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Aliases for ZNF563 Gene

Aliases for ZNF563 Gene

  • Zinc Finger Protein 563 2 3 5

External Ids for ZNF563 Gene

Previous GeneCards Identifiers for ZNF563 Gene

  • GC19M012291
  • GC19M012429
  • GC19M012004

Summaries for ZNF563 Gene

GeneCards Summary for ZNF563 Gene

ZNF563 (Zinc Finger Protein 563) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF443.

UniProtKB/Swiss-Prot for ZNF563 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF563 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF563 Gene

Genomics for ZNF563 Gene

GeneHancer (GH) Regulatory Elements for ZNF563 Gene

Promoters and enhancers for ZNF563 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012330 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 560.5 +15.8 15803 4.4 PKNOX1 FOXA2 SMAD1 MLX ARID4B DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF563 ZNF20 ZNF878 ZNF44 ZNF433 ZNF136 ZNF763 SYCE2 ZNF788 GC19M012347
GH19I012347 Enhancer 0.5 ENCODE 550.8 +1.0 1028 0.2 CTCF SMC3 REST RUNX3 RAD21 GC19M012347 PIR44087 ZNF563 ZNF442 PIR41330
GH19I013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.9 -805.6 -805565 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 ENSG00000267598 IER2 CCDC130 ZNF136 ZNF44 TRMT1 ZNF709 ZNF564 ZNF791
GH19I011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.9 +971.8 971810 6.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000267277 PIR61774 SWSAP1 ILF3 KRI1 ZNF627 ZNF136 ZNF442 ZNF844 ZNF44
GH19I012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.4 -441.2 -441168 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 JUNB CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 WDR83OS TRMT1 ZNF700 TRIR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF563 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF563 Gene

Genomic Locations for ZNF563 Gene
chr19:12,317,477-12,348,130
(GRCh38/hg38)
Size:
30,654 bases
Orientation:
Minus strand
chr19:12,428,291-12,444,534
(GRCh37/hg19)

Genomic View for ZNF563 Gene

Genes around ZNF563 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF563 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF563 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF563 Gene

Proteins for ZNF563 Gene

  • Protein details for ZNF563 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TA94-ZN563_HUMAN
    Recommended name:
    Zinc finger protein 563
    Protein Accession:
    Q8TA94
    Secondary Accessions:
    • B2R9E7
    • Q8NAT7

    Protein attributes for ZNF563 Gene

    Size:
    476 amino acids
    Molecular mass:
    55434 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF563 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF563 Gene

Post-translational modifications for ZNF563 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF563 Gene

Domains & Families for ZNF563 Gene

Gene Families for ZNF563 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF563 Gene

Suggested Antigen Peptide Sequences for ZNF563 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TA94

UniProtKB/Swiss-Prot:

ZN563_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF563: view

Function for ZNF563 Gene

Molecular function for ZNF563 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF563 Gene

Gene Ontology (GO) - Molecular Function for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF563: view
genes like me logo Genes that share phenotypes with ZNF563: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF563 Gene

Localization for ZNF563 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF563 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF563 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF563: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF563 Gene

Pathways & Interactions for ZNF563 Gene

SuperPathways for ZNF563 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF563: view

Pathways by source for ZNF563 Gene

2 Reactome pathways for ZNF563 Gene

Interacting Proteins for ZNF563 Gene

Gene Ontology (GO) - Biological Process for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF563: view

No data available for SIGNOR curated interactions for ZNF563 Gene

Drugs & Compounds for ZNF563 Gene

No Compound Related Data Available

Transcripts for ZNF563 Gene

mRNA/cDNA for ZNF563 Gene

Unigene Clusters for ZNF563 Gene

Zinc finger protein 563:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF563 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2:
SP3: -

Relevant External Links for ZNF563 Gene

GeneLoc Exon Structure for
ZNF563
ECgene alternative splicing isoforms for
ZNF563

Expression for ZNF563 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF563 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF563 Gene

This gene is overexpressed in Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF563 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF563 Gene:

ZNF563

SOURCE GeneReport for Unigene cluster for ZNF563 Gene:

Hs.663510

Evidence on tissue expression from TISSUES for ZNF563 Gene

  • Spleen(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF563: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF563 Gene

Orthologs for ZNF563 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF563 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF563 33 34
  • 99.72 (n)
mouse
(Mus musculus)
Mammalia Zfp563 33 16
  • 64.34 (n)
rat
(Rattus norvegicus)
Mammalia Zfp563 33
  • 64.19 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 47 (a)
ManyToMany
Species where no ortholog for ZNF563 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF563 Gene

ENSEMBL:
Gene Tree for ZNF563 (if available)
TreeFam:
Gene Tree for ZNF563 (if available)

Paralogs for ZNF563 Gene

(502) SIMAP similar genes for ZNF563 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF563: view

Variants for ZNF563 Gene

Sequence variations from dbSNP and Humsavar for ZNF563 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000038023 -- 12,337,734(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000062457 -- 12,331,496(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000111014 -- 12,343,360(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000127552 -- 12,337,322(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000478619 -- 12,317,848(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF563 Gene

Variant ID Type Subtype PubMed ID
esv2718192 CNV deletion 23290073
nsv961180 CNV duplication 23825009

Variation tolerance for ZNF563 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF563 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF563

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF563 Gene

Disorders for ZNF563 Gene

Additional Disease Information for ZNF563

No disorders were found for ZNF563 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF563 Gene

Publications for ZNF563 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for ZNF563 Gene

Sources for ZNF563 Gene

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