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Aliases for ZNF554 Gene

Aliases for ZNF554 Gene

  • Zinc Finger Protein 554 2 3 5

External Ids for ZNF554 Gene

Previous GeneCards Identifiers for ZNF554 Gene

  • GC19P002771
  • GC19P002772
  • GC19P002591

Summaries for ZNF554 Gene

GeneCards Summary for ZNF554 Gene

ZNF554 (Zinc Finger Protein 554) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF205.

UniProtKB/Swiss-Prot for ZNF554 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF554 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF554 Gene

Genomics for ZNF554 Gene

GeneHancer (GH) Regulatory Elements for ZNF554 Gene

Promoters and enhancers for ZNF554 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002819 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577 +0.1 128 1.6 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF766 CBX5 E2F8 ZNF207 ZNF143 ZNF554 GC19P002822 ZNF77 CACTIN-AS1 THOP1 CACTIN SF3A2 LOC100288123 SPPL2B ZNF556
GH19I002817 Enhancer 0.8 Ensembl 581.3 -1.9 -1874 1.2 MXI1 ESRRA FOXA2 BCL11B ZEB1 HIC1 FOSL1 ZNF366 ZNF143 TRIM24 ZNF554 GC19P002822 CACTIN CACTIN-AS1 ZNF77 SF3A2 THOP1
GH19I002781 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.3 -35.5 -35544 4.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC THOP1 SGTA ZNF554 SF3A2 APBA3 CACTIN-AS1 LOC100288123 ENSG00000267139 MOB3A DOT1L
GH19I003605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.7 +787.7 787729 4.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF766 SP3 MCM5 CACTIN-AS1 TBXA2R ZNF77 CACTIN CCDC94 ENSG00000267030 ZNF555 ENSG00000267769 APBA3 GNA11
GH19I002160 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.1 -652.1 -652134 13.7 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DOT1L CIRBP ZNF77 AP3D1 GADD45B LOC100288123 TCF3 DAZAP1 SF3A2 ENSG00000267317
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF554 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF554 gene promoter:

Genomic Locations for ZNF554 Gene

Genomic Locations for ZNF554 Gene
chr19:2,819,874-2,836,735
(GRCh38/hg38)
Size:
16,862 bases
Orientation:
Plus strand
chr19:2,819,872-2,836,733
(GRCh37/hg19)

Genomic View for ZNF554 Gene

Genes around ZNF554 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF554 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF554 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF554 Gene

Proteins for ZNF554 Gene

  • Protein details for ZNF554 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TJ5-ZN554_HUMAN
    Recommended name:
    Zinc finger protein 554
    Protein Accession:
    Q86TJ5
    Secondary Accessions:
    • Q8NAT3
    • Q9BWN3

    Protein attributes for ZNF554 Gene

    Size:
    538 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF554 Gene

Post-translational modifications for ZNF554 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF554 Gene

Domains & Families for ZNF554 Gene

Gene Families for ZNF554 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF554 Gene

Suggested Antigen Peptide Sequences for ZNF554 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TJ5

UniProtKB/Swiss-Prot:

ZN554_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF554: view

Function for ZNF554 Gene

Molecular function for ZNF554 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF554 Gene

Gene Ontology (GO) - Molecular Function for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF554: view
genes like me logo Genes that share phenotypes with ZNF554: view

miRNA for ZNF554 Gene

miRTarBase miRNAs that target ZNF554

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF554 Gene

Localization for ZNF554 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF554 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF554 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF554: view

Pathways & Interactions for ZNF554 Gene

SuperPathways for ZNF554 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF554: view

Pathways by source for ZNF554 Gene

2 Reactome pathways for ZNF554 Gene

Gene Ontology (GO) - Biological Process for ZNF554 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF554: view

No data available for SIGNOR curated interactions for ZNF554 Gene

Drugs & Compounds for ZNF554 Gene

No Compound Related Data Available

Transcripts for ZNF554 Gene

Unigene Clusters for ZNF554 Gene

Zinc finger protein 554:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF554 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for ZNF554 Gene

GeneLoc Exon Structure for
ZNF554
ECgene alternative splicing isoforms for
ZNF554

Expression for ZNF554 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF554 Gene

Protein differential expression in normal tissues from HIPED for ZNF554 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF554 Gene



Protein tissue co-expression partners for ZNF554 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF554 Gene:

ZNF554

SOURCE GeneReport for Unigene cluster for ZNF554 Gene:

Hs.307043

Evidence on tissue expression from TISSUES for ZNF554 Gene

  • Eye(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF554: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF554 Gene

Orthologs for ZNF554 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF554 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF554 33 34
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia ZNF554 33 34
  • 79.06 (n)
cow
(Bos Taurus)
Mammalia ZNF554 33 34
  • 78.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 34
  • 20 (a)
OneToMany
Species where no ortholog for ZNF554 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF554 Gene

ENSEMBL:
Gene Tree for ZNF554 (if available)
TreeFam:
Gene Tree for ZNF554 (if available)

Paralogs for ZNF554 Gene

Paralogs for ZNF554 Gene

(505) SIMAP similar genes for ZNF554 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF554: view

Variants for ZNF554 Gene

Sequence variations from dbSNP and Humsavar for ZNF554 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000127411 -- 2,823,334(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000207293 -- 2,825,404(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000213156 -- 2,830,831(+) T/C intron_variant
rs1000263844 -- 2,830,584(+) A/G intron_variant
rs1000448791 -- 2,820,145(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF554 Gene

Variant ID Type Subtype PubMed ID
nsv528638 CNV gain 19592680
nsv509715 CNV insertion 20534489
nsv1140363 CNV deletion 24896259
esv3643440 CNV loss 21293372
esv3643439 CNV loss 21293372
esv2717916 CNV deletion 23290073
esv2717915 CNV deletion 23290073
esv2717914 CNV deletion 23290073
esv2673992 CNV deletion 23128226
esv2118962 CNV deletion 18987734

Variation tolerance for ZNF554 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF554 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF554

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF554 Gene

Disorders for ZNF554 Gene

Additional Disease Information for ZNF554

No disorders were found for ZNF554 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF554 Gene

Publications for ZNF554 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58

Products for ZNF554 Gene

Sources for ZNF554 Gene

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