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Aliases for ZNF565 Gene

Aliases for ZNF565 Gene

  • Zinc Finger Protein 565 2 3 3 5

External Ids for ZNF565 Gene

Previous GeneCards Identifiers for ZNF565 Gene

  • GC19M041366
  • GC19M041360
  • GC19M036673
  • GC19M033177
  • GC19M036371
  • GC19M036703
  • GC19M036889
  • GC19M036906
  • GC19M037444
  • GC19M037784
  • GC19M038082
  • GC19M038370

Summaries for ZNF565 Gene

GeneCards Summary for ZNF565 Gene

ZNF565 (Zinc Finger Protein 565) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZFP14.

UniProtKB/Swiss-Prot for ZNF565 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF565 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF565 Gene

Genomics for ZNF565 Gene

GeneHancer (GH) Regulatory Elements for ZNF565 Gene

Promoters and enhancers for ZNF565 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036213 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 686.7 +30.9 30948 3.3 MLX YBX1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZNF146 ZNF565 ZNF345 ZNF567 TMEM147-AS1 ZNF850 HAUS5 ZNF790 ZNF790-AS1 PROSER3
GH19J036245 Promoter/Enhancer 1.1 Ensembl ENCODE 650.7 +0.6 613 0.9 CTCF CLOCK MAX SIN3A MNT ETS1 POLR2A ZNF143 ZNF600 SETDB1 ZNF565 LINC00665 LOC100134317 GC19M039159
GH19J036194 Promoter 0.5 EPDnew 650.2 +51.4 51430 0.1 ZNF565 LINC00665 ENSG00000200179 GC19M038673 GC19M039119
GH19J035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.4 +342.2 342199 13 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZFP41 NFKBID TYROBP HCST ENSG00000280194 ZNF567 TMEM147-AS1 ZNF790 ZNF566 ZNF529 ZNF260
GH19J035246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.3 +997.6 997632 3.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 LSR HAUS5 ZNF599 TMEM147-AS1 KMT2B RBM42 ZNF792 ZNF30 PROSER3 ZNF302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF565 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF565 gene promoter:
  • HNF-4alpha1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ZNF565 Gene

Genomic Locations for ZNF565 Gene
chr19:36,182,060-36,246,257
(GRCh38/hg38)
Size:
64,198 bases
Orientation:
Minus strand
chr19:36,673,187-36,737,159
(GRCh37/hg19)
Size:
63,973 bases
Orientation:
Minus strand

Genomic View for ZNF565 Gene

Genes around ZNF565 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF565 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF565 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF565 Gene

Proteins for ZNF565 Gene

  • Protein details for ZNF565 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9K5-ZN565_HUMAN
    Recommended name:
    Zinc finger protein 565
    Protein Accession:
    Q8N9K5
    Secondary Accessions:
    • B3KQ35
    • Q6NUS2

    Protein attributes for ZNF565 Gene

    Size:
    539 amino acids
    Molecular mass:
    62445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF565 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF565 Gene

Post-translational modifications for ZNF565 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF565 Gene

Domains & Families for ZNF565 Gene

Gene Families for ZNF565 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF565 Gene

Suggested Antigen Peptide Sequences for ZNF565 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9K5

UniProtKB/Swiss-Prot:

ZN565_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF565: view

Function for ZNF565 Gene

Molecular function for ZNF565 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF565 Gene

Gene Ontology (GO) - Molecular Function for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF565: view
genes like me logo Genes that share phenotypes with ZNF565: view

Animal Models for ZNF565 Gene

MGI Knock Outs for ZNF565:
  • Zfp84 Zfp84<tm1b(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF565 Gene

Localization for ZNF565 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF565 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF565 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF565: view

Pathways & Interactions for ZNF565 Gene

SuperPathways for ZNF565 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF565: view

Pathways by source for ZNF565 Gene

2 Reactome pathways for ZNF565 Gene

Interacting Proteins for ZNF565 Gene

Gene Ontology (GO) - Biological Process for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF565: view

No data available for SIGNOR curated interactions for ZNF565 Gene

Drugs & Compounds for ZNF565 Gene

(1) Drugs for ZNF565 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 387
genes like me logo Genes that share compounds with ZNF565: view

Transcripts for ZNF565 Gene

mRNA/cDNA for ZNF565 Gene

Unigene Clusters for ZNF565 Gene

Zinc finger protein 565:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF565 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for ZNF565 Gene

GeneLoc Exon Structure for
ZNF565
ECgene alternative splicing isoforms for
ZNF565

Expression for ZNF565 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF565 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF565 Gene:

ZNF565

SOURCE GeneReport for Unigene cluster for ZNF565 Gene:

Hs.596338

Evidence on tissue expression from TISSUES for ZNF565 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF565: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF565 Gene

Orthologs for ZNF565 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF565 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF565 34 33
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF565 33
  • 89.89 (n)
cow
(Bos Taurus)
Mammalia ZNF565 34 33
  • 88.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp84 16 33
  • 62.31 (n)
rat
(Rattus norvegicus)
Mammalia Zfp84 33
  • 61.34 (n)
Species where no ortholog for ZNF565 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF565 Gene

ENSEMBL:
Gene Tree for ZNF565 (if available)
TreeFam:
Gene Tree for ZNF565 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF565: view image

Paralogs for ZNF565 Gene

(552) SIMAP similar genes for ZNF565 Gene using alignment to 4 proteins:

  • ZN565_HUMAN
  • B3KQ35_HUMAN
  • K7EL42_HUMAN
  • K7ESE2_HUMAN
genes like me logo Genes that share paralogs with ZNF565: view

Variants for ZNF565 Gene

Sequence variations from dbSNP and Humsavar for ZNF565 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000053811 -- 36,213,760(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000097220 -- 36,185,627(-) C/G intron_variant
rs1000172701 -- 36,184,713(-) G/A intron_variant
rs1000228624 -- 36,212,630(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000232318 -- 36,185,369(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF565 Gene

Variant ID Type Subtype PubMed ID
esv1010122 CNV insertion 20482838
nsv509739 CNV insertion 20534489
nsv579425 CNV loss 21841781

Variation tolerance for ZNF565 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF565 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF565

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF565 Gene

Disorders for ZNF565 Gene

Additional Disease Information for ZNF565

No disorders were found for ZNF565 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF565 Gene

Publications for ZNF565 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF565 Gene

Sources for ZNF565 Gene

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