Aliases for ZNF556 Gene

Aliases for ZNF556 Gene

  • Zinc Finger Protein 556 2 3 4 5

External Ids for ZNF556 Gene

Previous GeneCards Identifiers for ZNF556 Gene

  • GC19P002819
  • GC19P002820
  • GC19P002638

Summaries for ZNF556 Gene

GeneCards Summary for ZNF556 Gene

ZNF556 (Zinc Finger Protein 556) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP90.

UniProtKB/Swiss-Prot Summary for ZNF556 Gene

Additional gene information for ZNF556 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF556 Gene

Genomics for ZNF556 Gene

GeneHancer (GH) Regulatory Elements for ZNF556 Gene

Promoters and enhancers for ZNF556 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF556 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF556 gene promoter:
  • ATF6
  • C/EBPalpha
  • HTF
  • LCR-F1
  • YY1

Genomic Locations for ZNF556 Gene

Genomic Locations for ZNF556 Gene
16,111 bases
Plus strand
11,183 bases
Plus strand

Genomic View for ZNF556 Gene

Genes around ZNF556 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF556 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF556 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF556 Gene

Proteins for ZNF556 Gene

  • Protein details for ZNF556 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 556
    Protein Accession:
    Secondary Accessions:
    • Q96GM3

    Protein attributes for ZNF556 Gene

    456 amino acids
    Molecular mass:
    51581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF556 Gene

Post-translational modifications for ZNF556 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF556 Gene

No data available for DME Specific Peptides for ZNF556 Gene

Domains & Families for ZNF556 Gene

Gene Families for ZNF556 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF556 Gene

Suggested Antigen Peptide Sequences for ZNF556 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 556 (ZN556_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF556: view

Function for ZNF556 Gene

Molecular function for ZNF556 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF556 Gene

Gene Ontology (GO) - Molecular Function for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF556: view
genes like me logo Genes that share phenotypes with ZNF556: view

Animal Model Products

CRISPR Products

miRNA for ZNF556 Gene

miRTarBase miRNAs that target ZNF556

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF556 Gene

Localization for ZNF556 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF556 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF556 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF556: view

Pathways & Interactions for ZNF556 Gene

genes like me logo Genes that share pathways with ZNF556: view

Pathways by source for ZNF556 Gene

2 Reactome pathways for ZNF556 Gene
1 KEGG pathway for ZNF556 Gene

Gene Ontology (GO) - Biological Process for ZNF556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF556: view

No data available for SIGNOR curated interactions for ZNF556 Gene

Drugs & Compounds for ZNF556 Gene

No Compound Related Data Available

Transcripts for ZNF556 Gene

mRNA/cDNA for ZNF556 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF556 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c

Relevant External Links for ZNF556 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF556 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF556 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF556 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.2), Ovary (x7.7), Brain - Cerebellum (x7.4), and Muscle - Skeletal (x5.3).

Protein differential expression in normal tissues from HIPED for ZNF556 Gene

This gene is overexpressed in Bone (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF556 Gene

Protein tissue co-expression partners for ZNF556 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF556 Gene:


SOURCE GeneReport for Unigene cluster for ZNF556 Gene:


Evidence on tissue expression from TISSUES for ZNF556 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF556: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF556 Gene

Orthologs for ZNF556 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF556 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF556 33 32
  • 99.12 (n)
(Canis familiaris)
Mammalia ZNF556 33 32
  • 78.23 (n)
(Mus musculus)
Mammalia C330013J21Rik 33
  • 36 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 34 (a)
-- 33
  • 31 (a)
-- 33
  • 31 (a)
-- 33
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 25 (a)
(Danio rerio)
Actinopterygii CT573234.2 33
  • 25 (a)
CR388132.2 33
  • 25 (a)
Species where no ortholog for ZNF556 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF556 Gene

Gene Tree for ZNF556 (if available)
Gene Tree for ZNF556 (if available)
Evolutionary constrained regions (ECRs) for ZNF556: view image

Paralogs for ZNF556 Gene

(422) SIMAP similar genes for ZNF556 Gene using alignment to 2 proteins:

  • ZN556_HUMAN
genes like me logo Genes that share paralogs with ZNF556: view

Variants for ZNF556 Gene

Sequence variations from dbSNP and Humsavar for ZNF556 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000000942 -- 2,879,028(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000295290 -- 2,866,388(+) G/C upstream_transcript_variant
rs1000433434 -- 2,873,749(+) T/C intron_variant
rs1000786223 -- 2,870,375(+) C/A intron_variant
rs1000925244 -- 2,870,186(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF556 Gene

Variant ID Type Subtype PubMed ID
nsv1063039 CNV loss 25217958
nsv509715 CNV insertion 20534489

Variation tolerance for ZNF556 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF556 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF556 Gene

Disorders for ZNF556 Gene

Additional Disease Information for ZNF556

No disorders were found for ZNF556 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF556 Gene

Publications for ZNF556 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for ZNF556 Gene

Sources for ZNF556 Gene