genes that share phenotypes with ZNF570: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF570 Gene

Localization for ZNF570 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF570 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF570 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF570: view

Pathways & Interactions for ZNF570 Gene

SuperPathways for ZNF570 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF570: view

Pathways by source for ZNF570 Gene

2 Reactome pathways for ZNF570 Gene

Interacting Proteins for ZNF570 Gene

Gene Ontology (GO) - Biological Process for ZNF570 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF570: view

No data available for SIGNOR curated interactions for ZNF570 Gene

Drugs & Compounds for ZNF570 Gene

No Compound Related Data Available

Transcripts for ZNF570 Gene

mRNA/cDNA for ZNF570 Gene

Unigene Clusters for ZNF570 Gene

Zinc finger protein 570:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF570 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF570 Gene

GeneLoc Exon Structure for
ZNF570
ECgene alternative splicing isoforms for
ZNF570

Expression for ZNF570 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF570 Gene

Protein differential expression in normal tissues from HIPED for ZNF570 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF570 Gene



Protein tissue co-expression partners for ZNF570 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF570 Gene:

ZNF570

SOURCE GeneReport for Unigene cluster for ZNF570 Gene:

Hs.350875

Evidence on tissue expression from TISSUES for ZNF570 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF570: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF570 Gene

Orthologs for ZNF570 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF570 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF570 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia ZNF570 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF570 33 34
  • 92.09 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359523 33
  • 80.64 (n)
mouse
(Mus musculus)
Mammalia Zfp78 34
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101883198 33
  • 56.6 (n)
Species where no ortholog for ZNF570 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF570 Gene

ENSEMBL:
Gene Tree for ZNF570 (if available)
TreeFam:
Gene Tree for ZNF570 (if available)

Paralogs for ZNF570 Gene

(552) SIMAP similar genes for ZNF570 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF570: view

Variants for ZNF570 Gene

Sequence variations from dbSNP and Humsavar for ZNF570 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000164546 -- 37,484,128(+) G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000538705 -- 37,488,488(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000687284 -- 37,481,676(+) A/T intron_variant
rs1000801628 -- 37,465,500(+) A/G upstream_transcript_variant
rs1001123030 -- 37,485,926(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF570 Gene

Variant ID Type Subtype PubMed ID
nsv833819 CNV gain 17160897
nsv579467 CNV loss 21841781
nsv579466 CNV loss 21841781
nsv1056753 CNV loss 25217958
esv3644287 CNV loss 21293372
esv3556355 CNV deletion 23714750
esv28496 CNV loss 19812545
esv2758759 CNV loss 17122850
esv2718519 CNV deletion 23290073
esv2675530 CNV deletion 23128226

Variation tolerance for ZNF570 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF570 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF570

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF570 Gene

Disorders for ZNF570 Gene

Additional Disease Information for ZNF570

No disorders were found for ZNF570 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF570 Gene

Publications for ZNF570 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ZNF570 Gene

Sources for ZNF570 Gene

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