Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF57 Gene

Aliases for ZNF57 Gene

  • Zinc Finger Protein 57 2 3 5
  • Zinc Finger Protein 424 2 3 4
  • ZNF424 3 4

External Ids for ZNF57 Gene

Previous HGNC Symbols for ZNF57 Gene

  • ZNF424

Previous GeneCards Identifiers for ZNF57 Gene

  • GC19U990105
  • GC19P002852
  • GC19P002671

Summaries for ZNF57 Gene

GeneCards Summary for ZNF57 Gene

ZNF57 (Zinc Finger Protein 57) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF555.

UniProtKB/Swiss-Prot for ZNF57 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF57 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF57 Gene

Genomics for ZNF57 Gene

GeneHancer (GH) Regulatory Elements for ZNF57 Gene

Promoters and enhancers for ZNF57 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002899 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.4 +0.8 779 3.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF57 ZNF77 CACTIN ZNF555 ZNF554 LSM7 LOC101928631 GC19M002916
GH19I002819 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.8 -80.9 -80896 1.6 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF766 CBX5 E2F8 ZNF207 ZNF143 ZNF554 GC19P002822 ZNF77 CACTIN-AS1 THOP1 CACTIN SF3A2 LOC100288123 SPPL2B ZNF556
GH19I002976 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 +76.8 76770 2.1 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 ZNF207 TLE6 GNA11 ZNF77 S1PR4 NCLN LOC101928631 ZNF57 SLC39A3 GC19P003016
GH19I002968 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.3 +71.0 71013 7 PKNOX1 FEZF1 TCF12 ZNF121 ZNF766 GLIS2 GATA2 E2F8 ATF7 ZNF263 GC19M002962 NCLN TLE6 TLE2 AES ZNF77 GNA11 LOC101928631 ZNF57 S1PR4
GH19I002949 Enhancer 1.3 Ensembl ENCODE 11.1 +49.4 49396 2.3 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 NBN ENSG00000279452 GC19M002947 SF3A2 CACTIN-AS1 APBA3 CACTIN DOT1L LOC101928631 ZNF57 TLE6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF57 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF57 Gene

Genomic Locations for ZNF57 Gene
17,749 bases
Plus strand

Genomic View for ZNF57 Gene

Genes around ZNF57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF57 Gene

Proteins for ZNF57 Gene

  • Protein details for ZNF57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 57
    Protein Accession:
    Secondary Accessions:
    • Q8N6R9

    Protein attributes for ZNF57 Gene

    555 amino acids
    Molecular mass:
    64428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF57 Gene

Post-translational modifications for ZNF57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF57 Gene

No data available for DME Specific Peptides for ZNF57 Gene

Domains & Families for ZNF57 Gene

Gene Families for ZNF57 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF57 Gene

Suggested Antigen Peptide Sequences for ZNF57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF57: view

Function for ZNF57 Gene

Molecular function for ZNF57 Gene

GENATLAS Biochemistry:
zinc finger protein 57 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF57: view
genes like me logo Genes that share phenotypes with ZNF57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZNF57

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF57 Gene

Localization for ZNF57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF57 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF57 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF57: view

Pathways & Interactions for ZNF57 Gene

SuperPathways for ZNF57 Gene

No Data Available

Interacting Proteins for ZNF57 Gene

Gene Ontology (GO) - Biological Process for ZNF57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF57: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF57 Gene

Drugs & Compounds for ZNF57 Gene

No Compound Related Data Available

Transcripts for ZNF57 Gene

mRNA/cDNA for ZNF57 Gene

Unigene Clusters for ZNF57 Gene

Zinc finger protein 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZNF57

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF57 Gene

No ASD Table

Relevant External Links for ZNF57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF57 Gene

Protein differential expression in normal tissues from HIPED for ZNF57 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF57 Gene

Protein tissue co-expression partners for ZNF57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF57 Gene:


SOURCE GeneReport for Unigene cluster for ZNF57 Gene:

genes like me logo Genes that share expression patterns with ZNF57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF57 Gene

Orthologs for ZNF57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF57 33 34
  • 98.56 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 41 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
(Mus musculus)
Mammalia Zfp81 34
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
(Danio rerio)
Actinopterygii CR388132.2 34
  • 35 (a)
CT573234.2 34
  • 35 (a)
Species where no ortholog for ZNF57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF57 Gene

Gene Tree for ZNF57 (if available)
Gene Tree for ZNF57 (if available)

Paralogs for ZNF57 Gene

(481) SIMAP similar genes for ZNF57 Gene using alignment to 4 proteins: Pseudogenes for ZNF57 Gene

genes like me logo Genes that share paralogs with ZNF57: view

Variants for ZNF57 Gene

Sequence variations from dbSNP and Humsavar for ZNF57 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000045535 -- 2,901,389(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000073561 -- 2,913,829(+) C/T intron_variant
rs1000423627 -- 2,914,074(+) A/C intron_variant
rs1000482647 -- 2,912,401(+) G/A/C intron_variant
rs1000495396 -- 2,908,695(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF57 Gene

Variant ID Type Subtype PubMed ID
dgv1689n106 CNV deletion 24896259
dgv215e215 CNV deletion 23714750
esv1000566 CNV deletion 20482838
esv1105151 CNV deletion 17803354
esv22112 CNV gain 19812545
esv2555501 CNV deletion 19546169
esv2658906 CNV deletion 23128226
esv2674415 CNV deletion 23128226
esv2717919 CNV deletion 23290073
esv2762020 CNV loss 21179565
esv3643441 CNV loss 21293372
esv3643442 CNV loss 21293372
esv3643443 CNV loss 21293372
esv3643444 CNV loss 21293372
nsv1063039 CNV loss 25217958
nsv1065985 CNV loss 25217958
nsv511619 CNV loss 21212237
nsv512558 CNV loss 21212237
nsv578416 CNV gain 21841781
nsv578417 CNV gain+loss 21841781
nsv578418 CNV loss 21841781
nsv578419 CNV loss 21841781
nsv821398 CNV deletion 20802225
nsv956564 CNV deletion 24416366
nsv960772 CNV duplication 23825009

Variation tolerance for ZNF57 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF57 Gene

Disorders for ZNF57 Gene

Additional Disease Information for ZNF57

No disorders were found for ZNF57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF57 Gene

Publications for ZNF57 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 58
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  4. ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway. (PMID: 20356463) Wang Y … Wu X (BMB reports 2010) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF57 Gene

  • Addgene plasmids for ZNF57

Sources for ZNF57 Gene

Loading form....