Aliases for ZNF561 Gene

Aliases for ZNF561 Gene

  • Zinc Finger Protein 561 2 3 4 5
  • MGC45408 2
  • ZNF561 5

External Ids for ZNF561 Gene

Previous GeneCards Identifiers for ZNF561 Gene

  • GC19M009582
  • GC19M009579
  • GC19M009715
  • GC19M009298

Summaries for ZNF561 Gene

GeneCards Summary for ZNF561 Gene

ZNF561 (Zinc Finger Protein 561) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot Summary for ZNF561 Gene

Additional gene information for ZNF561 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF561 Gene

Genomics for ZNF561 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF561 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF561 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF561

Top Transcription factor binding sites by QIAGEN in the ZNF561 gene promoter:
  • Bach2
  • C/EBPalpha
  • CHOP-10
  • GATA-1
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF561 Gene

Genomic Locations for ZNF561 Gene
chr19:9,604,680-9,621,249
(GRCh38/hg38)
Size:
16,570 bases
Orientation:
Minus strand
chr19:9,715,356-9,732,075
(GRCh37/hg19)
Size:
16,720 bases
Orientation:
Minus strand

Genomic View for ZNF561 Gene

Genes around ZNF561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF561 Gene

Proteins for ZNF561 Gene

  • Protein details for ZNF561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N587-ZN561_HUMAN
    Recommended name:
    Zinc finger protein 561
    Protein Accession:
    Q8N587
    Secondary Accessions:
    • B4E2Q8
    • Q6PJS0

    Protein attributes for ZNF561 Gene

    Size:
    486 amino acids
    Molecular mass:
    55197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12144.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF561 Gene

Post-translational modifications for ZNF561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF561 Gene

Domains & Families for ZNF561 Gene

Gene Families for ZNF561 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF561 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF561 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77249, highly similar to Homo sapiens zinc finger protein 561 (ZNF561), mRNA (A8KAD9_HUMAN)
  • cDNA FLJ61555, highly similar to Zinc finger protein 561 (B4E2Q8_HUMAN)
  • Zinc finger protein 561 (ZN561_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N587

UniProtKB/Swiss-Prot:

ZN561_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF561: view

Function for ZNF561 Gene

Molecular function for ZNF561 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF561 Gene

Gene Ontology (GO) - Molecular Function for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF561: view
genes like me logo Genes that share phenotypes with ZNF561: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF561

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF561 Gene

Localization for ZNF561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF561 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF561 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF561: view

Pathways & Interactions for ZNF561 Gene

genes like me logo Genes that share pathways with ZNF561: view

Pathways by source for ZNF561 Gene

2 Reactome pathways for ZNF561 Gene
1 KEGG pathway for ZNF561 Gene

Gene Ontology (GO) - Biological Process for ZNF561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF561: view

No data available for SIGNOR curated interactions for ZNF561 Gene

Drugs & Compounds for ZNF561 Gene

No Compound Related Data Available

Transcripts for ZNF561 Gene

mRNA/cDNA for ZNF561 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF561

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF561 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11:
SP12:

Relevant External Links for ZNF561 Gene

GeneLoc Exon Structure for
ZNF561

Expression for ZNF561 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF561 Gene

Protein differential expression in normal tissues from HIPED for ZNF561 Gene

This gene is overexpressed in Lung (47.1), Heart (15.7), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF561 Gene



Protein tissue co-expression partners for ZNF561 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF561

SOURCE GeneReport for Unigene cluster for ZNF561 Gene:

Hs.720081

Evidence on tissue expression from TISSUES for ZNF561 Gene

  • Skin(4.2)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZNF561: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF561 Gene

Orthologs for ZNF561 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF561 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF561 30 31
  • 99.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp266 31
  • 49 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 29 (a)
OneToMany
Species where no ortholog for ZNF561 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF561 Gene

ENSEMBL:
Gene Tree for ZNF561 (if available)
TreeFam:
Gene Tree for ZNF561 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF561: view image

Paralogs for ZNF561 Gene

(529) SIMAP similar genes for ZNF561 Gene using alignment to 10 proteins:

  • ZN561_HUMAN
  • A8KAD9_HUMAN
  • B4E2Q8_HUMAN
  • C9IZJ4_HUMAN
  • C9J7U2_HUMAN
  • C9JQP3_HUMAN
  • F2Z3H5_HUMAN
  • F8W7U5_HUMAN
  • F8WAU2_HUMAN
  • F8WBU1_HUMAN

Pseudogenes.org Pseudogenes for ZNF561 Gene

genes like me logo Genes that share paralogs with ZNF561: view

Variants for ZNF561 Gene

Additional dbSNP identifiers (rs#s) for ZNF561 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF561 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV deletion 23290073
esv994852 CNV insertion 20482838
nsv1060112 CNV gain 25217958
nsv138179 CNV deletion 16902084
nsv978769 CNV duplication 23825009

Variation tolerance for ZNF561 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF561 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF561

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF561 Gene

Disorders for ZNF561 Gene

No disorders were found for ZNF561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF561 Gene

Publications for ZNF561 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF561 Gene

Sources for ZNF561 Gene