This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSe... See more...

Aliases for ZNF559-ZNF177 Gene

Aliases for ZNF559-ZNF177 Gene

  • ZNF559-ZNF177 Readthrough 2 3 5 13
  • Zinc Finger Protein 177 3
  • ZNF559-ZNF177 5

External Ids for ZNF559-ZNF177 Gene

Previous GeneCards Identifiers for ZNF559-ZNF177 Gene

  • GC19U901491
  • GC19P009435

Summaries for ZNF559-ZNF177 Gene

Entrez Gene Summary for ZNF559-ZNF177 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF559-ZNF177 Gene

ZNF559-ZNF177 (ZNF559-ZNF177 Readthrough) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF177.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF559-ZNF177 Gene

Genomics for ZNF559-ZNF177 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF559-ZNF177 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009323 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 127 3 BRCA1 SP1 CTCF PRDM10 IKZF1 POLR2A FOXA1 PHF21A RBFOX2 PKNOX1 ZNF559 NONHSAG024732.2 ZNF559-ZNF177 piR-39487 piR-49398 ZNF177 ZNF266 lnc-ZNF177-2
GH19J009666 Enhancer 0.5 FANTOM5 Ensembl 2.7 +342.3 342329 1 PHB2 piR-52078 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF177 ZNF426 OLFM2 ZNF562
GH19J009647 Enhancer 0.4 FANTOM5 Ensembl 1.4 +323.6 323627 0.8 piR-38423-023 piR-44110-026 ZNF846 ZNF559 ZNF559-ZNF177 RF00017-2798 lnc-ZNF561-1 ZNF561 ZNF562
GH19J009362 Promoter 1.4 EPDnew Ensembl CraniofacialAtlas 0.3 +38.9 38889 1.1 GATAD2B KDM4B ZBTB40 ZBTB11 GABPA VEZF1 NRF1 YY1 DIDO1 CHD2 ZNF177 ZNF266 ZNF559 piR-43105-316 ZNF559-ZNF177
GH19J009638 Enhancer 0.2 FANTOM5 1.4 +314.2 314177 0.3 piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF559-ZNF177 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF559-ZNF177

Genomic Locations for ZNF559-ZNF177 Gene

Genomic Locations for ZNF559-ZNF177 Gene
chr19:9,324,174-9,382,617
(GRCh38/hg38)
Size:
58,444 bases
Orientation:
Plus strand
chr19:9,434,850-9,493,293
(GRCh37/hg19)
Size:
58,444 bases
Orientation:
Plus strand

Genomic View for ZNF559-ZNF177 Gene

Genes around ZNF559-ZNF177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF559-ZNF177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF559-ZNF177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF559-ZNF177 Gene

Proteins for ZNF559-ZNF177 Gene

  • Protein details for ZNF559-ZNF177 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R367-S4R367_HUMAN
    Recommended name:
    ZNF559-ZNF177 readthrough
    Protein Accession:
    S4R367

    Protein attributes for ZNF559-ZNF177 Gene

    Size:
    47 amino acids
    Molecular mass:
    5290 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF559-ZNF177 Gene

Protein Expression for ZNF559-ZNF177 Gene

Post-translational modifications for ZNF559-ZNF177 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF559-ZNF177 Gene

Domains & Families for ZNF559-ZNF177 Gene

Gene Families for ZNF559-ZNF177 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF559-ZNF177 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with ZNF559-ZNF177: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

Function for ZNF559-ZNF177 Gene

Gene Ontology (GO) - Molecular Function for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF559-ZNF177

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF559-ZNF177 Gene

Localization for ZNF559-ZNF177 Gene

Gene Ontology (GO) - Cellular Components for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF559-ZNF177 Gene

Pathways & Interactions for ZNF559-ZNF177 Gene

PathCards logo

SuperPathways for ZNF559-ZNF177 Gene

genes like me logo Genes that share pathways with ZNF559-ZNF177: view

Pathways by source for ZNF559-ZNF177 Gene

1 KEGG pathway for ZNF559-ZNF177 Gene

Interacting Proteins for ZNF559-ZNF177 Gene

Gene Ontology (GO) - Biological Process for ZNF559-ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 8661005
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF559-ZNF177: view

No data available for SIGNOR curated interactions for ZNF559-ZNF177 Gene

Drugs & Compounds for ZNF559-ZNF177 Gene

No Compound Related Data Available

Transcripts for ZNF559-ZNF177 Gene

mRNA/cDNA for ZNF559-ZNF177 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF559-ZNF177

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF559-ZNF177 Gene

No ASD Table

Relevant External Links for ZNF559-ZNF177 Gene

GeneLoc Exon Structure for
ZNF559-ZNF177

Expression for ZNF559-ZNF177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF559-ZNF177 Gene

Protein differential expression in normal tissues from HIPED for ZNF559-ZNF177 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for ZNF559-ZNF177 Gene



Protein tissue co-expression partners for ZNF559-ZNF177 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF559-ZNF177

genes like me logo Genes that share expression patterns with ZNF559-ZNF177: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF559-ZNF177 Gene

Orthologs for ZNF559-ZNF177 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF559-ZNF177 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia LOC102639598 30
  • 59.86 (n)
Zfp931 17 31
  • 42 (a)
ManyToMany
Gm14296 17
Zfp965 17
Cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 47 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 42 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 23 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 25 (a)
OneToMany
Species where no ortholog for ZNF559-ZNF177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF559-ZNF177 Gene

ENSEMBL:
Gene Tree for ZNF559-ZNF177 (if available)
TreeFam:
Gene Tree for ZNF559-ZNF177 (if available)

Paralogs for ZNF559-ZNF177 Gene

Variants for ZNF559-ZNF177 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF559-ZNF177 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
714760 Benign: not provided 9,338,566(+) T/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF559-ZNF177 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF559-ZNF177 Gene

Variant ID Type Subtype PubMed ID
esv2674742 CNV deletion 23128226
esv2678521 CNV deletion 23128226
esv3643633 CNV loss 21293372
nsv521091 CNV loss 19592680
nsv523472 CNV loss 19592680
nsv819521 CNV gain 19587683
nsv961176 CNV duplication 23825009
nsv963002 CNV duplication 23825009

Variation tolerance for ZNF559-ZNF177 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF559-ZNF177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF559-ZNF177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559-ZNF177 Gene

Disorders for ZNF559-ZNF177 Gene

No disorders were found for ZNF559-ZNF177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF559-ZNF177 Gene

Publications for ZNF559-ZNF177 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P … Falcon-Perez JM (Journal of proteomics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3

Products for ZNF559-ZNF177 Gene

Sources for ZNF559-ZNF177 Gene