Aliases for ZNF563 Gene

Aliases for ZNF563 Gene

  • Zinc Finger Protein 563 2 3 4 5

External Ids for ZNF563 Gene

Previous GeneCards Identifiers for ZNF563 Gene

  • GC19M012291
  • GC19M012292
  • GC19M012429
  • GC19M012004

Summaries for ZNF563 Gene

GeneCards Summary for ZNF563 Gene

ZNF563 (Zinc Finger Protein 563) is a Protein Coding gene. Diseases associated with ZNF563 include Anus Cancer. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF443.

UniProtKB/Swiss-Prot Summary for ZNF563 Gene

Additional gene information for ZNF563 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF563 Gene

Genomics for ZNF563 Gene

GeneHancer (GH) Regulatory Elements for ZNF563 Gene

Promoters and enhancers for ZNF563 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012330 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.4 +15.8 15803 4.4 EP300 POLR2G SP1 NCOR1 FOS ZIC2 KDM6A POLR2A TCF7 REST ZNF563 ZNF136 TNPO2 ZNF788P lnc-ZNF442-1 piR-48331-001
GH19J012364 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -17.3 -17300 2.5 ZNF217 EP300 CTCF POLR2G SP1 NCOR1 GTF2E2 ZIC2 POLR2A CLOCK ZNF442 ZNF563 ZNF491 ZNF441 ZNF625 ZNF44 ZNF625-ZNF20 RPS6P25 DHPS ZNF788P
GH19J012347 Enhancer 0.5 ENCODE 500.7 +1.0 1028 0.2 REST RAD21 SMC3 CTCF ZNF652 RUNX3 ZNF563 lnc-ZNF442-1 piR-50088 ZNF442 piR-48331-001
GH19J013148 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 -805.3 -805262 10.8 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 STX10 ENSG00000267598 ENSG00000287296 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 ZNF442
GH19J012609 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.2 -263.9 -263945 5.4 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 MYC POLR2G SP1 NCOR1 ZNF490 ZNF791 piR-44933 ZNF136 ZNF20 ZNF44 FBXW9 ZNF799 ZNF700 ZNF441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF563 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF563

Genomic Locations for ZNF563 Gene

Genomic Locations for ZNF563 Gene
30,654 bases
Minus strand
16,244 bases
Minus strand

Genomic View for ZNF563 Gene

Genes around ZNF563 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF563 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF563 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF563 Gene

Proteins for ZNF563 Gene

  • Protein details for ZNF563 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 563
    Protein Accession:
    Secondary Accessions:
    • B2R9E7
    • Q8NAT7

    Protein attributes for ZNF563 Gene

    476 amino acids
    Molecular mass:
    55434 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF563 Gene


neXtProt entry for ZNF563 Gene

Post-translational modifications for ZNF563 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF563 Gene

Domains & Families for ZNF563 Gene

Gene Families for ZNF563 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF563 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF563 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 563 (ZN563_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF563: view

Function for ZNF563 Gene

Molecular function for ZNF563 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF563 Gene

Gene Ontology (GO) - Molecular Function for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF563: view
genes like me logo Genes that share phenotypes with ZNF563: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF563 Gene

Localization for ZNF563 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF563 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF563 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF563: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF563 Gene

Pathways & Interactions for ZNF563 Gene

genes like me logo Genes that share pathways with ZNF563: view

Pathways by source for ZNF563 Gene

2 Reactome pathways for ZNF563 Gene
1 KEGG pathway for ZNF563 Gene

Gene Ontology (GO) - Biological Process for ZNF563 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF563: view

No data available for SIGNOR curated interactions for ZNF563 Gene

Drugs & Compounds for ZNF563 Gene

No Compound Related Data Available

Transcripts for ZNF563 Gene

mRNA/cDNA for ZNF563 Gene

4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF563 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP3: -

Relevant External Links for ZNF563 Gene

GeneLoc Exon Structure for

Expression for ZNF563 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF563 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF563 Gene

This gene is overexpressed in Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF563 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF563

SOURCE GeneReport for Unigene cluster for ZNF563 Gene:


Evidence on tissue expression from TISSUES for ZNF563 Gene

  • Spleen(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF563: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF563 Gene

Orthologs for ZNF563 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF563 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF563 31 30
  • 99.72 (n)
(Mus musculus)
Mammalia Zfp563 17 30
  • 64.34 (n)
(Rattus norvegicus)
Mammalia Zfp563 30
  • 64.19 (n)
(Bos Taurus)
Mammalia -- 31
  • 47 (a)
Species where no ortholog for ZNF563 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF563 Gene

Gene Tree for ZNF563 (if available)
Gene Tree for ZNF563 (if available)
Evolutionary constrained regions (ECRs) for ZNF563: view image

Paralogs for ZNF563 Gene

(502) SIMAP similar genes for ZNF563 Gene using alignment to 3 proteins:

  • ZN563_HUMAN
  • M0R1L6_HUMAN
  • M0R1Q6_HUMAN
genes like me logo Genes that share paralogs with ZNF563: view

Variants for ZNF563 Gene

Additional dbSNP identifiers (rs#s) for ZNF563 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF563 Gene

Variant ID Type Subtype PubMed ID
esv2718192 CNV deletion 23290073
nsv961180 CNV duplication 23825009

Variation tolerance for ZNF563 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF563 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF563 Gene

Disorders for ZNF563 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF563 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anus cancer
  • anal cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF563

genes like me logo Genes that share disorders with ZNF563: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF563 Gene

Publications for ZNF563 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 54
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 54

Products for ZNF563 Gene

Sources for ZNF563 Gene