Aliases for ZNF557 Gene

Aliases for ZNF557 Gene

  • Zinc Finger Protein 557 2 3 4 5
  • CTB-25J19.9 3
  • MGC4054 2
  • ZNF557 5

External Ids for ZNF557 Gene

Previous GeneCards Identifiers for ZNF557 Gene

  • GC19P007021
  • GC19P007022
  • GC19P006803

Summaries for ZNF557 Gene

GeneCards Summary for ZNF557 Gene

ZNF557 (Zinc Finger Protein 557) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot Summary for ZNF557 Gene

Additional gene information for ZNF557 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF557 Gene

Genomics for ZNF557 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF557 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF557 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF557

Top Transcription factor binding sites by QIAGEN in the ZNF557 gene promoter:
  • Bach1
  • HTF
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for ZNF557 Gene

Genomic Locations for ZNF557 Gene
18,266 bases
Plus strand
18,525 bases
Plus strand

Genomic View for ZNF557 Gene

Genes around ZNF557 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF557 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF557 Gene

Proteins for ZNF557 Gene

  • Protein details for ZNF557 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 557
    Protein Accession:
    Secondary Accessions:
    • Q6PEJ3
    • Q9BTZ1

    Protein attributes for ZNF557 Gene

    423 amino acids
    Molecular mass:
    48627 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04567.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF557 Gene


neXtProt entry for ZNF557 Gene

Post-translational modifications for ZNF557 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF557 Gene

No data available for DME Specific Peptides for ZNF557 Gene

Domains & Families for ZNF557 Gene

Gene Families for ZNF557 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF557 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF557 Gene

GenScript: Design optimal peptide antigens:
  • ZNF557 protein (Q4G137_HUMAN)
  • Zinc finger protein 557 (ZN557_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF557: view

Function for ZNF557 Gene

Molecular function for ZNF557 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF557 Gene

Gene Ontology (GO) - Molecular Function for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF557: view
genes like me logo Genes that share phenotypes with ZNF557: view

Animal Model Products

CRISPR Products

miRNA for ZNF557 Gene

miRTarBase miRNAs that target ZNF557

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF557

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF557 Gene

Localization for ZNF557 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF557 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF557 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF557: view

Pathways & Interactions for ZNF557 Gene

genes like me logo Genes that share pathways with ZNF557: view

Pathways by source for ZNF557 Gene

2 Reactome pathways for ZNF557 Gene
1 KEGG pathway for ZNF557 Gene

Gene Ontology (GO) - Biological Process for ZNF557 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF557: view

No data available for SIGNOR curated interactions for ZNF557 Gene

Drugs & Compounds for ZNF557 Gene

No Compound Related Data Available

Transcripts for ZNF557 Gene

mRNA/cDNA for ZNF557 Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF557

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF557 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: -

Relevant External Links for ZNF557 Gene

GeneLoc Exon Structure for

Expression for ZNF557 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF557 Gene

Protein differential expression in normal tissues from HIPED for ZNF557 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF557 Gene

Protein tissue co-expression partners for ZNF557 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF557

SOURCE GeneReport for Unigene cluster for ZNF557 Gene:


Evidence on tissue expression from TISSUES for ZNF557 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF557: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF557 Gene

Orthologs for ZNF557 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF557 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF557 30 31
  • 98.98 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 56 (a)
-- 31
  • 51 (a)
-- 31
  • 44 (a)
-- 31
  • 41 (a)
-- 31
  • 36 (a)
-- 31
  • 34 (a)
(Mus musculus)
Mammalia Gm14393 31
  • 43 (a)
(Bos Taurus)
Mammalia -- 31
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
(Danio rerio)
Actinopterygii ZNF557 31
  • 19 (a)
Species where no ortholog for ZNF557 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF557 Gene

Gene Tree for ZNF557 (if available)
Gene Tree for ZNF557 (if available)
Evolutionary constrained regions (ECRs) for ZNF557: view image

Paralogs for ZNF557 Gene

(484) SIMAP similar genes for ZNF557 Gene using alignment to 2 proteins:

  • ZN557_HUMAN
  • Q4G137_HUMAN
genes like me logo Genes that share paralogs with ZNF557: view

Variants for ZNF557 Gene

Additional dbSNP identifiers (rs#s) for ZNF557 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF557 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6245n54 CNV gain 21841781
esv2718082 CNV deletion 23290073
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3574297 CNV gain 25503493
esv3643577 CNV gain 21293372
nsv1056752 CNV gain 25217958
nsv1061916 CNV gain 25217958
nsv517794 CNV gain+loss 19592680
nsv578500 CNV gain 21841781

Variation tolerance for ZNF557 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF557 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF557 Gene

Disorders for ZNF557 Gene

No disorders were found for ZNF557 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF557 Gene

Publications for ZNF557 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3

Products for ZNF557 Gene

Sources for ZNF557 Gene