Aliases for ZNF569 Gene

Aliases for ZNF569 Gene

  • Zinc Finger Protein 569 2 3 4 5
  • DNA-Binding Protein 3
  • Zfp74 3
  • ZAP1 3
  • ZNF 3

External Ids for ZNF569 Gene

Previous GeneCards Identifiers for ZNF569 Gene

  • GC19M042336
  • GC19M042593
  • GC19M037902
  • GC19M034352

Summaries for ZNF569 Gene

GeneCards Summary for ZNF569 Gene

ZNF569 (Zinc Finger Protein 569) is a Protein Coding gene. Diseases associated with ZNF569 include Amyotrophic Lateral Sclerosis 3 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF84.

UniProtKB/Swiss-Prot Summary for ZNF569 Gene

Additional gene information for ZNF569 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF569 Gene

Genomics for ZNF569 Gene

GeneHancer (GH) Regulatory Elements for ZNF569 Gene

Promoters and enhancers for ZNF569 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF569 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF569

Top Transcription factor binding sites by QIAGEN in the ZNF569 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXO4
  • GR
  • GR-alpha
  • GR-beta
  • STAT3
  • STAT5B

Genomic Locations for ZNF569 Gene

Genomic Locations for ZNF569 Gene
chr19:37,410,876-37,469,275
(GRCh38/hg38)
Size:
58,400 bases
Orientation:
Minus strand
chr19:37,902,057-37,960,177
(GRCh37/hg19)
Size:
58,121 bases
Orientation:
Minus strand

Genomic View for ZNF569 Gene

Genes around ZNF569 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF569 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF569 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF569 Gene

Proteins for ZNF569 Gene

  • Protein details for ZNF569 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MCW4-ZN569_HUMAN
    Recommended name:
    Zinc finger protein 569
    Protein Accession:
    Q5MCW4
    Secondary Accessions:
    • A8K1S2
    • Q15925
    • Q17RR6
    • Q96MQ2

    Protein attributes for ZNF569 Gene

    Size:
    686 amino acids
    Molecular mass:
    79583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK056615; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF569 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF569 Gene

Post-translational modifications for ZNF569 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF569 Gene

Domains & Families for ZNF569 Gene

Gene Families for ZNF569 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF569 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF569 Gene

GenScript: Design optimal peptide antigens:
  • ZNF569 protein (Q17RR6_HUMAN)
  • Zinc finger protein 569 (ZN569_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5MCW4

UniProtKB/Swiss-Prot:

ZN569_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF569: view

Function for ZNF569 Gene

Molecular function for ZNF569 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF569 Gene

Gene Ontology (GO) - Molecular Function for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF569: view
genes like me logo Genes that share phenotypes with ZNF569: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZNF569

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF569

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF569 Gene

Localization for ZNF569 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF569 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF569 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF569: view

Pathways & Interactions for ZNF569 Gene

genes like me logo Genes that share pathways with ZNF569: view

Pathways by source for ZNF569 Gene

2 Reactome pathways for ZNF569 Gene
1 KEGG pathway for ZNF569 Gene

Gene Ontology (GO) - Biological Process for ZNF569 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF569: view

No data available for SIGNOR curated interactions for ZNF569 Gene

Drugs & Compounds for ZNF569 Gene

No Compound Related Data Available

Transcripts for ZNF569 Gene

mRNA/cDNA for ZNF569 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF569

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF569 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2:
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: -
SP10: - - - - - - - - - - - - - -
SP11:

Relevant External Links for ZNF569 Gene

GeneLoc Exon Structure for
ZNF569

Expression for ZNF569 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF569 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF569

SOURCE GeneReport for Unigene cluster for ZNF569 Gene:

Hs.511848

Evidence on tissue expression from TISSUES for ZNF569 Gene

  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF569: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF569 Gene

Orthologs for ZNF569 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF569 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF569 31 30
  • 99.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF569 31 30
  • 91.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp74 30
  • 81.02 (n)
mouse
(Mus musculus)
Mammalia Zfp74 17 31 30
  • 80.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733241 30
  • 60.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009566 30
  • 51.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta crol 30
  • 45.77 (n)
Species where no ortholog for ZNF569 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF569 Gene

ENSEMBL:
Gene Tree for ZNF569 (if available)
TreeFam:
Gene Tree for ZNF569 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF569: view image

Paralogs for ZNF569 Gene

(559) SIMAP similar genes for ZNF569 Gene using alignment to 6 proteins:

  • ZN569_HUMAN
  • K7EJ12_HUMAN
  • K7EKE0_HUMAN
  • K7ELU1_HUMAN
  • K7ENQ2_HUMAN
  • Q17RR6_HUMAN

Pseudogenes.org Pseudogenes for ZNF569 Gene

genes like me logo Genes that share paralogs with ZNF569: view

Variants for ZNF569 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF569 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1349967796 A breast cancer sample p.Glu87Gly
VAR_035589 A breast cancer sample p.Gln29Glu

Additional dbSNP identifiers (rs#s) for ZNF569 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF569 Gene

Variant ID Type Subtype PubMed ID
esv2758759 CNV loss 17122850
nsv579465 CNV loss 21841781
nsv833819 CNV gain 17160897

Variation tolerance for ZNF569 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF569 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF569

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF569 Gene

Disorders for ZNF569 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF569 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF569

genes like me logo Genes that share disorders with ZNF569: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF569 Gene

Publications for ZNF569 Gene

  1. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 16793018) Huang X … Wu X (Biochemical and biophysical research communications 2006) 2 3 4 23 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 3 4 54
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for ZNF569 Gene

Sources for ZNF569 Gene