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This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSe... See more...
Aliases for ZNF559-ZNF177 Gene
Aliases for ZNF559-ZNF177 Gene
External Ids for ZNF559-ZNF177 Gene
Previous GeneCards Identifiers for ZNF559-ZNF177 Gene
- GC19U901491
- GC19P009435
Summaries for ZNF559-ZNF177 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]
GeneCards Summary for ZNF559-ZNF177 Gene
ZNF559-ZNF177 (ZNF559-ZNF177 Readthrough) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF177.
Additional gene information for ZNF559-ZNF177 Gene
- HGNC(42964)
- Entrez Gene(100529215)
- Ensembl(ENSG00000270011)
- UniProtKB(S4R367)
- UniProtKB(S4R3A1)
- UniProtKB(S4R3B1)
- UniProtKB(S4R342)
- UniProtKB(S4R3H7)
- UniProtKB(S4R3Q2)
- UniProtKB(S4R365)
- UniProtKB(S4R401)
- UniProtKB(S4R3T9)
- UniProtKB(S4R422)
- Open Targets Platform(ENSG00000270011)
- Search for ZNF559-ZNF177 at DataMed
- Search for ZNF559-ZNF177 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF559-ZNF177 Gene
Genomics for ZNF559-ZNF177 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF559-ZNF177 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF559-ZNF177 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF559-ZNF177
Genomic Locations for ZNF559-ZNF177 Gene
Genomic Locations for ZNF559-ZNF177 Gene
- chr19:9,324,174-9,382,617
- (GRCh38/hg38)
- Size:
- 58,444 bases
- Orientation:
- Plus strand
- chr19:9,434,850-9,493,293
- (GRCh37/hg19)
- Size:
- 58,444 bases
- Orientation:
- Plus strand
Genomic View for ZNF559-ZNF177 Gene
Genes around ZNF559-ZNF177 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
ZNF559-ZNF177 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF559-ZNF177 Gene
Proteins for ZNF559-ZNF177 Gene
-
Protein details for ZNF559-ZNF177 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- S4R367-S4R367_HUMAN
- Recommended name:
- ZNF559-ZNF177 readthrough
- Protein Accession:
- S4R367
Protein attributes for ZNF559-ZNF177 Gene
- Size:
- 47 amino acids
- Molecular mass:
- 5290 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF559-ZNF177 Gene
Post-translational modifications for ZNF559-ZNF177 Gene
No Post-translational modifications
Other Protein References for ZNF559-ZNF177 Gene
Antibody Products
Protein Products
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No data available for DME Specific Peptides for ZNF559-ZNF177 Gene
Domains & Families for ZNF559-ZNF177 Gene
Gene Families for ZNF559-ZNF177 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF559-ZNF177 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene
Function for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0043565 | sequence-specific DNA binding | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Animal Model Products
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CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF559-ZNF177 - Select products 50% OFF >
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-
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miRNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for ZNF559-ZNF177
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF559-ZNF177 Gene
Localization for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0072562 | blood microparticle | HDA | 22516433 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF559-ZNF177 Gene
Pathways & Interactions for ZNF559-ZNF177 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Herpes simplex virus 1 infection | ||
Pathways by source for ZNF559-ZNF177 Gene
1 KEGG pathway for ZNF559-ZNF177 Gene
Interacting Proteins for ZNF559-ZNF177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 8661005 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for ZNF559-ZNF177 Gene
Transcripts for ZNF559-ZNF177 Gene
mRNA/cDNA for ZNF559-ZNF177 Gene
- 2 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000446085 2470 nts (view in UCSC)
- ENST00000541595 2435 nts (view in UCSC)
- ENST00000593242 586 nts (view in UCSC)
- ENST00000603024 610 nts (view in UCSC)
- ENST00000603099 584 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF559-ZNF177 - Select products 50% OFF >
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-
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miRNA Products
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Clone Products
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Relevant External Links for ZNF559-ZNF177 Gene
- GeneLoc Exon Structure for
- ZNF559-ZNF177
Expression for ZNF559-ZNF177 Gene
This gene is overexpressed in Plasma (69.0).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF559-ZNF177
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF559-ZNF177 Gene
Orthologs for ZNF559-ZNF177 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | LOC102639598 30 |
|
||
| Zfp931 17 31 |
|
ManyToMany | |||
| Gm14296 17 |
|
|
|||
| Zfp965 17 |
|
||||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | ZNF557 31 |
|
OneToMany |
- Species where no ortholog for ZNF559-ZNF177 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for ZNF559-ZNF177 Gene
Paralogs for ZNF559-ZNF177 Gene
- ZNF177 5
- ZNF778 5
- ZNF559 5
- ZNF560 5
- ZNF891 5
- ZFP90 5
- ZFP37 5
- ZNF674 5
- ZNF555 5
- ZNF554 5
- ZNF596 5
- ZNF20 5
- ZNF614 5
- ZNF805 5
- ZNF599 5
- ZNF582 5
- ZNF264 5
- ZNF248 5
- ZNF25 5
- ZNF180 5
- ZNF529 5
- ZNF266 5
- ZNF684 5
- ZNF404 5
- ZFP69B 5
- ZNF343 5
- ZNF619 5
- ZFP69 5
- ZNF558 5
- ZNF875 5
- ZNF440 5
- ZNF10 5
- ZNF19 5
- ZNF439 5
- ZNF749 5
- ZNF557 5
- ZNF337 5
- ZNF35 5
- ZNF77 5
- ZNF566 5
- ZNF846 5
- ZNF556 5
- ZNF329 5
- ZNF169 5
- ZNF133 5
- ZNF425 5
- ZNF70 5
- ZNF124 5
- PRDM9 5
- ENSG00000267179 5
- ZNF763 5
- ZNF620 5
- ZNF669 5
- ZNF491 5
- ZNF550 5
- ZNF80 5
- ZNF705A 5
- ZNF705E 5
- ZNF705G 5
- ZNF705B 5
- ZNF705D 5
- ZNF487 5
- KRBOX4 5
- ENSG00000256825 5
- ENSG00000261611 5
- ZNF589 5
- ENSG00000256566 5
- ZNF69 5
Variants for ZNF559-ZNF177 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF559-ZNF177 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714760 | Benign: not provided | 9,338,566(+) | T/G | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.97;
36.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF559-ZNF177 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF559-ZNF177
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene
Disorders for ZNF559-ZNF177 Gene
Additional Disease Information for ZNF559-ZNF177
No disorders were found for ZNF559-ZNF177 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF559-ZNF177 Gene
Publications for ZNF559-ZNF177 Gene
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
- Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P … Falcon-Perez JM (Journal of proteomics 2012) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
Products for ZNF559-ZNF177 Gene
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Sources for ZNF559-ZNF177 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
- (144) GlyConnect
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- (159) GeneImprint
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (177) snoDB
- (178) MirGeneDB