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Aliases for ZNF551 Gene

Aliases for ZNF551 Gene

  • Zinc Finger Protein 551 2 3 3 5
  • Zinc Finger Protein KOX23 3 4
  • KOX 23 Protein (56 AA) 3
  • KOX23 4

External Ids for ZNF551 Gene

Previous GeneCards Identifiers for ZNF551 Gene

  • GC19P062886
  • GC19P062887
  • GC19P058194
  • GC19P054505

Summaries for ZNF551 Gene

GeneCards Summary for ZNF551 Gene

ZNF551 (Zinc Finger Protein 551) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF530.

UniProtKB/Swiss-Prot for ZNF551 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF551 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF551 Gene

Genomics for ZNF551 Gene

GeneHancer (GH) Regulatory Elements for ZNF551 Gene

Promoters and enhancers for ZNF551 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 670.7 +0.2 177 1.6 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF416 ZNF207 ZNF143 ZNF551 ENSG00000269026 GC19P057683 ZNF17 ZNF549 ZNF304 ZNF134 ZNF773 ZNF446 ZNF211
GH19J058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.4 +501.3 501267 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF417 ZNF606 ZNF17 ZNF550 ZNF549 TRIM28 ZNF264 ZNF773
GH19J058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.3 +644.9 644902 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF17 ZNF446 TRIM28 ZNF549
GH19J057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 25.5 -81.9 -81932 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
GH19J058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.1 +875.1 875144 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 ZNF586 MZF1 LOC100128398
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF551 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF551 gene promoter:
  • XBP-1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • HTF
  • SRF (504 AA)
  • SRF
  • Elk-1
  • FOXF2
  • FOXO1a

Genomic Locations for ZNF551 Gene

Genomic Locations for ZNF551 Gene
chr19:57,681,969-57,717,301
(GRCh38/hg38)
Size:
35,333 bases
Orientation:
Plus strand
chr19:58,193,337-58,228,669
(GRCh37/hg19)
Size:
35,333 bases
Orientation:
Plus strand

Genomic View for ZNF551 Gene

Genes around ZNF551 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF551 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF551 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF551 Gene

Proteins for ZNF551 Gene

  • Protein details for ZNF551 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z340-ZN551_HUMAN
    Recommended name:
    Zinc finger protein 551
    Protein Accession:
    Q7Z340
    Secondary Accessions:
    • B4DU22
    • P17034
    • Q8N246
    • Q9BRY1

    Protein attributes for ZNF551 Gene

    Size:
    670 amino acids
    Molecular mass:
    77515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH05868.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF551 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF551 Gene

Post-translational modifications for ZNF551 Gene

  • Ubiquitination at isoforms=2, 3347 and isoforms=2, 3130
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF551 Gene

No data available for DME Specific Peptides for ZNF551 Gene

Domains & Families for ZNF551 Gene

Gene Families for ZNF551 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF551 Gene

Suggested Antigen Peptide Sequences for ZNF551 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z340

UniProtKB/Swiss-Prot:

ZN551_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF551: view

Function for ZNF551 Gene

Molecular function for ZNF551 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF551 Gene

Gene Ontology (GO) - Molecular Function for ZNF551 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF551: view
genes like me logo Genes that share phenotypes with ZNF551: view

Animal Model Products

miRNA for ZNF551 Gene

miRTarBase miRNAs that target ZNF551

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF551 Gene

Localization for ZNF551 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF551 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF551 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF551 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF551: view

Pathways & Interactions for ZNF551 Gene

SuperPathways for ZNF551 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF551: view

Pathways by source for ZNF551 Gene

2 Reactome pathways for ZNF551 Gene

Interacting Proteins for ZNF551 Gene

Gene Ontology (GO) - Biological Process for ZNF551 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF551: view

No data available for SIGNOR curated interactions for ZNF551 Gene

Drugs & Compounds for ZNF551 Gene

No Compound Related Data Available

Transcripts for ZNF551 Gene

mRNA/cDNA for ZNF551 Gene

Unigene Clusters for ZNF551 Gene

Zinc finger protein 551:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF551 Gene

No ASD Table

Relevant External Links for ZNF551 Gene

GeneLoc Exon Structure for
ZNF551
ECgene alternative splicing isoforms for
ZNF551

Expression for ZNF551 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF551 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF551 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF551 Gene



Protein tissue co-expression partners for ZNF551 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF551 Gene:

ZNF551

SOURCE GeneReport for Unigene cluster for ZNF551 Gene:

Hs.109540

Evidence on tissue expression from TISSUES for ZNF551 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF551: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF551 Gene

Orthologs for ZNF551 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF551 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF551 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102155192 33
  • 81.34 (n)
-- 34
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp551 33
  • 75.62 (n)
mouse
(Mus musculus)
Mammalia Zfp551 16 34 33
  • 74.93 (n)
cow
(Bos Taurus)
Mammalia ZNF551 34
  • 62 (a)
OneToOne
Species where no ortholog for ZNF551 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF551 Gene

ENSEMBL:
Gene Tree for ZNF551 (if available)
TreeFam:
Gene Tree for ZNF551 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF551: view image

Paralogs for ZNF551 Gene

(537) SIMAP similar genes for ZNF551 Gene using alignment to 3 proteins:

  • ZN551_HUMAN
  • M0R209_HUMAN
  • M0R2M4_HUMAN

Pseudogenes.org Pseudogenes for ZNF551 Gene

genes like me logo Genes that share paralogs with ZNF551: view

Variants for ZNF551 Gene

Sequence variations from dbSNP and Humsavar for ZNF551 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000223401 -- 57,687,995(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000811365 -- 57,680,308(+) G/A upstream_transcript_variant
rs1001096376 -- 57,680,659(+) A/G upstream_transcript_variant
rs1001100668 -- 57,683,306(+) T/C intron_variant
rs1001706234 -- 57,684,203(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF551 Gene

Variant ID Type Subtype PubMed ID
nsv580402 CNV gain 21841781

Variation tolerance for ZNF551 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF551 Gene

Human Gene Mutation Database (HGMD)
ZNF551
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF551

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF551 Gene

Disorders for ZNF551 Gene

Additional Disease Information for ZNF551

No disorders were found for ZNF551 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF551 Gene

Publications for ZNF551 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for ZNF551 Gene

Sources for ZNF551 Gene

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