Aliases for ZNF546 Gene

Aliases for ZNF546 Gene

  • Zinc Finger Protein 546 2 3 4 5
  • Zinc Finger Protein 49 3 4
  • ZNF49 3 4
  • CTC-471F3.6 3
  • MGC43537 2
  • ZNF546 5

External Ids for ZNF546 Gene

Previous HGNC Symbols for ZNF546 Gene

  • ZNF49

Previous GeneCards Identifiers for ZNF546 Gene

  • GC19P045195
  • GC19P045196
  • GC19P040503
  • GC19P036939

Summaries for ZNF546 Gene

GeneCards Summary for ZNF546 Gene

ZNF546 (Zinc Finger Protein 546) is a Protein Coding gene. Diseases associated with ZNF546 include Kartagener Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot Summary for ZNF546 Gene

Additional gene information for ZNF546 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF546 Gene

Genomics for ZNF546 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF546 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF546 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF546

Top Transcription factor binding sites by QIAGEN in the ZNF546 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • FOXD1
  • Ik-3
  • p53
  • TGIF

Genomic Locations for ZNF546 Gene

Genomic Locations for ZNF546 Gene
chr19:39,984,134-40,021,038
(GRCh38/hg38)
Size:
36,905 bases
Orientation:
Plus strand
chr19:40,490,041-40,523,514
(GRCh37/hg19)
Size:
33,474 bases
Orientation:
Plus strand

Genomic View for ZNF546 Gene

Genes around ZNF546 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF546 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF546 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF546 Gene

Proteins for ZNF546 Gene

  • Protein details for ZNF546 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE3-ZN546_HUMAN
    Recommended name:
    Zinc finger protein 546
    Protein Accession:
    Q86UE3
    Secondary Accessions:
    • A8K913

    Protein attributes for ZNF546 Gene

    Size:
    836 amino acids
    Molecular mass:
    98405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF546 Gene

Post-translational modifications for ZNF546 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF546 Gene

Domains & Families for ZNF546 Gene

Gene Families for ZNF546 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF546 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF546 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 49 (ZN546_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UE3

UniProtKB/Swiss-Prot:

ZN546_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF546: view

Function for ZNF546 Gene

Molecular function for ZNF546 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF546 Gene

Gene Ontology (GO) - Molecular Function for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF546: view
genes like me logo Genes that share phenotypes with ZNF546: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF546

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF546 Gene

Localization for ZNF546 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF546 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF546 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF546: view

Pathways & Interactions for ZNF546 Gene

genes like me logo Genes that share pathways with ZNF546: view

Pathways by source for ZNF546 Gene

2 Reactome pathways for ZNF546 Gene
1 KEGG pathway for ZNF546 Gene

Interacting Proteins for ZNF546 Gene

Gene Ontology (GO) - Biological Process for ZNF546 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF546: view

No data available for SIGNOR curated interactions for ZNF546 Gene

Drugs & Compounds for ZNF546 Gene

No Compound Related Data Available

Transcripts for ZNF546 Gene

mRNA/cDNA for ZNF546 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF546

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF546 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for ZNF546 Gene

GeneLoc Exon Structure for
ZNF546

Expression for ZNF546 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF546 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZNF546 Gene

This gene is overexpressed in Testis (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF546 Gene



Protein tissue co-expression partners for ZNF546 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF546

SOURCE GeneReport for Unigene cluster for ZNF546 Gene:

Hs.666807
genes like me logo Genes that share expression patterns with ZNF546: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF546 Gene

Orthologs for ZNF546 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF546 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF546 30 31
  • 99.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF546 30 31
  • 82.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100363065 30
  • 60.81 (n)
Mouse
(Mus musculus)
Mammalia Zfp11 30 17 31
  • 60.22 (n)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia ZNF252 31
  • 41 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea egrh-2 30
  • 55.06 (n)
Species where no ortholog for ZNF546 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF546 Gene

ENSEMBL:
Gene Tree for ZNF546 (if available)
TreeFam:
Gene Tree for ZNF546 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF546: view image

Paralogs for ZNF546 Gene

Paralogs for ZNF546 Gene

(543) SIMAP similar genes for ZNF546 Gene using alignment to 6 proteins:

  • ZN546_HUMAN
  • M0QXH5_HUMAN
  • M0QXR6_HUMAN
  • M0QY24_HUMAN
  • M0QZB2_HUMAN
  • M0R292_HUMAN
genes like me logo Genes that share paralogs with ZNF546: view

Variants for ZNF546 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF546 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_035587 A breast cancer sample p.Leu15Val
rs12373540 - p.Leu652Phe
rs12460371 - p.Glu427Gly
rs17710336 - p.Val298Glu
rs17854378 - p.Gln201Arg

Additional dbSNP identifiers (rs#s) for ZNF546 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF546 Gene

Variant ID Type Subtype PubMed ID
esv2758760 CNV gain 17122850

Variation tolerance for ZNF546 Gene

Residual Variation Intolerance Score: 81.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF546 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF546

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF546 Gene

Disorders for ZNF546 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF546 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kartagener syndrome
  • kartagener's syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF546: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF546 Gene

Publications for ZNF546 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF546 Gene