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Aliases for ZNF568 Gene

Aliases for ZNF568 Gene

  • Zinc Finger Protein 568 2 3 3 5
  • ZFP568 3

External Ids for ZNF568 Gene

Previous GeneCards Identifiers for ZNF568 Gene

  • GC19P042034
  • GC19P042100
  • GC19P037407
  • GC19P033876

Summaries for ZNF568 Gene

GeneCards Summary for ZNF568 Gene

ZNF568 (Zinc Finger Protein 568) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot for ZNF568 Gene

  • Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

Additional gene information for ZNF568 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF568 Gene

Genomics for ZNF568 Gene

GeneHancer (GH) Regulatory Elements for ZNF568 Gene

Promoters and enhancers for ZNF568 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036915 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 749 +0.2 166 2.2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 ZNF548 SP3 REST ZNF568 ZNF829 GC19M039148 ZNF567 ZNF345 ZNF527 ZNF383 ZFP30 ZNF571 ZNF850
GH19J036972 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 681.3 +57.1 57069 2 CTCF SIN3A RAD21 YY1 ETS1 POLR2A SCRT2 ZNF143 RCOR1 ZNF444 ZNF568 ZNF383 ZNF527 LINC01535 ZNF585B ZNF345 ZNF850 ZNF567 ZNF573 ZNF829
GH19J036916 Enhancer 0.5 ENCODE 688.7 -1.1 -1148 0.1 ZSCAN26 ZNF473 ZNF621 ZBTB11 ZNF280C ZNF248 ZNF568 ZNF829 ZNF527 ZFP30 ZNF571 ZNF790 ZNF585B ZNF566 ZNF260 ZNF529
GH19J037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 104.4 +678.4 678372 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZNF345 ZNF383 HKR1 ZFP30 ZNF850 ZNF607
GH19J037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 102.7 +454.7 454711 1.9 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610 ZNF527 ZNF567 ZNF345 ZNF383 ZNF850 HKR1 ZNF571 ZFP30 ZNF793 ZNF790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF568 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF568 gene promoter:
  • HEN1
  • STAT3
  • c-Ets-1
  • AREB6
  • STAT1
  • NRF-2
  • Pax-2a
  • Pax-2
  • Arnt
  • AhR

Genomic Locations for ZNF568 Gene

Genomic Locations for ZNF568 Gene
chr19:36,916,329-36,998,700
(GRCh38/hg38)
Size:
82,372 bases
Orientation:
Plus strand
chr19:37,407,231-37,489,602
(GRCh37/hg19)
Size:
82,372 bases
Orientation:
Plus strand

Genomic View for ZNF568 Gene

Genes around ZNF568 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF568 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF568 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF568 Gene

Proteins for ZNF568 Gene

  • Protein details for ZNF568 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCX4-ZN568_HUMAN
    Recommended name:
    Zinc finger protein 568
    Protein Accession:
    Q3ZCX4
    Secondary Accessions:
    • B4DS92
    • E7ER33
    • Q6N060
    • Q8NA64

    Protein attributes for ZNF568 Gene

    Size:
    644 amino acids
    Molecular mass:
    74369 Da
    Quaternary structure:
    • Interacts with TRIM28.
    SequenceCaution:
    • Sequence=AAH31218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAE45810.1; Type=Frameshift; Positions=436; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF568 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF568 Gene

Post-translational modifications for ZNF568 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF568 Gene

Domains & Families for ZNF568 Gene

Gene Families for ZNF568 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF568 Gene

Suggested Antigen Peptide Sequences for ZNF568 Gene

Graphical View of Domain Structure for InterPro Entry

Q3ZCX4

UniProtKB/Swiss-Prot:

ZN568_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF568: view

Function for ZNF568 Gene

Molecular function for ZNF568 Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

Phenotypes From GWAS Catalog for ZNF568 Gene

Gene Ontology (GO) - Molecular Function for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with ZNF568: view
genes like me logo Genes that share phenotypes with ZNF568: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF568

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF568 Gene

Localization for ZNF568 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF568 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF568 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF568: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF568 Gene

Pathways & Interactions for ZNF568 Gene

SuperPathways for ZNF568 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF568: view

Pathways by source for ZNF568 Gene

2 Reactome pathways for ZNF568 Gene

Gene Ontology (GO) - Biological Process for ZNF568 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001701 in utero embryonic development ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZNF568: view

No data available for SIGNOR curated interactions for ZNF568 Gene

Drugs & Compounds for ZNF568 Gene

No Compound Related Data Available

Transcripts for ZNF568 Gene

mRNA/cDNA for ZNF568 Gene

(14) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF568 Gene

Zinc finger protein 568:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF568

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF568 Gene

No ASD Table

Relevant External Links for ZNF568 Gene

GeneLoc Exon Structure for
ZNF568
ECgene alternative splicing isoforms for
ZNF568

Expression for ZNF568 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF568 Gene

Protein differential expression in normal tissues from HIPED for ZNF568 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF568 Gene



Protein tissue co-expression partners for ZNF568 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF568 Gene:

ZNF568

SOURCE GeneReport for Unigene cluster for ZNF568 Gene:

Hs.404220

Evidence on tissue expression from TISSUES for ZNF568 Gene

  • Nervous system(4.5)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF568: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF568 Gene

Orthologs for ZNF568 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF568 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF568 34 33
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF568 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF568 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp569 33
  • 82.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
Species where no ortholog for ZNF568 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF568 Gene

ENSEMBL:
Gene Tree for ZNF568 (if available)
TreeFam:
Gene Tree for ZNF568 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF568: view image

Paralogs for ZNF568 Gene

(568) SIMAP similar genes for ZNF568 Gene using alignment to 10 proteins:

  • ZN568_HUMAN
  • A2VDJ6_HUMAN
  • C9JLX5_HUMAN
  • C9JXQ5_HUMAN
  • C9JZ58_HUMAN
  • C9K0F2_HUMAN
  • K7EKY2_HUMAN
  • K7EL97_HUMAN
  • K7ELK8_HUMAN
  • Q96AZ9_HUMAN
genes like me logo Genes that share paralogs with ZNF568: view

Variants for ZNF568 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF568 Gene

ZN568_HUMAN-Q3ZCX4
Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.

Sequence variations from dbSNP and Humsavar for ZNF568 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000004322 -- 36,959,801(+) G/A/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000020396 -- 36,968,635(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000056648 -- 36,960,314(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000148084 -- 36,959,426(+) G/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000155235 -- 36,961,137(+) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF568 Gene

Variant ID Type Subtype PubMed ID
esv2370712 CNV deletion 18987734
esv2677892 CNV deletion 23128226
esv2718512 CNV deletion 23290073
esv2718513 CNV deletion 23290073
esv2718514 CNV deletion 23290073
esv3222174 CNV deletion 24192839
esv3556348 CNV deletion 23714750
esv3556350 CNV deletion 23714750
esv3556351 CNV deletion 23714750
esv3644274 CNV loss 21293372
esv3893201 CNV gain 25118596
esv990224 CNV deletion 20482838
nsv1064851 CNV loss 25217958
nsv1070675 CNV deletion 25765185
nsv1138701 CNV deletion 24896259
nsv1149441 CNV deletion 26484159
nsv138138 CNV deletion 16902084
nsv138492 CNV deletion 16902084
nsv458569 CNV loss 19166990
nsv509740 CNV insertion 20534489
nsv521605 CNV loss 19592680
nsv523848 CNV loss 19592680
nsv579461 CNV gain 21841781
nsv579462 CNV loss 21841781
nsv579463 CNV loss 21841781
nsv833818 CNV gain 17160897
nsv956598 CNV deletion 24416366

Variation tolerance for ZNF568 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF568 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF568

Disorders for ZNF568 Gene

Additional Disease Information for ZNF568

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF568 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF568 Gene

Publications for ZNF568 Gene

  1. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. (PMID: 23071813) Chien HC … Shen CK (PloS one 2012) 3 4 58
  2. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso GM … Brousseau ME (Journal of lipid research 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M … Superti-Furga G (Nature methods 2013) 3 58
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 58

Products for ZNF568 Gene

Sources for ZNF568 Gene

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