Aliases for ZNF565 Gene

Aliases for ZNF565 Gene

  • Zinc Finger Protein 565 2 3 4 5

External Ids for ZNF565 Gene

Previous GeneCards Identifiers for ZNF565 Gene

  • GC19M041366
  • GC19M041360
  • GC19M036673
  • GC19M033177
  • GC19M036371
  • GC19M036703
  • GC19M040548
  • GC19M040977
  • GC19M041398
  • GC19M036889
  • GC19M036906
  • GC19M037444
  • GC19M037784
  • GC19M038082
  • GC19M038370
  • GC19M038663
  • GC19M040158

Summaries for ZNF565 Gene

GeneCards Summary for ZNF565 Gene

ZNF565 (Zinc Finger Protein 565) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF571.

UniProtKB/Swiss-Prot Summary for ZNF565 Gene

Additional gene information for ZNF565 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF565 Gene

Genomics for ZNF565 Gene

GeneHancer (GH) Regulatory Elements for ZNF565 Gene

Promoters and enhancers for ZNF565 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036213 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 536.8 +30.6 30607 4.3 ZBTB40 ZNF217 SIN3A NRF1 MYC TCF12 POLR2G USF1 SP1 NCOR1 ZNF146 ZNF565 lnc-COX7A1-4 ZNF345 ZNF567 TMEM147-AS1 ZNF850 ZNF790 HAUS5 ZNF529
GH19J036245 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 802 1.3 HDAC2 MXI1 POLR2A PHF8 TCF12 ETS1 SIN3A SETDB1 NR3C1 CTCF ZNF565 piR-40154-084 piR-52261-125 LINC00665 ENSG00000267053 LOC728485 lnc-CAPNS1-3
GH19J036194 Promoter 0.3 EPDnew 500.2 +51.4 51430 0.1 ZNF565 LINC00665 ENSG00000200179 lnc-COX7A1-3 lnc-COX7A1-4
GH19J036247 Enhancer 0.2 Ensembl 500.7 -1.2 -1227 0.9 ZNF565 piR-40154-084 piR-52261-125 piR-49423-121
GH19J035897 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 30.4 +342.2 342199 13 ZBTB40 EP300 ZSCAN5C SIN3A NRF1 USF1 POLR2G SP1 RBAK PHF8 NFKBID TYROBP HCST ENSG00000280194 ZNF566 ZNF529 ZNF790 ZNF567 ZNF461 ZNF260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF565 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF565

Top Transcription factor binding sites by QIAGEN in the ZNF565 gene promoter:
  • HNF-4alpha1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ZNF565 Gene

Genomic Locations for ZNF565 Gene
64,198 bases
Minus strand
63,973 bases
Minus strand

Genomic View for ZNF565 Gene

Genes around ZNF565 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF565 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF565 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF565 Gene

Proteins for ZNF565 Gene

  • Protein details for ZNF565 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 565
    Protein Accession:
    Secondary Accessions:
    • B3KQ35
    • Q6NUS2

    Protein attributes for ZNF565 Gene

    539 amino acids
    Molecular mass:
    62445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF565 Gene


neXtProt entry for ZNF565 Gene

Post-translational modifications for ZNF565 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF565 Gene

Domains & Families for ZNF565 Gene

Gene Families for ZNF565 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF565 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF565 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 565 (ZN565_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF565: view

Function for ZNF565 Gene

Molecular function for ZNF565 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF565 Gene

Gene Ontology (GO) - Molecular Function for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF565: view
genes like me logo Genes that share phenotypes with ZNF565: view

Animal Models for ZNF565 Gene

MGI Knock Outs for ZNF565:
  • Zfp84 Zfp84<tm1b(KOMP)Wtsi>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF565 Gene

Localization for ZNF565 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF565 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF565 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF565: view

Pathways & Interactions for ZNF565 Gene

genes like me logo Genes that share pathways with ZNF565: view

Pathways by source for ZNF565 Gene

2 Reactome pathways for ZNF565 Gene
1 KEGG pathway for ZNF565 Gene

Interacting Proteins for ZNF565 Gene


Gene Ontology (GO) - Biological Process for ZNF565 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF565: view

No data available for SIGNOR curated interactions for ZNF565 Gene

Drugs & Compounds for ZNF565 Gene

(1) Drugs for ZNF565 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 418
genes like me logo Genes that share compounds with ZNF565: view

Transcripts for ZNF565 Gene

mRNA/cDNA for ZNF565 Gene

9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF565 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for ZNF565 Gene

GeneLoc Exon Structure for

Expression for ZNF565 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF565 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF565

SOURCE GeneReport for Unigene cluster for ZNF565 Gene:


Evidence on tissue expression from TISSUES for ZNF565 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF565: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF565 Gene

Orthologs for ZNF565 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF565 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF565 31 30
  • 99.8 (n)
(Canis familiaris)
Mammalia ZNF565 30
  • 89.89 (n)
(Bos Taurus)
Mammalia ZNF565 31 30
  • 88.35 (n)
(Mus musculus)
Mammalia Zfp84 17 30
  • 62.31 (n)
(Rattus norvegicus)
Mammalia Zfp84 30
  • 61.34 (n)
Species where no ortholog for ZNF565 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF565 Gene

Gene Tree for ZNF565 (if available)
Gene Tree for ZNF565 (if available)
Evolutionary constrained regions (ECRs) for ZNF565: view image

Paralogs for ZNF565 Gene

Paralogs for ZNF565 Gene

(552) SIMAP similar genes for ZNF565 Gene using alignment to 4 proteins:

  • ZN565_HUMAN
  • B3KQ35_HUMAN
  • K7EL42_HUMAN
genes like me logo Genes that share paralogs with ZNF565: view

Variants for ZNF565 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF565 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs4805162 - p.Ile228Thr

Additional dbSNP identifiers (rs#s) for ZNF565 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF565 Gene

Variant ID Type Subtype PubMed ID
esv1010122 CNV insertion 20482838
nsv509739 CNV insertion 20534489
nsv579425 CNV loss 21841781

Variation tolerance for ZNF565 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF565 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF565 Gene

Disorders for ZNF565 Gene

Additional Disease Information for ZNF565

No disorders were found for ZNF565 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF565 Gene

Publications for ZNF565 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 54

Products for ZNF565 Gene

Sources for ZNF565 Gene