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Aliases for ZNF552 Gene

Aliases for ZNF552 Gene

  • Zinc Finger Protein 552 2 3 3 5

External Ids for ZNF552 Gene

Previous GeneCards Identifiers for ZNF552 Gene

  • GC19M063011
  • GC19M063012
  • GC19M058319
  • GC19M054630

Summaries for ZNF552 Gene

GeneCards Summary for ZNF552 Gene

ZNF552 (Zinc Finger Protein 552) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF814.

UniProtKB/Swiss-Prot for ZNF552 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF552 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF552 Gene

Genomics for ZNF552 Gene

GeneHancer (GH) Regulatory Elements for ZNF552 Gene

Promoters and enhancers for ZNF552 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057809 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 653.6 +2.0 1970 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF552 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586
GH19J056954 Enhancer 1.2 ENCODE dbSUPER 6.1 +857.7 857673 5.9 FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 ZNF48 ETS1 YY1 TCF12 ZNF264 ZNF805 ZNF548 ENSG00000268392 ZNF134 ZNF417 ZNF586 ZNF587 ZNF587B ZNF550
GH19J057801 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +11.3 11254 5.3 CTCF KLF1 SMAD1 SAP130 POLR2A PRDM10 IKZF2 RUNX3 ZNF202 RXRA ENSG00000269867 ZNF587 TRIM28 ZNF324B ZNF814 ZNF264 ZNF417 ZNF550 ZNF543 ZNF548
GH19J057798 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +15.8 15809 2.4 JUND ESR1 SCRT2 PRDM1 YY1 ENSG00000269867 ZNF814 ZNF587 PIR55332 ZNF552 ZNF586
GH19J057800 Enhancer 0.4 ENCODE 0.4 +14.2 14219 0.6 JUND ZKSCAN1 ZNF586 ZNF587 ZNF552 PIR55332
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF552 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF552 gene promoter:
  • E47
  • AML1a
  • FOXO3b
  • FOXO3a
  • FOXO3
  • RSRFC4
  • ISGF-3
  • FOXI1
  • HFH-3
  • NF-AT4

Genomic Locations for ZNF552 Gene

Genomic Locations for ZNF552 Gene
11,348 bases
Minus strand
11,073 bases
Minus strand

Genomic View for ZNF552 Gene

Genes around ZNF552 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF552 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF552 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF552 Gene

Proteins for ZNF552 Gene

  • Protein details for ZNF552 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 552
    Protein Accession:
    Secondary Accessions:
    • B3KUE9
    • Q6P5A6

    Protein attributes for ZNF552 Gene

    407 amino acids
    Molecular mass:
    46198 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15093.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

neXtProt entry for ZNF552 Gene

Post-translational modifications for ZNF552 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF552 Gene

No data available for DME Specific Peptides for ZNF552 Gene

Domains & Families for ZNF552 Gene

Gene Families for ZNF552 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF552 Gene

Suggested Antigen Peptide Sequences for ZNF552 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF552: view

Function for ZNF552 Gene

Molecular function for ZNF552 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF552: view
genes like me logo Genes that share phenotypes with ZNF552: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF552 Gene

Localization for ZNF552 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF552 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF552 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF552: view

Pathways & Interactions for ZNF552 Gene

SuperPathways for ZNF552 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF552: view

Pathways by source for ZNF552 Gene

2 Reactome pathways for ZNF552 Gene

Gene Ontology (GO) - Biological Process for ZNF552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF552: view

No data available for SIGNOR curated interactions for ZNF552 Gene

Drugs & Compounds for ZNF552 Gene

No Compound Related Data Available

Transcripts for ZNF552 Gene

mRNA/cDNA for ZNF552 Gene

Unigene Clusters for ZNF552 Gene

Zinc finger protein 552:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF552 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP3: - -

Relevant External Links for ZNF552 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF552 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF552 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF552 Gene

This gene is overexpressed in Bladder (x5.4) and Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ZNF552 Gene

This gene is overexpressed in Lung (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF552 Gene

Protein tissue co-expression partners for ZNF552 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF552 Gene:


SOURCE GeneReport for Unigene cluster for ZNF552 Gene:


Evidence on tissue expression from TISSUES for ZNF552 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZNF552: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF552 Gene

Orthologs for ZNF552 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF552 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF552 34 33
  • 98.85 (n)
(Canis familiaris)
Mammalia -- 34
  • 41 (a)
Species where no ortholog for ZNF552 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF552 Gene

Gene Tree for ZNF552 (if available)
Gene Tree for ZNF552 (if available)
Evolutionary constrained regions (ECRs) for ZNF552: view image

Paralogs for ZNF552 Gene

(409) SIMAP similar genes for ZNF552 Gene using alignment to 3 proteins:

  • ZN552_HUMAN
  • M0QZ81_HUMAN
  • M0R2C3_HUMAN
genes like me logo Genes that share paralogs with ZNF552: view

Variants for ZNF552 Gene

Sequence variations from dbSNP and Humsavar for ZNF552 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000044255 -- 57,816,906(-) A/G upstream_transcript_variant
rs1000739033 -- 57,807,507(-) A/G 3_prime_UTR_variant
rs1001139705 -- 57,813,744(-) T/A intron_variant
rs1001299009 -- 57,813,596(-) T/C intron_variant
rs1001807437 -- 57,811,137(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF552 Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2763213 CNV gain 21179565
esv3644911 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1055845 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv520155 CNV loss 19592680
nsv7311 OTHER inversion 18451855
nsv963084 CNV duplication 23825009

Variation tolerance for ZNF552 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF552 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF552 Gene

Disorders for ZNF552 Gene

Additional Disease Information for ZNF552

No disorders were found for ZNF552 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF552 Gene

Publications for ZNF552 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 58
  4. ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 20356460) Deng Y … Yuan W (BMB reports 2010) 3 58
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 3 58

Products for ZNF552 Gene

Sources for ZNF552 Gene

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