Aliases for ZNF550 Gene

Aliases for ZNF550 Gene

  • Zinc Finger Protein 550 2 3 4 5

External Ids for ZNF550 Gene

Previous GeneCards Identifiers for ZNF550 Gene

  • GC19M062746
  • GC19M062747
  • GC19M058053
  • GC19M054370
  • GC19M058061

Summaries for ZNF550 Gene

GeneCards Summary for ZNF550 Gene

ZNF550 (Zinc Finger Protein 550) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF264.

UniProtKB/Swiss-Prot Summary for ZNF550 Gene

Additional gene information for ZNF550 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF550 Gene

Genomics for ZNF550 Gene

GeneHancer (GH) Regulatory Elements for ZNF550 Gene

Promoters and enhancers for ZNF550 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF550 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF550

Top Transcription factor binding sites by QIAGEN in the ZNF550 gene promoter:
  • C/EBPalpha
  • Ik-1
  • Ik-2
  • Ik-3
  • Nkx5-1

Genomic Locations for ZNF550 Gene

Genomic Locations for ZNF550 Gene
chr19:57,535,257-57,561,647
(GRCh38/hg38)
Size:
26,391 bases
Orientation:
Minus strand
chr19:58,046,625-58,071,231
(GRCh37/hg19)
Size:
24,607 bases
Orientation:
Minus strand

Genomic View for ZNF550 Gene

Genes around ZNF550 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF550 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF550 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF550 Gene

Proteins for ZNF550 Gene

  • Protein details for ZNF550 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z398-ZN550_HUMAN
    Recommended name:
    Zinc finger protein 550
    Protein Accession:
    Q7Z398
    Secondary Accessions:
    • B3KVF6
    • O43337
    • Q7Z6D7
    • Q8NE45

    Protein attributes for ZNF550 Gene

    Size:
    422 amino acids
    Molecular mass:
    48381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34810.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH53858.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF550 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF550 Gene

Post-translational modifications for ZNF550 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF550 Gene

Domains & Families for ZNF550 Gene

Gene Families for ZNF550 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF550 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF550 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 550 (ZN550_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z398

UniProtKB/Swiss-Prot:

ZN550_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF550: view

Function for ZNF550 Gene

Molecular function for ZNF550 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF550 Gene

Gene Ontology (GO) - Molecular Function for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF550: view
genes like me logo Genes that share phenotypes with ZNF550: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF550 Gene

Localization for ZNF550 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF550 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF550 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF550: view

Pathways & Interactions for ZNF550 Gene

genes like me logo Genes that share pathways with ZNF550: view

Pathways by source for ZNF550 Gene

2 Reactome pathways for ZNF550 Gene
1 KEGG pathway for ZNF550 Gene

Gene Ontology (GO) - Biological Process for ZNF550 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF550: view

No data available for SIGNOR curated interactions for ZNF550 Gene

Drugs & Compounds for ZNF550 Gene

No Compound Related Data Available

Transcripts for ZNF550 Gene

mRNA/cDNA for ZNF550 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF550 Gene

No ASD Table

Relevant External Links for ZNF550 Gene

GeneLoc Exon Structure for
ZNF550

Expression for ZNF550 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF550 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF550

SOURCE GeneReport for Unigene cluster for ZNF550 Gene:

Hs.180257

Evidence on tissue expression from TISSUES for ZNF550 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF550: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF550 Gene

Orthologs for ZNF550 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF550 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF550 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF550 31 30
  • 84.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF550 31 30
  • 78.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 29 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 35 (a)
ManyToMany
CU138542.3 31
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF550 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF550 Gene

ENSEMBL:
Gene Tree for ZNF550 (if available)
TreeFam:
Gene Tree for ZNF550 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF550: view image

Paralogs for ZNF550 Gene

(517) SIMAP similar genes for ZNF550 Gene using alignment to 3 proteins:

  • ZN550_HUMAN
  • M0QWZ8_HUMAN
  • M0R337_HUMAN
genes like me logo Genes that share paralogs with ZNF550: view

Variants for ZNF550 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF550 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1548476 - p.Ile359Thr

Additional dbSNP identifiers (rs#s) for ZNF550 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF550 Gene

Variant ID Type Subtype PubMed ID
esv3644905 CNV loss 21293372

Variation tolerance for ZNF550 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF550 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF550

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF550 Gene

Disorders for ZNF550 Gene

Additional Disease Information for ZNF550

No disorders were found for ZNF550 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF550 Gene

Publications for ZNF550 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for ZNF550 Gene

Sources for ZNF550 Gene