Aliases for ZNF559-ZNF177 Gene
External Ids for ZNF559-ZNF177 Gene
- HGNC: 42964
- Entrez Gene: 100529215
- Ensembl: ENSG00000270011
Previous GeneCards Identifiers for ZNF559-ZNF177 Gene
- GC19U901491
- GC19P009435
Summaries for ZNF559-ZNF177 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]
GeneCards Summary for ZNF559-ZNF177 Gene
ZNF559-ZNF177 (ZNF559-ZNF177 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF177.
Additional gene information for ZNF559-ZNF177 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF559-ZNF177 Gene
Genomics for ZNF559-ZNF177 Gene
GeneHancer (GH) Regulatory Elements for ZNF559-ZNF177 Gene
Promoters and enhancers for ZNF559-ZNF177 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19I009323 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | 0.0 | -14 | 2.1 | PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 GTF3C2 POLR2B KLF7 FOS | ZNF559 PIR42397 ZNF559-ZNF177 PIR62532 GC19M009325 ZNF266 GC19M009317 | |
| GH19I009666 | Enhancer | 0.3 | FANTOM5 | 2.7 | +342.0 | 342040 | 0.4 | PIR46077 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF426 OLFM2 ZNF177 ZNF562 | ||
| GH19I009647 | Enhancer | 0.2 | FANTOM5 | 1.4 | +323.5 | 323511 | 0.3 | ZNF846 ZNF559 ZNF559-ZNF177 GC19P009643 PIR46077 ZNF562 | ||
| GH19I009638 | Enhancer | 0.2 | FANTOM5 | 1.4 | +314.2 | 314177 | 0.3 | PIR53474 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426 | ||
| GH19I009362 | Promoter | 0.9 | EPDnew | 0.3 | +38.8 | 38838 | 0.1 | L3MBTL2 NRF1 ZBTB11 ZBTB40 GABPA DIDO1 POLR2A GABPB1 VEZF1 HMGN3 | ZNF177 ZNF266 ZNF559 LOC100128428 ZNF559-ZNF177 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF559-ZNF177 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF559-ZNF177 Gene
Genomic Locations for ZNF559-ZNF177 Gene
- chr19:9,324,174-9,382,617
- (GRCh38/hg38)
- Size:
- 58,444 bases
- Orientation:
- Plus strand
- chr19:9,434,850-9,493,293
- (GRCh37/hg19)
Genomic View for ZNF559-ZNF177 Gene
Genes around ZNF559-ZNF177 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
ZNF559-ZNF177 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF559-ZNF177 Gene
Proteins for ZNF559-ZNF177 Gene
-
Protein details for ZNF559-ZNF177 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0A6YYI6
- Recommended name:
- Protein ZNF559-ZNF177
- Protein Accession:
- A0A0A6YYI6
Protein attributes for ZNF559-ZNF177 Gene
- Size:
- 481 amino acids
- Molecular mass:
- 54782 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF559-ZNF177 Gene
Post-translational modifications for ZNF559-ZNF177 Gene
No Post-translational modifications
Other Protein References for ZNF559-ZNF177 Gene
Protein Products
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Assay Products
No data available for DME Specific Peptides for ZNF559-ZNF177 Gene
Domains & Families for ZNF559-ZNF177 Gene
Gene Families for ZNF559-ZNF177 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF559-ZNF177 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene
Function for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0046872 | metal ion binding | IEA | -- |
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-
-
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CRISPR Products
- Browse CRISPR knockouts for ZNF559-ZNF177
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF559-ZNF177 gene related products
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-
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Cell Line Products
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF559-ZNF177 Gene
Localization for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0072562 | blood microparticle | HDA | 22516433 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF559-ZNF177 Gene
Pathways & Interactions for ZNF559-ZNF177 Gene
No Data Available
Interacting Proteins for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 8661005 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF559-ZNF177 Gene
Transcripts for ZNF559-ZNF177 Gene
mRNA/cDNA for ZNF559-ZNF177 Gene
- (2) REFSEQ mRNAs :
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF559-ZNF177 gene related products
- orf clones - Search results for available ZNF559-ZNF177 gene related products
- Applied Biological Materials Clones for ZNF559-ZNF177
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for ZNF559-ZNF177 Gene
- GeneLoc Exon Structure for
- ZNF559-ZNF177
- ECgene alternative splicing isoforms for
- ZNF559-ZNF177
Expression for ZNF559-ZNF177 Gene
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for ZNF559-ZNF177 Gene
Primer Products
- genomics-online: primer clones - Search results for available ZNF559-ZNF177 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF559-ZNF177 Gene
Orthologs for ZNF559-ZNF177 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | LOC102639598 33 |
|
||
| Zfp931 34 |
|
ManyToMany | |||
| Zfp965 16 |
|
|
|||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ZNF557 34 |
|
OneToMany |
- Species where no ortholog for ZNF559-ZNF177 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZNF559-ZNF177 Gene
- ENSEMBL:
- Gene Tree for ZNF559-ZNF177 (if available)
- TreeFam:
- Gene Tree for ZNF559-ZNF177 (if available)
Paralogs for ZNF559-ZNF177 Gene
Variants for ZNF559-ZNF177 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013275 | -- | 9,325,018(+) | C/G | intron_variant | |
| rs1000063428 | -- | 9,355,916(+) | C/T | intron_variant | |
| rs1000065651 | -- | 9,323,089(+) | A/C | upstream_transcript_variant | |
| rs1000102397 | -- | 9,362,998(+) | C/T | intron_variant | |
| rs1000103492 | -- | 9,327,484(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.97;
36.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF559-ZNF177 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF559-ZNF177
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene
Disorders for ZNF559-ZNF177 Gene
Additional Disease Information for ZNF559-ZNF177
No disorders were found for ZNF559-ZNF177 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF559-ZNF177 Gene
Publications for ZNF559-ZNF177 Gene
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P … Falcon-Perez JM (Journal of proteomics 2012) 3 58
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for ZNF559-ZNF177 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available ZNF559-ZNF177 related products ranked by validation data
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Sources for ZNF559-ZNF177 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems