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Aliases for ZNF559 Gene

Aliases for ZNF559 Gene

  • Zinc Finger Protein 559 2 3 4 5
  • Putative Protein Product Of Nbla00121 3
  • NBLA00121 3

External Ids for ZNF559 Gene

Previous GeneCards Identifiers for ZNF559 Gene

  • GC19P009296
  • GC19P009434
  • GC19P009016

Summaries for ZNF559 Gene

GeneCards Summary for ZNF559 Gene

ZNF559 (Zinc Finger Protein 559) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot for ZNF559 Gene

Additional gene information for ZNF559 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF559 Gene

Genomics for ZNF559 Gene

GeneHancer (GH) Regulatory Elements for ZNF559 Gene

Promoters and enhancers for ZNF559 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009323 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 653.1 +0.5 529 2.6 CC2D1A SP1 ZFX YY1 EGR1 KAT8 POLR2A GMEB1 IKZF1 ZBTB8A ZNF559 GC19M009325 PIR62532 PIR42397 ZNF559-ZNF177 ZNF177 ZNF266 GC19M009317
GH19J010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 57.1 +780.6 780615 8.3 SP1 ZFX MNT SIX5 CBFA2T2 NKRF POLR2A ZNF121 CEBPG GTF2F1 PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 KRI1 FBXL12 ZNF317 LOC100419831 ZNF561
GH19J010110 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 71.8 +789.3 789256 5.2 SP1 CTCF POLR2A ZNF687 ZSCAN21 ZBTB7A KLF14 CREM EGR1 RAD21 P2RY11 GC19P010140 PIR48091 ILF3 ZNF699 ZNF266 ZNF559 ZNF317 DNMT1 LOC100419831
GH19J008361 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.6 -958.6 -958612 7.1 SP1 ZNF148 POLR2A MLLT1 ZNF121 GTF2F1 NFIB ZSCAN21 ZNF24 MAFK ANGPTL4 HNRNPM ZNF317 XAB2 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF559 ZNF414
GH19J010285 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.9 +966.1 966083 7.9 HDGF SP1 ZFX ZNF148 NKRF MLLT1 ZNF121 CEBPG GTF2F1 ZNF687 ICAM5 ENSG00000267607 GC19P010288 GC19P010291 ICAM4 ILF3 ZNF266 ZNF699 KRI1 FBXL12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF559 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF559 Gene

Genomic Locations for ZNF559 Gene
chr19:9,323,772-9,351,162
(GRCh38/hg38)
Size:
27,391 bases
Orientation:
Plus strand
chr19:9,434,448-9,461,838
(GRCh37/hg19)
Size:
27,391 bases
Orientation:
Plus strand

Genomic View for ZNF559 Gene

Genes around ZNF559 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF559 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF559 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF559 Gene

Proteins for ZNF559 Gene

  • Protein details for ZNF559 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR84-ZN559_HUMAN
    Recommended name:
    Zinc finger protein 559
    Protein Accession:
    Q9BR84
    Secondary Accessions:
    • K7EMG6

    Protein attributes for ZNF559 Gene

    Size:
    538 amino acids
    Molecular mass:
    62318 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF559 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF559 Gene

Post-translational modifications for ZNF559 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF559 Gene

Domains & Families for ZNF559 Gene

Gene Families for ZNF559 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF559 Gene

Suggested Antigen Peptide Sequences for ZNF559 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59365, highly similar to Zinc finger protein 559 (B4DP29_HUMAN)
  • Zinc finger protein 559 (ZN559_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BR84

UniProtKB/Swiss-Prot:

ZN559_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF559: view

Function for ZNF559 Gene

Molecular function for ZNF559 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF559 Gene

Gene Ontology (GO) - Molecular Function for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF559: view
genes like me logo Genes that share phenotypes with ZNF559: view

Animal Model Products

CRISPR Products

miRNA for ZNF559 Gene

miRTarBase miRNAs that target ZNF559

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF559 - Now 50% OFF >
  • * ZNF559 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF559 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF559 Gene

Localization for ZNF559 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF559 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF559 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF559: view

Pathways & Interactions for ZNF559 Gene

genes like me logo Genes that share pathways with ZNF559: view

Pathways by source for ZNF559 Gene

2 Reactome pathways for ZNF559 Gene
1 KEGG pathway for ZNF559 Gene

Gene Ontology (GO) - Biological Process for ZNF559 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF559: view

No data available for SIGNOR curated interactions for ZNF559 Gene

Drugs & Compounds for ZNF559 Gene

No Compound Related Data Available

Transcripts for ZNF559 Gene

Unigene Clusters for ZNF559 Gene

Zinc finger protein 559:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF559 - Now 50% OFF >
  • * ZNF559 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF559 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF559 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - -
SP20: - - - - -
SP21: - - - - -
SP22: - - - -
SP23: - - - - - - - -
SP24: - - - - - - - - - - - - - - -
SP25: - -

ExUns: 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i · 11j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ZNF559 Gene

GeneLoc Exon Structure for
ZNF559
ECgene alternative splicing isoforms for
ZNF559

Expression for ZNF559 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF559 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF559 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for ZNF559 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF559 Gene



Protein tissue co-expression partners for ZNF559 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF559 Gene:

ZNF559

SOURCE GeneReport for Unigene cluster for ZNF559 Gene:

Hs.172979

Evidence on tissue expression from TISSUES for ZNF559 Gene

  • Nervous system(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ZNF559: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF559 Gene

Orthologs for ZNF559 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF559 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF559 34
  • 99.48 (n)
-- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
Species where no ortholog for ZNF559 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF559 Gene

ENSEMBL:
Gene Tree for ZNF559 (if available)
TreeFam:
Gene Tree for ZNF559 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF559: view image

Paralogs for ZNF559 Gene

(540) SIMAP similar genes for ZNF559 Gene using alignment to 10 proteins:

  • ZN559_HUMAN
  • B4DP29_HUMAN
  • K7EK98_HUMAN
  • K7EKU6_HUMAN
  • K7EM21_HUMAN
  • K7EN17_HUMAN
  • K7EQI4_HUMAN
  • K7ERK9_HUMAN
  • S4R3F2_HUMAN
  • S4R3U0_HUMAN
genes like me logo Genes that share paralogs with ZNF559: view

Variants for ZNF559 Gene

Sequence variations from dbSNP and Humsavar for ZNF559 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000013275 -- 9,325,018(+) C/G intron_variant
rs1000065651 -- 9,323,089(+) A/C upstream_transcript_variant
rs1000103492 -- 9,327,484(+) G/A intron_variant
rs1000179104 -- 9,344,239(+) AAAAAAA/AA/AAAAA/AAAAAAAA downstream_transcript_variant
rs1000246152 -- 9,341,413(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF559 Gene

Variant ID Type Subtype PubMed ID
esv2674742 CNV deletion 23128226
esv2678521 CNV deletion 23128226
esv3643633 CNV loss 21293372
nsv521091 CNV loss 19592680
nsv523472 CNV loss 19592680
nsv819521 CNV gain 19587683
nsv961176 CNV duplication 23825009
nsv963002 CNV duplication 23825009

Variation tolerance for ZNF559 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF559 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF559
Human Gene Mutation Database (HGMD)
ZNF559

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF559 Gene

Disorders for ZNF559 Gene

Additional Disease Information for ZNF559

No disorders were found for ZNF559 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF559 Gene

Publications for ZNF559 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58

Products for ZNF559 Gene

Sources for ZNF559 Gene

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