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ZNF564 Gene(Protein Coding)

Zinc Finger Protein 564

GCID:
GC19M012526
GIFtS:
38
Genes Participants
UDN Logo

Aliases for ZNF564 Gene

Aliases for ZNF564 Gene

  • Zinc Finger Protein 564 2 3 5

External Ids for ZNF564 Gene

Previous GeneCards Identifiers for ZNF564 Gene

  • GC19M012498
  • GC19M012499
  • GC19M012572
  • GC19M012636
  • GC19M012208

Summaries for ZNF564 Gene

GeneCards Summary for ZNF564 Gene

ZNF564 (Zinc Finger Protein 564) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF136.

UniProtKB/Swiss-Prot for ZNF564 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF564 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF564 Gene

Genomics for ZNF564 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZNF564 Gene

Promoters and enhancers for ZNF564 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I012550 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 581.5 -0.3 -294 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF564 ENSG00000196826 LOC105372278 ZNF136 ZNF44 ZNF763 ZNF799 TRMT1 TRIR ZNF20
GH19I012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 76.2 -237.8 -237756 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 JUNB CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 WDR83OS TRMT1 ZNF700 TRIR
GH19I013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.8 -602.2 -602153 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 IER2 ENSG00000267598 CCDC130 ZNF136 ZNF44 TRMT1 ZNF709 ZNF564 ZNF791
GH19I012549 Enhancer 0.3 ENCODE 550.8 +1.8 1760 0.2 IKZF1 ENSG00000196826 ZNF564 ENSG00000269560 ENSG00000269693
GH19I012983 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 71.9 -433.3 -433260 3.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF136 ZNF625 ZNF442 ZNF844 CCDC130 ZNF564 ZNF799 WDR83OS ZNF788 ZNF709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF564 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF564 gene promoter:

Genomic Locations for ZNF564 Gene

Genomic Locations for ZNF564 Gene
chr19:12,525,370-12,551,542
(GRCh38/hg38)
Size:
26,173 bases
Orientation:
Minus strand
chr19:12,636,184-12,662,356
(GRCh37/hg19)

Genomic View for ZNF564 Gene

Genes around ZNF564 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF564 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF564 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF564 Gene

Proteins for ZNF564 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF564 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ8-ZN564_HUMAN
    Recommended name:
    Zinc finger protein 564
    Protein Accession:
    Q8TBZ8
    Secondary Accessions:
    • B9EGT4
    • Q6P1K6

    Protein attributes for ZNF564 Gene

    Size:
    553 amino acids
    Molecular mass:
    63735 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28367.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF564 Gene

Protein Expression for ZNF564 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF564 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF564 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF564 Gene

Domains & Families for ZNF564 Gene

Gene Families for ZNF564 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF564 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF564 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBZ8

UniProtKB/Swiss-Prot:

ZN564_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF564: view

Function for ZNF564 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF564 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF564 Gene

Gene Ontology (GO) - Molecular Function for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF564: view

Phenotypes for ZNF564 Gene

GenomeRNAi human phenotypes for ZNF564:
genes like me logo Genes that share phenotypes with ZNF564: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF564 Gene

Localization for ZNF564 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF564 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF564 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF564: view

Pathways & Interactions for ZNF564 Gene

SuperPathways for ZNF564 Gene

PathCards logo More details on SuperPathways for ZNF564
SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF564: view

Pathways by source for ZNF564 Gene

2 Reactome pathways for ZNF564 Gene

Gene Ontology (GO) - Biological Process for ZNF564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with ZNF564: view

No data available for SIGNOR curated interactions for ZNF564 Gene

Drugs & Compounds for ZNF564 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF564 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF564 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF564 Gene

Zinc finger protein 564:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF564 Gene

No ASD Table

Relevant External Links for ZNF564 Gene

GeneLoc Exon Structure for
ZNF564
ECgene alternative splicing isoforms for
ZNF564

Expression for ZNF564 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF564 Gene

mRNA expression in normal human tissues for ZNF564 Gene
mRNA expression by GTEx for ZNF564 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF564 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF564 Gene:

ZNF564

SOURCE GeneReport for Unigene cluster for ZNF564 Gene:

Hs.655615

Evidence on tissue expression from TISSUES for ZNF564 Gene

  • Intestine(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF564: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF564 Gene

Orthologs for ZNF564 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF564 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF564 33 34
  • 99.76 (n)
dog
(Canis familiaris)
 Mammalia LOC611075 33
  • 77.17 (n)
cow
(Bos Taurus)
 Mammalia ZNF709 33
  • 71.63 (n)
-- 34
  • 56 (a)
 ManyToMany
Species where no ortholog for ZNF564 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF564 Gene

ENSEMBL:
Gene Tree for ZNF564 (if available)
TreeFam:
Gene Tree for ZNF564 (if available)

Paralogs for ZNF564 Gene

Paralogs for ZNF564 Gene

(609) SIMAP similar genes for ZNF564 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF564: view

Variants for ZNF564 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ZNF564 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000004564 -- 12,550,386(-) T/G intron_variant
rs1000118934 -- 12,531,291(-) C/A/T intron_variant
rs1000161973 -- 12,547,113(-) A/G intron_variant
rs1000407186 -- 12,531,557(-) G/A intron_variant
rs1000621817 -- 12,541,408(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF564 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
esv2657782 CNV deletion 23128226
esv2669161 CNV deletion 23128226
esv2676012 CNV deletion 23128226
esv3643705 CNV loss 21293372
esv3643706 CNV loss 21293372
nsv2419 CNV deletion 18451855
nsv475741 CNV novel sequence insertion 20440878
nsv510755 CNV deletion 20534489
nsv828440 CNV loss 20364138
nsv960794 CNV duplication 23825009

Variation tolerance for ZNF564 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF564 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF564

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF564 Gene

Disorders for ZNF564 Gene

Additional Disease Information for ZNF564

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF564 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF564 Gene

Publications for ZNF564 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF564 Gene

Sources for ZNF564 Gene

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