Aliases for ZNF561 Gene

Aliases for ZNF561 Gene

  • Zinc Finger Protein 561 2 3 4 5

External Ids for ZNF561 Gene

Previous GeneCards Identifiers for ZNF561 Gene

  • GC19M009582
  • GC19M009579
  • GC19M009715
  • GC19M009298

Summaries for ZNF561 Gene

GeneCards Summary for ZNF561 Gene

ZNF561 (Zinc Finger Protein 561) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot Summary for ZNF561 Gene

Additional gene information for ZNF561 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF561 Gene

Genomics for ZNF561 Gene

GeneHancer (GH) Regulatory Elements for ZNF561 Gene

Promoters and enhancers for ZNF561 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009620 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 824.2 -0.4 -381 3.6 SIN3A SP1 ZBTB40 SIX5 RBPJ POLR2A CTBP1 NR2F6 ATF1 CREB1 ZNF561 ZNF561-AS1 piR-30876-047 lnc-ZNF562-2 ZNF266 KRI1 ZNF699 PPAN FBXL12 ZNF558
GH19J009673 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 777.9 -53.3 -53260 3 ZBTB40 POLR2A ATF1 CREB1 HCFC1 ZNF362 ELF1 L3MBTL2 ZNF280D ZNF148 ZNF561 ZNF562 piR-43105-317 ILF3 DNMT1 ZNF177 ZNF699 PPAN RPS4XP22 KRI1
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 74.9 -799.7 -799676 10.6 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF ZBTB6 RBPJ SMARCE1 TCF7L2 PDE4A CDC37 ILF3 ZNF266 KRI1 DNMT1 LOC100419831 RAVER1 PPAN FBXL12
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 58.5 -483.1 -483147 8.3 GTF3C2 ZNF24 SP1 ZBTB40 SIX5 ZBTB6 MLX RBPJ POLR2A ATF1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 EIF3G ZNF266 FBXL12 KRI1 ILF3 ZNF317
GH19J010427 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 66.6 -809.3 -809325 6.5 GTF3C2 ZNF24 ZBTB40 SMARCE1 HDAC2 MYC CC2D1A ETV6 ELF1 RELA PDE4A piR-56480-029 ZNF266 ILF3 KRI1 FBXL12 ZNF561 RAVER1 EIF3G PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF561 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF561 gene promoter:
  • Bach2
  • C/EBPalpha
  • CHOP-10
  • GATA-1
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF561 Gene

Genomic Locations for ZNF561 Gene
16,561 bases
Minus strand
16,720 bases
Minus strand

Genomic View for ZNF561 Gene

Genes around ZNF561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF561 Gene

Proteins for ZNF561 Gene

  • Protein details for ZNF561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 561
    Protein Accession:
    Secondary Accessions:
    • B4E2Q8
    • Q6PJS0

    Protein attributes for ZNF561 Gene

    486 amino acids
    Molecular mass:
    55197 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF561 Gene


neXtProt entry for ZNF561 Gene

Post-translational modifications for ZNF561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF561 Gene

Domains & Families for ZNF561 Gene

Gene Families for ZNF561 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF561 Gene

Suggested Antigen Peptide Sequences for ZNF561 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77249, highly similar to Homo sapiens zinc finger protein 561 (ZNF561), mRNA (A8KAD9_HUMAN)
  • cDNA FLJ61555, highly similar to Zinc finger protein 561 (B4E2Q8_HUMAN)
  • Zinc finger protein 561 (ZN561_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF561: view

Function for ZNF561 Gene

Molecular function for ZNF561 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF561 Gene

Gene Ontology (GO) - Molecular Function for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF561: view
genes like me logo Genes that share phenotypes with ZNF561: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF561 Gene

Localization for ZNF561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF561 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF561 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF561: view

Pathways & Interactions for ZNF561 Gene

genes like me logo Genes that share pathways with ZNF561: view

Pathways by source for ZNF561 Gene

2 Reactome pathways for ZNF561 Gene
1 KEGG pathway for ZNF561 Gene

Gene Ontology (GO) - Biological Process for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF561: view

No data available for SIGNOR curated interactions for ZNF561 Gene

Drugs & Compounds for ZNF561 Gene

No Compound Related Data Available

Transcripts for ZNF561 Gene

mRNA/cDNA for ZNF561 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - -

Relevant External Links for ZNF561 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF561 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF561 Gene

Protein differential expression in normal tissues from HIPED for ZNF561 Gene

This gene is overexpressed in Lung (47.1), Heart (15.7), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF561 Gene

Protein tissue co-expression partners for ZNF561 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF561 Gene:


SOURCE GeneReport for Unigene cluster for ZNF561 Gene:


Evidence on tissue expression from TISSUES for ZNF561 Gene

  • Intestine(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF561: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF561 Gene

Orthologs for ZNF561 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF561 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF561 33 32
  • 99.04 (n)
(Mus musculus)
Mammalia Zfp266 33
  • 49 (a)
(Canis familiaris)
Mammalia -- 33
  • 40 (a)
(Bos Taurus)
Mammalia -- 33
  • 29 (a)
Species where no ortholog for ZNF561 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF561 Gene

Gene Tree for ZNF561 (if available)
Gene Tree for ZNF561 (if available)
Evolutionary constrained regions (ECRs) for ZNF561: view image

Paralogs for ZNF561 Gene

(529) SIMAP similar genes for ZNF561 Gene using alignment to 10 proteins:

  • ZN561_HUMAN
  • B4E2Q8_HUMAN
  • C9J7U2_HUMAN
  • F2Z3H5_HUMAN
  • F8W7U5_HUMAN
  • F8WBU1_HUMAN Pseudogenes for ZNF561 Gene

genes like me logo Genes that share paralogs with ZNF561: view

Variants for ZNF561 Gene

Sequence variations from dbSNP and Humsavar for ZNF561 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000193576 -- 9,613,596(-) G/A intron_variant
rs1000215047 -- 9,614,225(-) G/A intron_variant
rs1000380547 -- 9,616,737(-) A/C intron_variant
rs1000403905 -- 9,617,458(-) A/C intron_variant
rs1000463808 -- 9,607,328(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF561 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV deletion 23290073
esv994852 CNV insertion 20482838
nsv1060112 CNV gain 25217958
nsv138179 CNV deletion 16902084
nsv978769 CNV duplication 23825009

Variation tolerance for ZNF561 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF561 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF561 Gene

Disorders for ZNF561 Gene

Additional Disease Information for ZNF561

No disorders were found for ZNF561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF561 Gene

Publications for ZNF561 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for ZNF561 Gene

Sources for ZNF561 Gene