Aliases for ZNF544 Gene

Aliases for ZNF544 Gene

  • Zinc Finger Protein 544 2 3 4 5
  • Zinc Finger Protein AF020591 2

External Ids for ZNF544 Gene

Previous GeneCards Identifiers for ZNF544 Gene

  • GC00U914382
  • GC19P063061
  • GC19P063433
  • GC19P058740
  • GC19P055050

Summaries for ZNF544 Gene

GeneCards Summary for ZNF544 Gene

ZNF544 (Zinc Finger Protein 544) is a Protein Coding gene. Diseases associated with ZNF544 include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF12.

UniProtKB/Swiss-Prot Summary for ZNF544 Gene

Additional gene information for ZNF544 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF544 Gene

Genomics for ZNF544 Gene

GeneHancer (GH) Regulatory Elements for ZNF544 Gene

Promoters and enhancers for ZNF544 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF544 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF544 gene promoter:
  • ATF-2
  • CRE-BP1
  • CREB
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • RSRFC4

Genomic Locations for ZNF544 Gene

Genomic Locations for ZNF544 Gene
49,713 bases
Plus strand
48,856 bases
Plus strand

Genomic View for ZNF544 Gene

Genes around ZNF544 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF544 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF544 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF544 Gene

Proteins for ZNF544 Gene

  • Protein details for ZNF544 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 544
    Protein Accession:
    Secondary Accessions:
    • A8K6J1
    • Q9UEX4

    Protein attributes for ZNF544 Gene

    715 amino acids
    Molecular mass:
    81742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF544 Gene

Post-translational modifications for ZNF544 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF544 Gene

Domains & Families for ZNF544 Gene

Gene Families for ZNF544 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF544 Gene

Suggested Antigen Peptide Sequences for ZNF544 Gene

GenScript: Design optimal peptide antigens:
  • ZNF544 protein (Q8IVS5_HUMAN)
  • Zinc finger protein 544 (ZN544_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF544: view

Function for ZNF544 Gene

Molecular function for ZNF544 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF544 Gene

Gene Ontology (GO) - Molecular Function for ZNF544 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF544: view
genes like me logo Genes that share phenotypes with ZNF544: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF544 Gene

Localization for ZNF544 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF544 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF544 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF544 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF544: view

Pathways & Interactions for ZNF544 Gene

genes like me logo Genes that share pathways with ZNF544: view

Pathways by source for ZNF544 Gene

2 Reactome pathways for ZNF544 Gene
1 KEGG pathway for ZNF544 Gene

Gene Ontology (GO) - Biological Process for ZNF544 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF544: view

No data available for SIGNOR curated interactions for ZNF544 Gene

Drugs & Compounds for ZNF544 Gene

No Compound Related Data Available

Transcripts for ZNF544 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF544 Gene

No ASD Table

Relevant External Links for ZNF544 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF544 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF544 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF544 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF544 Gene:


SOURCE GeneReport for Unigene cluster for ZNF544 Gene:


Evidence on tissue expression from TISSUES for ZNF544 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF544: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF544 Gene

Orthologs for ZNF544 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF544 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF544 33 32
  • 99.39 (n)
(Canis familiaris)
Mammalia ZNF544 32
  • 73.03 (n)
-- 33
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 45 (a)
(Bos Taurus)
Mammalia -- 33
  • 42 (a)
(Gallus gallus)
Aves -- 33
  • 37 (a)
Species where no ortholog for ZNF544 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF544 Gene

Gene Tree for ZNF544 (if available)
Gene Tree for ZNF544 (if available)
Evolutionary constrained regions (ECRs) for ZNF544: view image

Paralogs for ZNF544 Gene

Paralogs for ZNF544 Gene

(571) SIMAP similar genes for ZNF544 Gene using alignment to 9 proteins:

  • ZN544_HUMAN
  • M0QX86_HUMAN
  • M0QY11_HUMAN
  • M0R0U7_HUMAN
  • M0R2F0_HUMAN
genes like me logo Genes that share paralogs with ZNF544: view

Variants for ZNF544 Gene

Sequence variations from dbSNP and Humsavar for ZNF544 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000043873 -- 58,270,191(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000046687 -- 58,266,597(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000057571 -- 58,228,077(+) C/T upstream_transcript_variant
rs1000108186 -- 58,273,041(+) T/C/G genic_downstream_transcript_variant, intron_variant
rs1000135441 -- 58,260,680(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF544 Gene

Variant ID Type Subtype PubMed ID
dgv1827n106 CNV deletion 24896259
esv1001037 CNV deletion 20482838
esv1435930 CNV deletion 17803354
esv1513336 CNV insertion 17803354
esv2087272 CNV deletion 18987734
esv2664815 CNV deletion 23128226
esv3556693 CNV deletion 23714750
esv3644928 CNV loss 21293372
esv3644929 CNV loss 21293372
esv3644930 CNV loss 21293372
esv3644931 CNV gain 21293372
esv989961 CNV insertion 20482838
nsv1058109 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv833886 CNV gain 17160897
nsv833887 CNV loss 17160897

Variation tolerance for ZNF544 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF544 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF544 Gene

Disorders for ZNF544 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF544 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • adhd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF544

genes like me logo Genes that share disorders with ZNF544: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF544 Gene

Publications for ZNF544 Gene

  1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56

Products for ZNF544 Gene

Sources for ZNF544 Gene