Aliases for ZNF546 Gene

Aliases for ZNF546 Gene

  • Zinc Finger Protein 546 2 3 4 5
  • Zinc Finger Protein 49 3 4
  • ZNF49 3 4
  • CTC-471F3.6 3

External Ids for ZNF546 Gene

Previous HGNC Symbols for ZNF546 Gene

  • ZNF49

Previous GeneCards Identifiers for ZNF546 Gene

  • GC19P045195
  • GC19P045196
  • GC19P040503
  • GC19P036939

Summaries for ZNF546 Gene

GeneCards Summary for ZNF546 Gene

ZNF546 (Zinc Finger Protein 546) is a Protein Coding gene. Diseases associated with ZNF546 include Glycogen Storage Disease Ixb and Glycogen Storage Disease Ix. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF540.

UniProtKB/Swiss-Prot Summary for ZNF546 Gene

Additional gene information for ZNF546 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF546 Gene

Genomics for ZNF546 Gene

GeneHancer (GH) Regulatory Elements for ZNF546 Gene

Promoters and enhancers for ZNF546 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF546 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF546

Top Transcription factor binding sites by QIAGEN in the ZNF546 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • FOXD1
  • Ik-3
  • p53
  • TGIF

Genomic Locations for ZNF546 Gene

Genomic Locations for ZNF546 Gene
chr19:39,984,134-40,021,041
(GRCh38/hg38)
Size:
36,908 bases
Orientation:
Plus strand
chr19:40,490,041-40,523,514
(GRCh37/hg19)
Size:
33,474 bases
Orientation:
Plus strand

Genomic View for ZNF546 Gene

Genes around ZNF546 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF546 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF546 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF546 Gene

Proteins for ZNF546 Gene

  • Protein details for ZNF546 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE3-ZN546_HUMAN
    Recommended name:
    Zinc finger protein 546
    Protein Accession:
    Q86UE3
    Secondary Accessions:
    • A8K913

    Protein attributes for ZNF546 Gene

    Size:
    836 amino acids
    Molecular mass:
    98405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF546 Gene

Post-translational modifications for ZNF546 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF546 Gene

Domains & Families for ZNF546 Gene

Gene Families for ZNF546 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF546 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF546 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 49 (ZN546_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UE3

UniProtKB/Swiss-Prot:

ZN546_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF546: view

Function for ZNF546 Gene

Molecular function for ZNF546 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF546 Gene

Gene Ontology (GO) - Molecular Function for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF546: view
genes like me logo Genes that share phenotypes with ZNF546: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF546 Gene

Localization for ZNF546 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF546 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF546 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF546: view

Pathways & Interactions for ZNF546 Gene

genes like me logo Genes that share pathways with ZNF546: view

Pathways by source for ZNF546 Gene

2 Reactome pathways for ZNF546 Gene
1 KEGG pathway for ZNF546 Gene

Interacting Proteins for ZNF546 Gene

;

Gene Ontology (GO) - Biological Process for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF546: view

No data available for SIGNOR curated interactions for ZNF546 Gene

Drugs & Compounds for ZNF546 Gene

No Compound Related Data Available

Transcripts for ZNF546 Gene

mRNA/cDNA for ZNF546 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for ZNF546 Gene

GeneLoc Exon Structure for
ZNF546

Expression for ZNF546 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF546 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF546 Gene

This gene is overexpressed in Testis (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF546 Gene



Protein tissue co-expression partners for ZNF546 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF546

SOURCE GeneReport for Unigene cluster for ZNF546 Gene:

Hs.666807
genes like me logo Genes that share expression patterns with ZNF546: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF546 Gene

Orthologs for ZNF546 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF546 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF546 31 30
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF546 31 30
  • 82.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100363065 30
  • 60.81 (n)
mouse
(Mus musculus)
Mammalia Zfp11 17 31 30
  • 60.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF252 31
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egrh-2 30
  • 55.06 (n)
Species where no ortholog for ZNF546 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF546 Gene

ENSEMBL:
Gene Tree for ZNF546 (if available)
TreeFam:
Gene Tree for ZNF546 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF546: view image

Paralogs for ZNF546 Gene

Paralogs for ZNF546 Gene