Aliases for ZNF560 Gene

Aliases for ZNF560 Gene

  • Zinc Finger Protein 560 2 3 4 5

External Ids for ZNF560 Gene

Previous GeneCards Identifiers for ZNF560 Gene

  • GC19M009268
  • GC19M009438
  • GC19M009577
  • GC19M009158
  • GC19M009466

Summaries for ZNF560 Gene

GeneCards Summary for ZNF560 Gene

ZNF560 (Zinc Finger Protein 560) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot Summary for ZNF560 Gene

Additional gene information for ZNF560 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF560 Gene

Genomics for ZNF560 Gene

GeneHancer (GH) Regulatory Elements for ZNF560 Gene

Promoters and enhancers for ZNF560 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009497 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 506.6 +8.4 8388 1.8 CTCF ZBTB33 GABPA ZBTB40 GABPB1 CREM E2F1 ZNF560 ENSG00000267273 ENSG00000267612 piR-53431-325
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF560 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF560

Top Transcription factor binding sites by QIAGEN in the ZNF560 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • YY1

Genomic Locations for ZNF560 Gene

Genomic Locations for ZNF560 Gene
chr19:9,445,826-9,506,689
(GRCh38/hg38)
Size:
60,864 bases
Orientation:
Minus strand
chr19:9,577,031-9,609,283
(GRCh37/hg19)
Size:
32,253 bases
Orientation:
Minus strand

Genomic View for ZNF560 Gene

Genes around ZNF560 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF560 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF560 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF560 Gene

Proteins for ZNF560 Gene

  • Protein details for ZNF560 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MR9-ZN560_HUMAN
    Recommended name:
    Zinc finger protein 560
    Protein Accession:
    Q96MR9
    Secondary Accessions:
    • Q495S9
    • Q495T1

    Protein attributes for ZNF560 Gene

    Size:
    790 amino acids
    Molecular mass:
    91121 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF560 Gene

Post-translational modifications for ZNF560 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF560 Gene

Domains & Families for ZNF560 Gene

Gene Families for ZNF560 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF560 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF560 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 560 (ZN560_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96MR9

UniProtKB/Swiss-Prot:

ZN560_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF560: view

Function for ZNF560 Gene

Molecular function for ZNF560 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF560 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF560: view
genes like me logo Genes that share phenotypes with ZNF560: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF560 Gene

Localization for ZNF560 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF560 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF560 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF560 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF560: view

Pathways & Interactions for ZNF560 Gene

genes like me logo Genes that share pathways with ZNF560: view

Pathways by source for ZNF560 Gene

2 Reactome pathways for ZNF560 Gene
1 KEGG pathway for ZNF560 Gene

Interacting Proteins for ZNF560 Gene

;

Gene Ontology (GO) - Biological Process for ZNF560 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF560: view

No data available for SIGNOR curated interactions for ZNF560 Gene

Drugs & Compounds for ZNF560 Gene

No Compound Related Data Available

Transcripts for ZNF560 Gene

mRNA/cDNA for ZNF560 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF560 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:

Relevant External Links for ZNF560 Gene

GeneLoc Exon Structure for
ZNF560

Expression for ZNF560 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF560 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF560 Gene

This gene is overexpressed in Testis (x40.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF560 Gene



Protein tissue co-expression partners for ZNF560 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF560

SOURCE GeneReport for Unigene cluster for ZNF560 Gene:

Hs.631613
genes like me logo Genes that share expression patterns with ZNF560: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF560 Gene

Orthologs for ZNF560 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF560 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF560 31 30
  • 98.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp560 17 31 30
  • 67.3 (n)
rat
(Rattus norvegicus)
Mammalia Zfp560 30
  • 67.02 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 36 (a)
OneToMany
Species where no ortholog for ZNF560 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF560 Gene

ENSEMBL:
Gene Tree for ZNF560 (if available)
TreeFam:
Gene Tree for ZNF560 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF560: view image

Paralogs for ZNF560 Gene

(307) SIMAP similar genes for ZNF560 Gene using alignment to 1 proteins:

  • ZN560_HUMAN
genes like me logo Genes that share paralogs with ZNF560: view

Variants for ZNF560 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF560 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs193920939 Uncertain Significance: Malignant tumor of prostate 9,467,851(-) G/T MISSENSE_VARIANT
VAR_035588 A colorectal cancer sample p.Gly186Glu
rs10416098 - p.Tyr630Cys

Additional dbSNP identifiers (rs#s) for ZNF560 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF560 Gene

Variant ID Type Subtype PubMed ID
esv3343658 CNV insertion 20981092
esv995010 CNV deletion 20482838
nsv1131397 CNV deletion 24896259

Variation tolerance for ZNF560 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF560 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF560

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF560 Gene

Disorders for ZNF560 Gene

Additional Disease Information for ZNF560

No disorders were found for ZNF560 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF560 Gene

Publications for ZNF560 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis. (PMID: 24137329) Zhu H … Pei HP (Oncology letters 2013) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for ZNF560 Gene

Sources for ZNF560 Gene