Aliases for ZNF558 Gene

Aliases for ZNF558 Gene

  • Zinc Finger Protein 558 2 3 4 5
  • FLJ30932 2
  • ZNF558 5

External Ids for ZNF558 Gene

Previous GeneCards Identifiers for ZNF558 Gene

  • GC19M008782
  • GC19M008784
  • GC19M008920
  • GC19M008497

Summaries for ZNF558 Gene

GeneCards Summary for ZNF558 Gene

ZNF558 (Zinc Finger Protein 558) is a Protein Coding gene. Diseases associated with ZNF558 include Hereditary Breast Ovarian Cancer Syndrome and Fundus Dystrophy. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF557.

UniProtKB/Swiss-Prot Summary for ZNF558 Gene

Additional gene information for ZNF558 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF558 Gene

Genomics for ZNF558 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF558 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF558 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF558

Top Transcription factor binding sites by QIAGEN in the ZNF558 gene promoter:
  • AML1a
  • Bach1
  • GATA-1
  • HNF-3beta
  • LCR-F1
  • p53
  • RORalpha1
  • RORalpha2
  • TBP

Genomic Locations for ZNF558 Gene

Genomic Locations for ZNF558 Gene
chr19:8,806,170-8,838,144
(GRCh38/hg38)
Size:
31,975 bases
Orientation:
Minus strand
chr19:8,920,380-8,943,004
(GRCh37/hg19)
Size:
22,625 bases
Orientation:
Minus strand

Genomic View for ZNF558 Gene

Genes around ZNF558 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF558 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF558 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF558 Gene

Proteins for ZNF558 Gene

  • Protein details for ZNF558 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NG5-ZN558_HUMAN
    Recommended name:
    Zinc finger protein 558
    Protein Accession:
    Q96NG5
    Secondary Accessions:
    • A8K5F0
    • B7Z798

    Protein attributes for ZNF558 Gene

    Size:
    402 amino acids
    Molecular mass:
    45755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF558 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF558 Gene

Post-translational modifications for ZNF558 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF558 Gene

Domains & Families for ZNF558 Gene

Gene Families for ZNF558 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF558 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF558 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 558 (ZN558_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NG5

UniProtKB/Swiss-Prot:

ZN558_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF558: view

Function for ZNF558 Gene

Molecular function for ZNF558 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF558 Gene

Gene Ontology (GO) - Molecular Function for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF558: view
genes like me logo Genes that share phenotypes with ZNF558: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF558

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF558 Gene

Localization for ZNF558 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF558 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF558 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF558: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF558 Gene

Pathways & Interactions for ZNF558 Gene

genes like me logo Genes that share pathways with ZNF558: view

Pathways by source for ZNF558 Gene

2 Reactome pathways for ZNF558 Gene
1 KEGG pathway for ZNF558 Gene

Gene Ontology (GO) - Biological Process for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF558: view

No data available for SIGNOR curated interactions for ZNF558 Gene

Drugs & Compounds for ZNF558 Gene

No Compound Related Data Available

Transcripts for ZNF558 Gene

mRNA/cDNA for ZNF558 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF558

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF558 Gene

No ASD Table

Relevant External Links for ZNF558 Gene

GeneLoc Exon Structure for
ZNF558

Expression for ZNF558 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF558 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for ZNF558 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF558 Gene



Protein tissue co-expression partners for ZNF558 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF558

SOURCE GeneReport for Unigene cluster for ZNF558 Gene:

Hs.659797

Evidence on tissue expression from TISSUES for ZNF558 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF558: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF558 Gene

Orthologs for ZNF558 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF558 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF558 30 31
  • 98.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF558 30 31
  • 86.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF558 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp558 30 17 31
  • 82.26 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 25 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 20 (a)
OneToMany
Species where no ortholog for ZNF558 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF558 Gene

ENSEMBL:
Gene Tree for ZNF558 (if available)
TreeFam:
Gene Tree for ZNF558 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF558: view image

Paralogs for ZNF558 Gene

(535) SIMAP similar genes for ZNF558 Gene using alignment to 2 proteins:

  • ZN558_HUMAN
  • B7Z798_HUMAN

Pseudogenes.org Pseudogenes for ZNF558 Gene

genes like me logo Genes that share paralogs with ZNF558: view

Variants for ZNF558 Gene

Additional dbSNP identifiers (rs#s) for ZNF558 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF558 Gene

Variant ID Type Subtype PubMed ID
dgv48n68 CNV gain 17160897
esv2758744 CNV gain+loss 17122850
esv2762024 CNV gain 21179565
nsv1059126 CNV gain 25217958
nsv171 CNV deletion 15895083
nsv2402 CNV deletion 18451855
nsv428362 CNV gain+loss 18775914
nsv469648 CNV gain+loss 16826518
nsv483078 CNV gain+loss 15286789
nsv833738 CNV gain 17160897
nsv833739 CNV gain+loss 17160897

Variation tolerance for ZNF558 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF558 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF558

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF558 Gene

Disorders for ZNF558 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF558 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF558: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF558 Gene

Publications for ZNF558 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for ZNF558 Gene

Sources for ZNF558 Gene