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Aliases for ZNF550 Gene

Aliases for ZNF550 Gene

  • Zinc Finger Protein 550 2 3 3 5

External Ids for ZNF550 Gene

Previous GeneCards Identifiers for ZNF550 Gene

  • GC19M062746
  • GC19M062747
  • GC19M058053
  • GC19M054370
  • GC19M058061

Summaries for ZNF550 Gene

GeneCards Summary for ZNF550 Gene

ZNF550 (Zinc Finger Protein 550) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF550 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF550 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF550 Gene

Genomics for ZNF550 Gene

GeneHancer (GH) Regulatory Elements for ZNF550 Gene

Promoters and enhancers for ZNF550 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057558 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 674.4 +2.0 1992 2.5 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF48 YY1 ETS1 POLR2B ELK1 ZNF550 ZNF549 ZNF134 VN1R1 ZNF264 ZNF805 TRIM28 ZNF548 ZNF543 ZNF530
GH19J058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 95.4 -621.6 -621589 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF417 ZNF606 ZNF17 ZNF550 ZNF549 TRIM28 ZNF264 ZNF773
GH19J056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 69.3 +966.2 966207 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF264 ZNF17 ZNF543 ZNF773 ZNF549 ZNF550 ENSG00000269696 ENSG00000267523
GH19J058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.5 -765.2 -765224 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF17 ZNF446 TRIM28 ZNF549
GH19J058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.3 -958.1 -958061 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 SLC27A5 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZNF274 ZNF549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF550 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF550 gene promoter:
  • Nkx5-1
  • Ik-2
  • Ik-3
  • C/EBPalpha
  • Ik-1

Genomic Locations for ZNF550 Gene

Genomic Locations for ZNF550 Gene
chr19:57,535,257-57,561,647
(GRCh38/hg38)
Size:
26,391 bases
Orientation:
Minus strand
chr19:58,046,625-58,071,231
(GRCh37/hg19)
Size:
24,607 bases
Orientation:
Minus strand

Genomic View for ZNF550 Gene

Genes around ZNF550 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF550 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF550 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF550 Gene

Proteins for ZNF550 Gene

  • Protein details for ZNF550 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z398-ZN550_HUMAN
    Recommended name:
    Zinc finger protein 550
    Protein Accession:
    Q7Z398
    Secondary Accessions:
    • B3KVF6
    • O43337
    • Q7Z6D7
    • Q8NE45

    Protein attributes for ZNF550 Gene

    Size:
    422 amino acids
    Molecular mass:
    48381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34810.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH53858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF550 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF550 Gene

Post-translational modifications for ZNF550 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF550 Gene

Domains & Families for ZNF550 Gene

Gene Families for ZNF550 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF550 Gene

Suggested Antigen Peptide Sequences for ZNF550 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z398

UniProtKB/Swiss-Prot:

ZN550_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF550: view

Function for ZNF550 Gene

Molecular function for ZNF550 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF550 Gene

Gene Ontology (GO) - Molecular Function for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF550: view
genes like me logo Genes that share phenotypes with ZNF550: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF550 Gene

Localization for ZNF550 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF550 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF550 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF550: view

Pathways & Interactions for ZNF550 Gene

SuperPathways for ZNF550 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF550: view

Pathways by source for ZNF550 Gene

2 Reactome pathways for ZNF550 Gene

Gene Ontology (GO) - Biological Process for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF550: view

No data available for SIGNOR curated interactions for ZNF550 Gene

Drugs & Compounds for ZNF550 Gene

No Compound Related Data Available

Transcripts for ZNF550 Gene

mRNA/cDNA for ZNF550 Gene

Unigene Clusters for ZNF550 Gene

Zinc finger protein 550:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF550 Gene

No ASD Table

Relevant External Links for ZNF550 Gene

GeneLoc Exon Structure for
ZNF550
ECgene alternative splicing isoforms for
ZNF550

Expression for ZNF550 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF550 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF550 Gene:

ZNF550

SOURCE GeneReport for Unigene cluster for ZNF550 Gene:

Hs.180257

Evidence on tissue expression from TISSUES for ZNF550 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF550: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF550 Gene

Orthologs for ZNF550 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF550 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF550 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF550 34 33
  • 84.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF550 34 33
  • 78.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 35 (a)
ManyToMany
CU138542.3 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF550 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF550 Gene

ENSEMBL:
Gene Tree for ZNF550 (if available)
TreeFam:
Gene Tree for ZNF550 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF550: view image

Paralogs for ZNF550 Gene

Paralogs for ZNF550 Gene

(517) SIMAP similar genes for ZNF550 Gene using alignment to 3 proteins:

  • ZN550_HUMAN
  • M0QWZ8_HUMAN
  • M0R337_HUMAN
genes like me logo Genes that share paralogs with ZNF550: view

Variants for ZNF550 Gene

Sequence variations from dbSNP and Humsavar for ZNF550 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003470 -- 57,553,769(-) G/A intron_variant
rs1000183925 -- 57,545,838(-) C/T intron_variant
rs1000231384 -- 57,545,538(-) ACA/ACACA intron_variant
rs1000239305 -- 57,553,555(-) T/A/C intron_variant
rs1000344498 -- 57,551,556(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF550 Gene

Variant ID Type Subtype PubMed ID
esv3644905 CNV loss 21293372

Variation tolerance for ZNF550 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF550 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF550

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF550 Gene

Disorders for ZNF550 Gene

Additional Disease Information for ZNF550

No disorders were found for ZNF550 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF550 Gene

Publications for ZNF550 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF550 Gene

Sources for ZNF550 Gene

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