Aliases for ZNF554 Gene

Aliases for ZNF554 Gene

  • Zinc Finger Protein 554 2 3 4 5

External Ids for ZNF554 Gene

Previous GeneCards Identifiers for ZNF554 Gene

  • GC19P002771
  • GC19P002772
  • GC19P002591

Summaries for ZNF554 Gene

GeneCards Summary for ZNF554 Gene

ZNF554 (Zinc Finger Protein 554) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP90.

UniProtKB/Swiss-Prot Summary for ZNF554 Gene

Additional gene information for ZNF554 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF554 Gene

Genomics for ZNF554 Gene

GeneHancer (GH) Regulatory Elements for ZNF554 Gene

Promoters and enhancers for ZNF554 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002817 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 531.2 -0.6 -567 4.2 ZNF217 EP300 CTCF TCF12 NRF1 MYC POLR2G USF1 SP1 SIX5 ZNF554 piR-50437-320 ZNF77 CACTIN CACTIN-AS1 SF3A2 THOP1 APBA3 SPPL2B ZNF556
GH19J002782 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.3 -35.7 -35667 5.6 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 POLR2G THOP1 SGTA lnc-SLC39A3-3 ZNF554
GH19J003604 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 23.7 +787.4 787387 5.3 NRF1 ZNF300 GTF2E2 ZIC2 ZNF423 ZBTB26 TARDBP KLF4 DNMT1 KLF7 CACTIN-AS1 TBXA2R ZNF77 CACTIN ZNF555 ENSG00000267030 YJU2 GNA11 ZNF554 HDGFL2
GH19J002461 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.5 -357.5 -357472 2.8 EP300 ZNF217 SIN3A TCF12 USF1 POLR2G TEAD4 CTCF ZNF639 ZNF10 LINC01775 SF3A2 TCF3 LOC100288123 GNA11 ZNF555 ZNF554 TLE2 ZNF77 TIMM13
GH19J002160 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 -652.1 -652128 13.7 EP300 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G SP1 NCOR1 DOT1L ZNF77 AP3D1 GADD45B CIRBP ENSG00000267283 SF3A2 LOC100288123 ZNF554 DAZAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF554 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF554

Top Transcription factor binding sites by QIAGEN in the ZNF554 gene promoter:
  • HTF
  • p300
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ZNF554 Gene

Genomic Locations for ZNF554 Gene
16,868 bases
Plus strand
16,862 bases
Plus strand

Genomic View for ZNF554 Gene

Genes around ZNF554 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF554 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF554 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF554 Gene

Proteins for ZNF554 Gene

  • Protein details for ZNF554 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 554
    Protein Accession:
    Secondary Accessions:
    • Q8NAT3
    • Q9BWN3

    Protein attributes for ZNF554 Gene

    538 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF554 Gene

Post-translational modifications for ZNF554 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF554 Gene

Domains & Families for ZNF554 Gene

Gene Families for ZNF554 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF554 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF554 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 554 (ZN554_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF554: view

Function for ZNF554 Gene

Molecular function for ZNF554 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF554 Gene

Gene Ontology (GO) - Molecular Function for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF554: view
genes like me logo Genes that share phenotypes with ZNF554: view

Animal Model Products

miRNA for ZNF554 Gene

miRTarBase miRNAs that target ZNF554

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF554 Gene

Localization for ZNF554 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF554 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF554 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF554: view

Pathways & Interactions for ZNF554 Gene

genes like me logo Genes that share pathways with ZNF554: view

Pathways by source for ZNF554 Gene

2 Reactome pathways for ZNF554 Gene
1 KEGG pathway for ZNF554 Gene

Interacting Proteins for ZNF554 Gene


Gene Ontology (GO) - Biological Process for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF554: view

No data available for SIGNOR curated interactions for ZNF554 Gene

Drugs & Compounds for ZNF554 Gene

No Compound Related Data Available

Transcripts for ZNF554 Gene

mRNA/cDNA for ZNF554 Gene

7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF554 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for ZNF554 Gene

GeneLoc Exon Structure for

Expression for ZNF554 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF554 Gene

Protein differential expression in normal tissues from HIPED for ZNF554 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF554 Gene

Protein tissue co-expression partners for ZNF554 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF554

SOURCE GeneReport for Unigene cluster for ZNF554 Gene:


Evidence on tissue expression from TISSUES for ZNF554 Gene

  • Eye(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF554: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF554 Gene

Orthologs for ZNF554 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF554 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF554 31 30
  • 98.76 (n)
(Canis familiaris)
Mammalia ZNF554 31 30
  • 79.06 (n)
(Bos Taurus)
Mammalia ZNF554 31 30
  • 78.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 31
  • 20 (a)
Species where no ortholog for ZNF554 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF554 Gene

Gene Tree for ZNF554 (if available)
Gene Tree for ZNF554 (if available)
Evolutionary constrained regions (ECRs) for ZNF554: view image

Paralogs for ZNF554 Gene

(505) SIMAP similar genes for ZNF554 Gene using alignment to 3 proteins:

  • ZN554_HUMAN
genes like me logo Genes that share paralogs with ZNF554: view

Variants for ZNF554 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF554 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
788464 Benign: not provided 2,834,444(+) C/T SYNONYMOUS_VARIANT
rs867168 - p.Glu190Gly
rs867169 - p.Val211Ile

Additional dbSNP identifiers (rs#s) for ZNF554 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF554 Gene

Variant ID Type Subtype PubMed ID
esv2118962 CNV deletion 18987734
esv2673992 CNV deletion 23128226
esv2717914 CNV deletion 23290073
esv2717915 CNV deletion 23290073
esv2717916 CNV deletion 23290073
esv3643439 CNV loss 21293372
esv3643440 CNV loss 21293372
nsv1140363 CNV deletion 24896259
nsv509715 CNV insertion 20534489
nsv528638 CNV gain 19592680

Variation tolerance for ZNF554 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF554 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF554 Gene

Disorders for ZNF554 Gene

Additional Disease Information for ZNF554

No disorders were found for ZNF554 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF554 Gene

Publications for ZNF554 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for ZNF554 Gene