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Aliases for ZNF558 Gene

Aliases for ZNF558 Gene

  • Zinc Finger Protein 558 2 3 5

External Ids for ZNF558 Gene

Previous GeneCards Identifiers for ZNF558 Gene

  • GC19M008782
  • GC19M008920
  • GC19M008497

Summaries for ZNF558 Gene

GeneCards Summary for ZNF558 Gene

ZNF558 (Zinc Finger Protein 558) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF557.

UniProtKB/Swiss-Prot for ZNF558 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF558 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF558 Gene

Genomics for ZNF558 Gene

GeneHancer (GH) Regulatory Elements for ZNF558 Gene

Promoters and enhancers for ZNF558 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I008831 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.6 0.0 -43 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 KLF13 ZNF558 ENSG00000269400 MBD3L1 ZNF177 ENSG00000267510 ZNF559 LOC100419831
GH19I008239 Enhancer 1.5 Ensembl ENCODE dbSUPER 98.9 +591.9 591904 2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 ENSG00000271717 ZNF558 HNRNPM ELAVL1 ZNF317 ENSG00000269300 XAB2 ZNF414 CERS4 ARHGEF18
GH19I008361 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 57.8 +468.9 468919 3.6 FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 FOS DEK ZC3H11A ANGPTL4 HNRNPM ZNF317 XAB2 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF559 ZNF414
GH19I008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 38.2 +439.5 439484 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 ENSG00000269300 MAP2K7 MARCH2
GH19I008524 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 55.4 +306.2 306189 2.4 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF266 ZNF559 XAB2 ZNF414 ENSG00000269300
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF558 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF558 gene promoter:

Genomic Locations for ZNF558 Gene

Genomic Locations for ZNF558 Gene
26,159 bases
Minus strand

Genomic View for ZNF558 Gene

Genes around ZNF558 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF558 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF558 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF558 Gene

Proteins for ZNF558 Gene

  • Protein details for ZNF558 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 558
    Protein Accession:
    Secondary Accessions:
    • A8K5F0
    • B7Z798

    Protein attributes for ZNF558 Gene

    402 amino acids
    Molecular mass:
    45755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF558 Gene


neXtProt entry for ZNF558 Gene

Post-translational modifications for ZNF558 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF558 Gene

No data available for DME Specific Peptides for ZNF558 Gene

Domains & Families for ZNF558 Gene

Gene Families for ZNF558 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF558 Gene

Suggested Antigen Peptide Sequences for ZNF558 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF558: view

Function for ZNF558 Gene

Molecular function for ZNF558 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF558 Gene

Gene Ontology (GO) - Molecular Function for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF558: view

Phenotypes for ZNF558 Gene

GenomeRNAi human phenotypes for ZNF558:
genes like me logo Genes that share phenotypes with ZNF558: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF558 Gene

Localization for ZNF558 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF558 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF558 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF558: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF558 Gene

Pathways & Interactions for ZNF558 Gene

SuperPathways for ZNF558 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF558: view

Pathways by source for ZNF558 Gene

2 Reactome pathways for ZNF558 Gene

Gene Ontology (GO) - Biological Process for ZNF558 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF558: view

No data available for SIGNOR curated interactions for ZNF558 Gene

Drugs & Compounds for ZNF558 Gene

No Compound Related Data Available

Transcripts for ZNF558 Gene

Unigene Clusters for ZNF558 Gene

Zinc finger protein 558:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF558 Gene

No ASD Table

Relevant External Links for ZNF558 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF558 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF558 Gene

Protein differential expression in normal tissues from HIPED for ZNF558 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF558 Gene

Protein tissue co-expression partners for ZNF558 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF558 Gene:


SOURCE GeneReport for Unigene cluster for ZNF558 Gene:


Evidence on tissue expression from TISSUES for ZNF558 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF558: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF558 Gene

Orthologs for ZNF558 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF558 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF558 33 34
  • 98.92 (n)
(Canis familiaris)
Mammalia ZNF558 33 34
  • 86.73 (n)
(Bos Taurus)
Mammalia ZNF558 34
  • 86 (a)
(Mus musculus)
Mammalia Zfp558 33 16 34
  • 82.26 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
-- 34
  • 48 (a)
-- 34
  • 47 (a)
-- 34
  • 38 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
(Danio rerio)
Actinopterygii ZNF557 34
  • 20 (a)
Species where no ortholog for ZNF558 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF558 Gene

Gene Tree for ZNF558 (if available)
Gene Tree for ZNF558 (if available)

Paralogs for ZNF558 Gene

Paralogs for ZNF558 Gene

(535) SIMAP similar genes for ZNF558 Gene using alignment to 2 proteins: Pseudogenes for ZNF558 Gene

genes like me logo Genes that share paralogs with ZNF558: view

Variants for ZNF558 Gene

Sequence variations from dbSNP and Humsavar for ZNF558 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000262306 -- 8,821,049(-) G/T intron_variant
rs1000263113 -- 8,823,228(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000326254 -- 8,828,063(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000459045 -- 8,833,546(-) TCTCT/TCT upstream_transcript_variant
rs1000726641 -- 8,830,994(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF558 Gene

Variant ID Type Subtype PubMed ID
dgv48n68 CNV gain 17160897
esv2758744 CNV gain+loss 17122850
esv2762024 CNV gain 21179565
nsv1059126 CNV gain 25217958
nsv171 CNV deletion 15895083
nsv2402 CNV deletion 18451855
nsv428362 CNV gain+loss 18775914
nsv469648 CNV gain+loss 16826518
nsv483078 CNV gain+loss 15286789
nsv833738 CNV gain 17160897
nsv833739 CNV gain+loss 17160897

Variation tolerance for ZNF558 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF558 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF558 Gene

Disorders for ZNF558 Gene

Additional Disease Information for ZNF558

No disorders were found for ZNF558 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF558 Gene

Publications for ZNF558 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58

Products for ZNF558 Gene

Sources for ZNF558 Gene

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