Aliases for ZNF57 Gene

Aliases for ZNF57 Gene

  • Zinc Finger Protein 57 2 3 4 5
  • Zinc Finger Protein 424 2 3 4
  • ZNF424 3 4

External Ids for ZNF57 Gene

Previous HGNC Symbols for ZNF57 Gene

  • ZNF424

Previous GeneCards Identifiers for ZNF57 Gene

  • GC19U990105
  • GC19P002852
  • GC19P002671

Summaries for ZNF57 Gene

GeneCards Summary for ZNF57 Gene

ZNF57 (Zinc Finger Protein 57) is a Protein Coding gene. Diseases associated with ZNF57 include Breast Medullary Carcinoma and Transient Neonatal Diabetes Mellitus. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot Summary for ZNF57 Gene

Additional gene information for ZNF57 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF57 Gene

Genomics for ZNF57 Gene

GeneHancer (GH) Regulatory Elements for ZNF57 Gene

Promoters and enhancers for ZNF57 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002899 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.3 +0.8 779 3.5 HNRNPK NRF1 USF1 POLR2G SP1 NCOR1 PHF8 ZBTB5 ZIC2 ZBTB10 ZNF57 ENSG00000253392 LOC101928631
GH19J002840 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.1 -59.1 -59097 3.2 EP300 CTCF NRF1 POLR2G SP1 JUND PHF8 FOS ZNF639 ZIC2 ZNF555 ZNF77 SF3A2 CACTIN GNA11 ZNF556 ZNF57 ENSG00000253392 SCAMP4 CSNK1G2
GH19J002817 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -81.6 -81597 4.2 ZNF217 EP300 CTCF TCF12 MYC NRF1 POLR2G USF1 SP1 SIX5 ZNF554 piR-50437-320 ZNF77 CACTIN CACTIN-AS1 SF3A2 THOP1 APBA3 SPPL2B ZNF556
GH19J002976 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +76.6 76565 2.5 EP300 CTCF SIN3A POLR2G USF1 SP1 NCOR1 FOS ZIC2 ZBTB10 TLE6 GNA11 ZNF77 S1PR4 NCLN ENSG00000253392 ZNF57 SLC39A3 RF00017-2740
GH19J002949 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 11.1 +49.3 49304 2.4 ZBTB40 ZNF217 CTCF NRF1 POLR2G SP1 NCOR1 PHF8 PHB2 ZNF639 ENSG00000279452 lnc-ZNF77-2 ENSG00000253392 ZNF57 TLE6 NCLN ENSG00000267283 SF3A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF57 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF57

Genomic Locations for ZNF57 Gene

Genomic Locations for ZNF57 Gene
chr19:2,900,898-2,918,646
(GRCh38/hg38)
Size:
17,749 bases
Orientation:
Plus strand
chr19:2,900,896-2,918,474
(GRCh37/hg19)
Size:
17,579 bases
Orientation:
Plus strand

Genomic View for ZNF57 Gene

Genes around ZNF57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF57 Gene

Proteins for ZNF57 Gene

  • Protein details for ZNF57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68EA5-ZNF57_HUMAN
    Recommended name:
    Zinc finger protein 57
    Protein Accession:
    Q68EA5
    Secondary Accessions:
    • Q8N6R9

    Protein attributes for ZNF57 Gene

    Size:
    555 amino acids
    Molecular mass:
    64428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF57 Gene

Post-translational modifications for ZNF57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF57 Gene

No data available for DME Specific Peptides for ZNF57 Gene

Domains & Families for ZNF57 Gene

Gene Families for ZNF57 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF57 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF57 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 424 (ZNF57_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68EA5

UniProtKB/Swiss-Prot:

ZNF57_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF57: view

Function for ZNF57 Gene

Molecular function for ZNF57 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 57 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF57 Gene

Gene Ontology (GO) - Molecular Function for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF57: view
genes like me logo Genes that share phenotypes with ZNF57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF57

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF57 Gene

Localization for ZNF57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF57 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF57: view

Pathways & Interactions for ZNF57 Gene

PathCards logo

SuperPathways for ZNF57 Gene

genes like me logo Genes that share pathways with ZNF57: view

Pathways by source for ZNF57 Gene

1 KEGG pathway for ZNF57 Gene

Gene Ontology (GO) - Biological Process for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF57: view

No data available for SIGNOR curated interactions for ZNF57 Gene

Drugs & Compounds for ZNF57 Gene

No Compound Related Data Available

Transcripts for ZNF57 Gene

mRNA/cDNA for ZNF57 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF57

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF57 Gene

No ASD Table

Relevant External Links for ZNF57 Gene

GeneLoc Exon Structure for
ZNF57

Expression for ZNF57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF57 Gene

Protein differential expression in normal tissues from HIPED for ZNF57 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF57 Gene



Protein tissue co-expression partners for ZNF57 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF57

SOURCE GeneReport for Unigene cluster for ZNF57 Gene:

Hs.591378
genes like me logo Genes that share expression patterns with ZNF57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF57 Gene

Orthologs for ZNF57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF57 31 30
  • 98.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 40 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp81 31
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CT573234.2 31
  • 35 (a)
ManyToMany
CR388132.2 31
  • 35 (a)
ManyToMany
Species where no ortholog for ZNF57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF57 Gene

ENSEMBL:
Gene Tree for ZNF57 (if available)
TreeFam:
Gene Tree for ZNF57 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF57: view image

Paralogs for ZNF57 Gene

(481) SIMAP similar genes for ZNF57 Gene using alignment to 4 proteins:

  • ZNF57_HUMAN
  • E5RHE3_HUMAN
  • G3V131_HUMAN
  • K7ERB8_HUMAN

Pseudogenes.org Pseudogenes for ZNF57 Gene

genes like me logo Genes that share paralogs with ZNF57: view

Variants for ZNF57 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF57 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2288957 - p.Arg230Trp
rs2288958 - p.Thr223Asn
rs55682587 - p.Thr357Met

Additional dbSNP identifiers (rs#s) for ZNF57 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF57 Gene

Variant ID Type Subtype PubMed ID
dgv1689n106 CNV deletion 24896259
dgv215e215 CNV deletion 23714750
esv1000566 CNV deletion 20482838
esv1105151 CNV deletion 17803354
esv22112 CNV gain 19812545
esv2555501 CNV deletion 19546169
esv2658906 CNV deletion 23128226
esv2674415 CNV deletion 23128226
esv2717919 CNV deletion 23290073
esv2762020 CNV loss 21179565
esv3643441 CNV loss 21293372
esv3643442 CNV loss 21293372
esv3643443 CNV loss 21293372
esv3643444 CNV loss 21293372
nsv1063039 CNV loss 25217958
nsv1065985 CNV loss 25217958
nsv511619 CNV loss 21212237
nsv512558 CNV loss 21212237
nsv578416 CNV gain 21841781
nsv578417 CNV gain+loss 21841781
nsv578418 CNV loss 21841781
nsv578419 CNV loss 21841781
nsv821398 CNV deletion 20802225
nsv956564 CNV deletion 24416366
nsv960772 CNV duplication 23825009

Variation tolerance for ZNF57 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF57

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF57 Gene

Disorders for ZNF57 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF57 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast medullary carcinoma
  • medullary breast carcinoma with lymphoid stroma
transient neonatal diabetes mellitus
  • tndm1
- elite association - COSMIC cancer census association via MalaCards
Search ZNF57 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF57

genes like me logo Genes that share disorders with ZNF57: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF57 Gene

Publications for ZNF57 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  4. ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells. (PMID: 29974829) Liu W … Wu X (Current molecular medicine 2018) 3 54
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 54

Products for ZNF57 Gene

Sources for ZNF57 Gene