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Aliases for ZNF546 Gene

Aliases for ZNF546 Gene

  • Zinc Finger Protein 546 2 3 5
  • Zinc Finger Protein 49 3 4
  • ZNF49 3 4
  • CTC-471F3.6 3

External Ids for ZNF546 Gene

Previous HGNC Symbols for ZNF546 Gene

  • ZNF49

Previous GeneCards Identifiers for ZNF546 Gene

  • GC19P045195
  • GC19P045196
  • GC19P040503
  • GC19P036939

Summaries for ZNF546 Gene

GeneCards Summary for ZNF546 Gene

ZNF546 (Zinc Finger Protein 546) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF780A.

UniProtKB/Swiss-Prot for ZNF546 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF546 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF546 Gene

Genomics for ZNF546 Gene

GeneHancer (GH) Regulatory Elements for ZNF546 Gene

Promoters and enhancers for ZNF546 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I039995 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 571 +13.2 13166 2.9 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF546 GC19M039992 CYP2G1P SNRPA FBL ZNF780B SUPT5H FCGBP ENSG00000269843 PAK4
GH19I039397 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.7 -577.1 -577059 20 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36 PLEKHG2 HNRNPL ZNF780B FBL ZNF780A SUPT5H AKT2 RN7SL566P RPS16
GH19I040796 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.7 +818.2 818203 11.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 SP3 EGLN2 ENSG00000268797 ZNF780B HNRNPUL1 SNRPA ENSG00000269843 NUMBL CCDC97 ZNF546 COQ8B
GH19I040713 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 +734.2 734214 9.2 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ITPKC COQ8B SNRPA HNRNPUL1 ENSG00000269843 ZNF780B CCDC97 FBL AKT2 ZNF780A
GH19I039427 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.6 -552.0 -551988 9.7 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF416 ZNF143 SP3 NFYC RPS16 HNRNPL FBL ZNF780B AKT2 PLEKHG2 RN7SL566P SUPT5H ENSG00000269688 EID2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF546 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF546 gene promoter:

Genomic Locations for ZNF546 Gene

Genomic Locations for ZNF546 Gene
chr19:39,984,134-40,021,041
(GRCh38/hg38)
Size:
36,908 bases
Orientation:
Plus strand
chr19:40,490,041-40,523,514
(GRCh37/hg19)

Genomic View for ZNF546 Gene

Genes around ZNF546 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF546 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF546 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF546 Gene

Proteins for ZNF546 Gene

  • Protein details for ZNF546 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE3-ZN546_HUMAN
    Recommended name:
    Zinc finger protein 546
    Protein Accession:
    Q86UE3
    Secondary Accessions:
    • A8K913

    Protein attributes for ZNF546 Gene

    Size:
    836 amino acids
    Molecular mass:
    98405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF546 Gene

Post-translational modifications for ZNF546 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF546 Gene

Domains & Families for ZNF546 Gene

Gene Families for ZNF546 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF546 Gene

Suggested Antigen Peptide Sequences for ZNF546 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UE3

UniProtKB/Swiss-Prot:

ZN546_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF546: view

Function for ZNF546 Gene

Molecular function for ZNF546 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF546 Gene

Gene Ontology (GO) - Molecular Function for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF546: view
genes like me logo Genes that share phenotypes with ZNF546: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF546 Gene

Localization for ZNF546 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF546 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF546 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF546: view

Pathways & Interactions for ZNF546 Gene

SuperPathways for ZNF546 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF546: view

Pathways by source for ZNF546 Gene

2 Reactome pathways for ZNF546 Gene

Interacting Proteins for ZNF546 Gene

Gene Ontology (GO) - Biological Process for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF546: view

No data available for SIGNOR curated interactions for ZNF546 Gene

Drugs & Compounds for ZNF546 Gene

No Compound Related Data Available

Transcripts for ZNF546 Gene

Unigene Clusters for ZNF546 Gene

Zinc finger protein 546:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for ZNF546 Gene

GeneLoc Exon Structure for
ZNF546
ECgene alternative splicing isoforms for
ZNF546

Expression for ZNF546 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF546 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF546 Gene

This gene is overexpressed in Testis (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF546 Gene



Protein tissue co-expression partners for ZNF546 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF546 Gene:

ZNF546

SOURCE GeneReport for Unigene cluster for ZNF546 Gene:

Hs.666807
genes like me logo Genes that share expression patterns with ZNF546: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF546 Gene

Orthologs for ZNF546 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF546 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF546 33 34
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia ZNF546 33 34
  • 82.87 (n)
rat
(Rattus norvegicus)
Mammalia LOC100363065 33
  • 60.81 (n)
mouse
(Mus musculus)
Mammalia Zfp11 33 16 34
  • 60.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF252 34
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egrh-2 33
  • 55.06 (n)
Species where no ortholog for ZNF546 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF546 Gene

ENSEMBL:
Gene Tree for ZNF546 (if available)
TreeFam:
Gene Tree for ZNF546 (if available)

Paralogs for ZNF546 Gene

(543) SIMAP similar genes for ZNF546 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF546: view

Variants for ZNF546 Gene

Sequence variations from dbSNP and Humsavar for ZNF546 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_035587 A breast cancer sample p.Leu15Val
rs1000019536 -- 40,005,974(+) T/G intron_variant
rs1000025413 -- 40,001,688(+) T/G intron_variant
rs1000048759 -- 39,994,908(+) T/C upstream_transcript_variant
rs1000056404 -- 40,000,416(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF546 Gene

Variant ID Type Subtype PubMed ID
esv2758760 CNV gain 17122850

Variation tolerance for ZNF546 Gene

Residual Variation Intolerance Score: 81.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF546 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF546

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF546 Gene

Disorders for ZNF546 Gene

Additional Disease Information for ZNF546

No disorders were found for ZNF546 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF546 Gene

Publications for ZNF546 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF546 Gene