Aliases for ZNF555 Gene

Aliases for ZNF555 Gene

  • Zinc Finger Protein 555 2 3 4 5

External Ids for ZNF555 Gene

Previous GeneCards Identifiers for ZNF555 Gene

  • GC19P002793
  • GC19P002794
  • GC19P002612

Summaries for ZNF555 Gene

GeneCards Summary for ZNF555 Gene

ZNF555 (Zinc Finger Protein 555) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF20.

UniProtKB/Swiss-Prot Summary for ZNF555 Gene

Additional gene information for ZNF555 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF555 Gene

Genomics for ZNF555 Gene

GeneHancer (GH) Regulatory Elements for ZNF555 Gene

Promoters and enhancers for ZNF555 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002840 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 507.2 +0.4 366 3.2 EP300 CTCF NRF1 POLR2G SP1 PHF8 JUND FOS ZNF639 ZIC2 ZNF555 ZNF77 SF3A2 CACTIN GNA11 ZNF556 ZNF57 ENSG00000253392 SCAMP4 CSNK1G2
GH19J002839 Enhancer 0.6 ENCODE 500.7 -1.7 -1677 0.2 FOXK2 NCOR1 SKI FOXA2 CEBPB CEBPG SPI1 FOXP1 ZBTB33 NFIL3 ZNF555 piR-48389-011
GH19J003604 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 41 +765.8 765820 5.3 NRF1 ZNF300 GTF2E2 ZIC2 ZNF423 ZBTB26 TARDBP KLF4 DNMT1 KLF7 CACTIN-AS1 TBXA2R ZNF77 CACTIN ZNF555 ENSG00000267030 YJU2 GNA11 ZNF554 HDGFL2
GH19J003150 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +312.0 311953 6 NRF1 TCF12 SP1 GTF2E2 JUND FOS ZNF639 REST ZBTB10 ZNF263 LOC100996351 ZNF77 CACTIN GNA11 ZNF555 SPPL2B AP3D1 GNA15 TLE2 LMNB2
GH19J002079 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.1 -752.5 -752527 19 RXRA EP300 HNRNPK ZBTB40 CTCF ZSCAN5C SIN3A NRF1 POLR2G SP1 MOB3A IZUMO4 SF3A2 CIRBP ZNF77 LOC100288123 BTBD2 DAZAP1 ZNF555 TCF3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF555 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF555

Top Transcription factor binding sites by QIAGEN in the ZNF555 gene promoter:
  • AP-1
  • HTF
  • p300

Genomic Locations for ZNF555 Gene

Genomic Locations for ZNF555 Gene
19,040 bases
Plus strand
19,050 bases
Plus strand

Genomic View for ZNF555 Gene

Genes around ZNF555 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF555 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF555 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF555 Gene

Proteins for ZNF555 Gene

  • Protein details for ZNF555 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 555
    Protein Accession:
    Secondary Accessions:
    • A8KA89
    • K7EQM2
    • Q8NA46
    • Q96MP1

    Protein attributes for ZNF555 Gene

    628 amino acids
    Molecular mass:
    73084 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF555 Gene


neXtProt entry for ZNF555 Gene

Post-translational modifications for ZNF555 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF555 Gene

No data available for DME Specific Peptides for ZNF555 Gene

Domains & Families for ZNF555 Gene

Gene Families for ZNF555 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF555 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF555 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 555 (ZN555_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF555: view

Function for ZNF555 Gene

Molecular function for ZNF555 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF555 Gene

Gene Ontology (GO) - Molecular Function for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF555: view
genes like me logo Genes that share phenotypes with ZNF555: view

Animal Model Products

miRNA for ZNF555 Gene

miRTarBase miRNAs that target ZNF555

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF555 Gene

Localization for ZNF555 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF555 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF555 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF555: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF555 Gene

Pathways & Interactions for ZNF555 Gene

genes like me logo Genes that share pathways with ZNF555: view

Pathways by source for ZNF555 Gene

2 Reactome pathways for ZNF555 Gene
1 KEGG pathway for ZNF555 Gene

Gene Ontology (GO) - Biological Process for ZNF555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF555: view

No data available for SIGNOR curated interactions for ZNF555 Gene

Drugs & Compounds for ZNF555 Gene

No Compound Related Data Available

Transcripts for ZNF555 Gene

mRNA/cDNA for ZNF555 Gene

8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF555 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP2: -

Relevant External Links for ZNF555 Gene

GeneLoc Exon Structure for

Expression for ZNF555 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF555 Gene

Protein differential expression in normal tissues from HIPED for ZNF555 Gene

This gene is overexpressed in Synovial fluid (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF555 Gene

Protein tissue co-expression partners for ZNF555 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF555

SOURCE GeneReport for Unigene cluster for ZNF555 Gene:


Evidence on tissue expression from TISSUES for ZNF555 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF555: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF555 Gene

Orthologs for ZNF555 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF555 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF555 31 30
  • 99.15 (n)
(Canis familiaris)
Mammalia ZNF555 31 30
  • 85.81 (n)
(Bos Taurus)
Mammalia ZNF555 31 30
  • 85.36 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
-- 31
  • 49 (a)
-- 31
  • 47 (a)
-- 31
  • 45 (a)
(Mus musculus)
Mammalia Gm14391 31
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
(Danio rerio)
Actinopterygii CR388132.2 31
  • 42 (a)
CT573234.2 31
  • 42 (a)
Species where no ortholog for ZNF555 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF555 Gene

Gene Tree for ZNF555 (if available)
Gene Tree for ZNF555 (if available)
Evolutionary constrained regions (ECRs) for ZNF555: view image

Paralogs for ZNF555 Gene

(481) SIMAP similar genes for ZNF555 Gene using alignment to 2 proteins:

  • ZN555_HUMAN
  • K7ENK0_HUMAN Pseudogenes for ZNF555 Gene

genes like me logo Genes that share paralogs with ZNF555: view

Variants for ZNF555 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF555 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17851955 - p.His194Asn
rs17856648 - p.Lys515Thr
rs17856649 - p.Asn107Asp
rs36012545 - p.Pro137Leu

Additional dbSNP identifiers (rs#s) for ZNF555 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF555 Gene

Variant ID Type Subtype PubMed ID
dgv6226n54 CNV loss 21841781
esv2670441 CNV deletion 23128226
esv27111 CNV loss 19812545
nsv1143407 CNV deletion 24896259
nsv482209 CNV loss 20164927
nsv509715 CNV insertion 20534489
nsv528638 CNV gain 19592680

Variation tolerance for ZNF555 Gene

Residual Variation Intolerance Score: 8.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF555 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF555 Gene

Disorders for ZNF555 Gene

Additional Disease Information for ZNF555

No disorders were found for ZNF555 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF555 Gene

Publications for ZNF555 Gene

  1. ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophy. (PMID: 26184877) Kim E … Pirozhkova I (Nucleic acids research 2015) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for ZNF555 Gene

Sources for ZNF555 Gene