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Aliases for ZNF555 Gene

Aliases for ZNF555 Gene

  • Zinc Finger Protein 555 2 3 4 5

External Ids for ZNF555 Gene

Previous GeneCards Identifiers for ZNF555 Gene

  • GC19P002793
  • GC19P002794
  • GC19P002612

Summaries for ZNF555 Gene

GeneCards Summary for ZNF555 Gene

ZNF555 (Zinc Finger Protein 555) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF77.

UniProtKB/Swiss-Prot for ZNF555 Gene

Additional gene information for ZNF555 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF555 Gene

Genomics for ZNF555 Gene

GeneHancer (GH) Regulatory Elements for ZNF555 Gene

Promoters and enhancers for ZNF555 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002840 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 624.5 +0.4 366 3.2 MTA3 ZFX SP1 ZNF148 NKRF ZSCAN21 FOS AHR MAFK TFE3 ZNF555 SF3A2 ZNF77 CACTIN-AS1 CACTIN DOT1L SPPL2B LMNB2 APBA3 ZNF556
GH19J002839 Enhancer 0.6 ENCODE 600.7 -1.7 -1677 0.2 CEBPG ZNF384 CEBPA GATAD2A FOXK2 FOXA2 FOXP1 CEBPB NFIL3 ZBTB33 ZNF555 GC19P002827 GC19P002822
GH19J003604 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 41 +765.8 765820 5.3 ZNF473 HDGF ZFX CBFA2T2 ZNF148 NKRF MLLT1 GTF2F1 NCOA3 CDC5L CACTIN-AS1 TBXA2R ZNF77 CACTIN ENSG00000267030 ZNF555 ENSG00000267769 YJU2 APBA3 GNA11
GH19J002038 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.8 -790.4 -790410 24.2 HDGF SP1 ZFX CC2D1A ELF3 CTCF ZKSCAN8 MNT ZNF148 NKRF MKNK2 ZNF77 SF3A2 DAZAP1 CIRBP TCF3 ZNF555 LMNB2 LOC100288123 PWWP3A
GH19J003150 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +312.0 311953 6 ZNF473 SP1 CC2D1A ZFX CBFA2T2 ZNF148 GTF2F1 ZNF687 CDC5L BACH1 LOC100996351 GC19P003153 GC19P003154 PIR47090 ZNF77 CACTIN GNA11 DOT1L ZNF555 LMNB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF555 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF555 gene promoter:
  • AP-1
  • HTF
  • p300

Genomic Locations for ZNF555 Gene

Genomic Locations for ZNF555 Gene
chr19:2,841,435-2,860,474
(GRCh38/hg38)
Size:
19,040 bases
Orientation:
Plus strand
chr19:2,841,433-2,860,482
(GRCh37/hg19)
Size:
19,050 bases
Orientation:
Plus strand

Genomic View for ZNF555 Gene

Genes around ZNF555 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF555 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF555 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF555 Gene

Proteins for ZNF555 Gene

  • Protein details for ZNF555 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEP9-ZN555_HUMAN
    Recommended name:
    Zinc finger protein 555
    Protein Accession:
    Q8NEP9
    Secondary Accessions:
    • A8KA89
    • K7EQM2
    • Q8NA46
    • Q96MP1

    Protein attributes for ZNF555 Gene

    Size:
    628 amino acids
    Molecular mass:
    73084 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF555 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF555 Gene

Post-translational modifications for ZNF555 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF555 Gene

No data available for DME Specific Peptides for ZNF555 Gene

Domains & Families for ZNF555 Gene

Gene Families for ZNF555 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF555 Gene

Suggested Antigen Peptide Sequences for ZNF555 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 555 (ZN555_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEP9

UniProtKB/Swiss-Prot:

ZN555_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF555: view

Function for ZNF555 Gene

Molecular function for ZNF555 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF555 Gene

Gene Ontology (GO) - Molecular Function for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF555: view
genes like me logo Genes that share phenotypes with ZNF555: view

Animal Model Products

CRISPR Products

miRNA for ZNF555 Gene

miRTarBase miRNAs that target ZNF555

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF555 - Now 50% OFF >
  • * ZNF555 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF555 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF555 Gene

Localization for ZNF555 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF555 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF555 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF555: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF555 Gene

Pathways & Interactions for ZNF555 Gene

genes like me logo Genes that share pathways with ZNF555: view

Pathways by source for ZNF555 Gene

2 Reactome pathways for ZNF555 Gene
1 KEGG pathway for ZNF555 Gene

Gene Ontology (GO) - Biological Process for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF555: view

No data available for SIGNOR curated interactions for ZNF555 Gene

Drugs & Compounds for ZNF555 Gene

No Compound Related Data Available

Transcripts for ZNF555 Gene

mRNA/cDNA for ZNF555 Gene

Unigene Clusters for ZNF555 Gene

Zinc finger protein 555:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF555 - Now 50% OFF >
  • * ZNF555 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF555 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF555 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3:

Relevant External Links for ZNF555 Gene

GeneLoc Exon Structure for
ZNF555
ECgene alternative splicing isoforms for
ZNF555

Expression for ZNF555 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF555 Gene

Protein differential expression in normal tissues from HIPED for ZNF555 Gene

This gene is overexpressed in Synovial fluid (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF555 Gene



Protein tissue co-expression partners for ZNF555 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF555 Gene:

ZNF555

SOURCE GeneReport for Unigene cluster for ZNF555 Gene:

Hs.47712

Evidence on tissue expression from TISSUES for ZNF555 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF555: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF555 Gene

Orthologs for ZNF555 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF555 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF555 35 34
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF555 35 34
  • 85.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF555 35 34
  • 85.36 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm14391 35
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR388132.2 35
  • 42 (a)
ManyToMany
CT573234.2 35
  • 42 (a)
ManyToMany
Species where no ortholog for ZNF555 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF555 Gene

ENSEMBL:
Gene Tree for ZNF555 (if available)
TreeFam:
Gene Tree for ZNF555 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF555: view image

Paralogs for ZNF555 Gene

(481) SIMAP similar genes for ZNF555 Gene using alignment to 2 proteins:

  • ZN555_HUMAN
  • K7ENK0_HUMAN

Pseudogenes.org Pseudogenes for ZNF555 Gene

genes like me logo Genes that share paralogs with ZNF555: view

Variants for ZNF555 Gene

Sequence variations from dbSNP and Humsavar for ZNF555 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000217973 -- 2,849,236(+) C/T intron_variant
rs1000291602 -- 2,849,025(+) G/C intron_variant
rs1000318270 -- 2,843,256(+) T/G intron_variant
rs1000387075 -- 2,856,166(+) T/C 3_prime_UTR_variant
rs1000464593 -- 2,844,310(+) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF555 Gene

Variant ID Type Subtype PubMed ID
dgv6226n54 CNV loss 21841781
esv2670441 CNV deletion 23128226
esv27111 CNV loss 19812545
nsv1143407 CNV deletion 24896259
nsv482209 CNV loss 20164927
nsv509715 CNV insertion 20534489
nsv528638 CNV gain 19592680

Variation tolerance for ZNF555 Gene

Residual Variation Intolerance Score: 8.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF555 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF555

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF555 Gene

Disorders for ZNF555 Gene

Additional Disease Information for ZNF555

No disorders were found for ZNF555 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF555 Gene

Publications for ZNF555 Gene

  1. ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy. (PMID: 26184877) Kim E … Pirozhkova I (Nucleic acids research 2015) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF555 Gene

Sources for ZNF555 Gene

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