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Aliases for ZNF557 Gene

Aliases for ZNF557 Gene

  • Zinc Finger Protein 557 2 3 4 5
  • CTB-25J19.9 3

External Ids for ZNF557 Gene

Previous GeneCards Identifiers for ZNF557 Gene

  • GC19P007021
  • GC19P007022
  • GC19P006803

Summaries for ZNF557 Gene

GeneCards Summary for ZNF557 Gene

ZNF557 (Zinc Finger Protein 557) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF557 Gene

Additional gene information for ZNF557 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF557 Gene

Genomics for ZNF557 Gene

GeneHancer (GH) Regulatory Elements for ZNF557 Gene

Promoters and enhancers for ZNF557 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007068 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.4 396 2.3 SP1 ZFX ELF3 NKRF POLR2A ZNF687 ZBTB7A SP7 TRIM24 ELF1 ZNF557 GC19P007068 MBD3L3 TRIP10 XAB2 PIR45596
GH19J006527 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 163.4 -538.6 -538575 6.6 ZNF473 SP1 ELF3 CC2D1A ZFX ZNF148 NKRF POLR2A MLLT1 GTF2F1 TNFSF9 ZNF557 KHSRP DUS3L SAFB SAFB2 SNRPEP4 RANBP3 GTF2F1 ENSG00000267571
GH19J006718 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 104.2 -348.5 -348513 6.8 ZNF652 CC2D1A SP1 ELF3 POLR2A MLLT1 CEBPG RERE GTF2F1 CSDE1 C3 XAB2 ZNF557 DUS3L KHSRP ENSG00000267571 RANBP3 VMAC GPR108 TRIP10
GH19J006270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 86.4 -793.9 -793947 11 HDGF ZFX SP1 CTCF CC2D1A ELF3 MNT CBFA2T2 ZNF148 MLLT1 MLLT1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC RANBP3 GPR108
GH19J007177 Enhancer 1.3 Ensembl ENCODE dbSUPER 78.5 +111.6 111615 7.1 ZNF473 NKRF ZNF121 CEBPG ZNF687 RELA CREM MLLT1 ZNF404 ZNF560 ELAVL1 XAB2 KHSRP ZNF557 MAP2K7 GTF2F1 DENND1C ARHGEF18 GPR108 EVI5L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF557 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF557 gene promoter:
  • Bach1
  • HTF
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for ZNF557 Gene

Genomic Locations for ZNF557 Gene
chr19:7,069,460-7,087,968
(GRCh38/hg38)
Size:
18,509 bases
Orientation:
Plus strand
chr19:7,069,455-7,087,979
(GRCh37/hg19)
Size:
18,525 bases
Orientation:
Plus strand

Genomic View for ZNF557 Gene

Genes around ZNF557 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF557 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF557 Gene

Proteins for ZNF557 Gene

  • Protein details for ZNF557 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N988-ZN557_HUMAN
    Recommended name:
    Zinc finger protein 557
    Protein Accession:
    Q8N988
    Secondary Accessions:
    • Q6PEJ3
    • Q9BTZ1

    Protein attributes for ZNF557 Gene

    Size:
    423 amino acids
    Molecular mass:
    48627 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04567.1; Type=Frameshift; Positions=23; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF557 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF557 Gene

Post-translational modifications for ZNF557 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF557 Gene

No data available for DME Specific Peptides for ZNF557 Gene

Domains & Families for ZNF557 Gene

Gene Families for ZNF557 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF557 Gene

Suggested Antigen Peptide Sequences for ZNF557 Gene

GenScript: Design optimal peptide antigens:
  • ZNF557 protein (Q4G137_HUMAN)
  • Zinc finger protein 557 (ZN557_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N988

UniProtKB/Swiss-Prot:

ZN557_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF557: view

Function for ZNF557 Gene

Molecular function for ZNF557 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF557 Gene

Gene Ontology (GO) - Molecular Function for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF557: view
genes like me logo Genes that share phenotypes with ZNF557: view

Animal Model Products

CRISPR Products

miRNA for ZNF557 Gene

miRTarBase miRNAs that target ZNF557

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF557 - Now 50% OFF >
  • * ZNF557 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF557 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF557 Gene

Localization for ZNF557 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF557 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF557 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF557: view

Pathways & Interactions for ZNF557 Gene

genes like me logo Genes that share pathways with ZNF557: view

Pathways by source for ZNF557 Gene

2 Reactome pathways for ZNF557 Gene
1 KEGG pathway for ZNF557 Gene

Gene Ontology (GO) - Biological Process for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF557: view

No data available for SIGNOR curated interactions for ZNF557 Gene

Drugs & Compounds for ZNF557 Gene

No Compound Related Data Available

Transcripts for ZNF557 Gene

mRNA/cDNA for ZNF557 Gene

Unigene Clusters for ZNF557 Gene

Zinc finger protein 557:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF557 - Now 50% OFF >
  • * ZNF557 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF557 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: -

Relevant External Links for ZNF557 Gene

GeneLoc Exon Structure for
ZNF557
ECgene alternative splicing isoforms for
ZNF557

Expression for ZNF557 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF557 Gene

Protein differential expression in normal tissues from HIPED for ZNF557 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF557 Gene



Protein tissue co-expression partners for ZNF557 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF557 Gene:

ZNF557

SOURCE GeneReport for Unigene cluster for ZNF557 Gene:

Hs.591380

Evidence on tissue expression from TISSUES for ZNF557 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF557: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF557 Gene

Orthologs for ZNF557 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF557 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF557 35 34
  • 98.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm14393 35
  • 43 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 35
  • 19 (a)
OneToMany
Species where no ortholog for ZNF557 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF557 Gene

ENSEMBL:
Gene Tree for ZNF557 (if available)
TreeFam:
Gene Tree for ZNF557 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF557: view image

Paralogs for ZNF557 Gene

(484) SIMAP similar genes for ZNF557 Gene using alignment to 2 proteins:

  • ZN557_HUMAN
  • Q4G137_HUMAN
genes like me logo Genes that share paralogs with ZNF557: view

Variants for ZNF557 Gene

Sequence variations from dbSNP and Humsavar for ZNF557 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000324555 -- 7,074,094(+) A/G intron_variant
rs1000374614 -- 7,079,703(+) G/A intron_variant
rs1000605260 -- 7,074,387(+) A/G intron_variant
rs1000655743 -- 7,085,780(+) C/A/G 3_prime_UTR_variant
rs1000773911 -- 7,068,737(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF557 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6245n54 CNV gain 21841781
esv2718082 CNV deletion 23290073
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3574297 CNV gain 25503493
esv3643577 CNV gain 21293372
nsv1056752 CNV gain 25217958
nsv1061916 CNV gain 25217958
nsv517794 CNV gain+loss 19592680
nsv578500 CNV gain 21841781

Variation tolerance for ZNF557 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF557 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF557

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF557 Gene

Disorders for ZNF557 Gene

Additional Disease Information for ZNF557

No disorders were found for ZNF557 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF557 Gene

Publications for ZNF557 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58

Products for ZNF557 Gene

Sources for ZNF557 Gene

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