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Aliases for ZNF566 Gene

Aliases for ZNF566 Gene

  • Zinc Finger Protein 566 2 3 5

External Ids for ZNF566 Gene

Previous GeneCards Identifiers for ZNF566 Gene

  • GC19M041629
  • GC19M041631
  • GC19M036936
  • GC19M033404
  • GC19M036674
  • GC19M036706
  • GC19M036890
  • GC19M036907
  • GC19M037445
  • GC19M037785
  • GC19M038083

Summaries for ZNF566 Gene

GeneCards Summary for ZNF566 Gene

ZNF566 (Zinc Finger Protein 566) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF383.

UniProtKB/Swiss-Prot for ZNF566 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF566 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF566 Gene

Genomics for ZNF566 Gene

GeneHancer (GH) Regulatory Elements for ZNF566 Gene

Promoters and enhancers for ZNF566 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I036488 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 612.1 +0.6 572 2.5 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF566 GC19P036701 LOC728752 ZNF527 ZNF383 ZNF345 ZNF850 ZNF567 TMEM147-AS1 ZNF790
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 144.4 -881.1 -881138 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
GH19I035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 102.7 +585.8 585844 13 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZFP41 NFKBID TYROBP HCST ENSG00000280194 ZNF567 ZNF566 ZNF790 ZNF529 TMEM147-AS1 ZNF260
GH19I036915 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 118.1 -426.6 -426593 2.2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 SP3 ZNF568 ZNF829 GC19M038851 ZNF527 ZNF567 ZNF345 ZNF383 ZFP30 ZNF571 ZNF850
GH19I037466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 95.9 -978.3 -978313 4.4 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A ZNF570 ZNF569 ZNF567 ZNF345 ZNF383 ZNF527 ZNF850 ZNF571 ZNF585B HKR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF566 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF566 gene promoter:

Genomic Locations for ZNF566 Gene

Genomic Locations for ZNF566 Gene
53,869 bases
Minus strand

Genomic View for ZNF566 Gene

Genes around ZNF566 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF566 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF566 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF566 Gene

Proteins for ZNF566 Gene

  • Protein details for ZNF566 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 566
    Protein Accession:
    Secondary Accessions:
    • B7ZL95
    • Q2M3J1

    Protein attributes for ZNF566 Gene

    418 amino acids
    Molecular mass:
    49219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF566 Gene


neXtProt entry for ZNF566 Gene

Post-translational modifications for ZNF566 Gene

  • Ubiquitination at isoforms=262
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF566 Gene

Domains & Families for ZNF566 Gene

Gene Families for ZNF566 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF566 Gene

Suggested Antigen Peptide Sequences for ZNF566 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF566: view

Function for ZNF566 Gene

Molecular function for ZNF566 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF566 Gene

Gene Ontology (GO) - Molecular Function for ZNF566 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF566: view
genes like me logo Genes that share phenotypes with ZNF566: view

Animal Model Products

CRISPR Products

miRNA for ZNF566 Gene

miRTarBase miRNAs that target ZNF566

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF566 Gene

Localization for ZNF566 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF566 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF566 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF566 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF566: view

Pathways & Interactions for ZNF566 Gene

SuperPathways for ZNF566 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF566: view

Pathways by source for ZNF566 Gene

2 Reactome pathways for ZNF566 Gene

Gene Ontology (GO) - Biological Process for ZNF566 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF566: view

No data available for SIGNOR curated interactions for ZNF566 Gene

Drugs & Compounds for ZNF566 Gene

No Compound Related Data Available

Transcripts for ZNF566 Gene

Unigene Clusters for ZNF566 Gene

Zinc finger protein 566:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF566 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9: -

Relevant External Links for ZNF566 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF566 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF566 Gene

Protein differential expression in normal tissues from HIPED for ZNF566 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF566 Gene

Protein tissue co-expression partners for ZNF566 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF566 Gene:


SOURCE GeneReport for Unigene cluster for ZNF566 Gene:


Evidence on tissue expression from TISSUES for ZNF566 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF566: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF566 Gene

Orthologs for ZNF566 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF566 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF566 33 34
  • 99.2 (n)
(Bos Taurus)
Mammalia ZNF566 33 34
  • 91.31 (n)
(Canis familiaris)
Mammalia ZNF566 34
  • 91 (a)
(Mus musculus)
Mammalia Zfp566 33 16 34
  • 81.69 (n)
(Rattus norvegicus)
Mammalia Zfp566 33
  • 80.57 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 34
  • 12 (a)
Species where no ortholog for ZNF566 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF566 Gene

Gene Tree for ZNF566 (if available)
Gene Tree for ZNF566 (if available)

Paralogs for ZNF566 Gene

(547) SIMAP similar genes for ZNF566 Gene using alignment to 5 proteins: Pseudogenes for ZNF566 Gene

genes like me logo Genes that share paralogs with ZNF566: view

Variants for ZNF566 Gene

Sequence variations from dbSNP and Humsavar for ZNF566 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000054786 -- 36,469,656(-) G/A intron_variant
rs1000104729 -- 36,459,499(-) C/T intron_variant
rs1000282859 -- 36,453,118(-) AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA intron_variant
rs1000461785 -- 36,449,706(-) A/G coding_sequence_variant, synonymous_variant
rs1000612846 -- 36,477,778(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF566 Gene

Variant ID Type Subtype PubMed ID
esv2675393 CNV deletion 23128226
esv3644257 CNV gain 21293372
esv3644259 CNV loss 21293372
esv3644260 CNV loss 21293372
esv3644261 CNV loss 21293372
esv3644262 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv1066026 CNV gain 25217958
nsv1067101 CNV gain 25217958
nsv1067364 CNV gain 25217958
nsv833816 CNV gain 17160897
nsv833817 CNV loss 17160897

Variation tolerance for ZNF566 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF566 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF566 Gene

Disorders for ZNF566 Gene

Additional Disease Information for ZNF566

No disorders were found for ZNF566 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF566 Gene

Publications for ZNF566 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF566 Gene

Sources for ZNF566 Gene

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