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Aliases for ZNF543 Gene

Aliases for ZNF543 Gene

  • Zinc Finger Protein 543 2 3 3 5

External Ids for ZNF543 Gene

Previous GeneCards Identifiers for ZNF543 Gene

  • GC00U914381
  • GC19P062525
  • GC19P062523
  • GC19P057831
  • GC19P054146

Summaries for ZNF543 Gene

GeneCards Summary for ZNF543 Gene

ZNF543 (Zinc Finger Protein 543) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF543 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF543 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF543 Gene

Genomics for ZNF543 Gene

GeneHancer (GH) Regulatory Elements for ZNF543 Gene

Promoters and enhancers for ZNF543 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057319 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 659.5 +0.3 308 2.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 ZNF543 ZNF805 ZNF548 ZNF304 ZNF586 ZNF264 ZNF274 ZNF587B TRAPPC2B ZNF547
GH19J057321 Enhancer 0.3 ENCODE 650.7 +1.5 1451 0.2 RUNX3 ZNF543 ZNF304 TRAPPC2B ZNF547 ZNF805 AURKC ZNF256 RPL19P19 USP29 VN1R1
GH19J056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 86.7 -725.1 -725057 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF264 ZNF17 ZNF543 ZNF773 ZNF549 ZNF550 ENSG00000269696 ENSG00000267523
GH19J058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 77.2 +862.7 862739 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF417 ZNF606 ZNF17 ZNF550 ZNF549 TRIM28 ZNF264 ZNF773
GH19J057809 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 32 +492.7 492721 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF552 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF543 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF543 gene promoter:
  • POU2F1
  • POU2F1a
  • Ik-1
  • p300

Genomic Locations for ZNF543 Gene

Genomic Locations for ZNF543 Gene
10,280 bases
Plus strand
10,280 bases
Plus strand

Genomic View for ZNF543 Gene

Genes around ZNF543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF543 Gene

Proteins for ZNF543 Gene

  • Protein details for ZNF543 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 543
    Protein Accession:
    Secondary Accessions:
    • Q495U9
    • Q495V0
    • Q6ZMP4
    • Q8NCX4

    Protein attributes for ZNF543 Gene

    600 amino acids
    Molecular mass:
    68404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF543 Gene

Post-translational modifications for ZNF543 Gene

  • Ubiquitination at isoforms=337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF543 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF543 Gene

Domains & Families for ZNF543 Gene

Gene Families for ZNF543 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF543 Gene

Suggested Antigen Peptide Sequences for ZNF543 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF543: view

Function for ZNF543 Gene

Molecular function for ZNF543 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF543 Gene

Gene Ontology (GO) - Molecular Function for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF543: view
genes like me logo Genes that share phenotypes with ZNF543: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF543 Gene

Localization for ZNF543 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF543 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF543 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Pathways & Interactions for ZNF543 Gene

SuperPathways for ZNF543 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF543: view

Pathways by source for ZNF543 Gene

2 Reactome pathways for ZNF543 Gene

Gene Ontology (GO) - Biological Process for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF543: view

No data available for SIGNOR curated interactions for ZNF543 Gene

Drugs & Compounds for ZNF543 Gene

No Compound Related Data Available

Transcripts for ZNF543 Gene

mRNA/cDNA for ZNF543 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF543 Gene

Zinc finger protein 543:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF543 Gene

No ASD Table

Relevant External Links for ZNF543 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF543 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF543 Gene

Protein differential expression in normal tissues from HIPED for ZNF543 Gene

This gene is overexpressed in Spinal cord (38.3) and Frontal cortex (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF543 Gene

Protein tissue co-expression partners for ZNF543 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF543 Gene:


SOURCE GeneReport for Unigene cluster for ZNF543 Gene:

genes like me logo Genes that share expression patterns with ZNF543: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF543 Gene

Orthologs for ZNF543 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF543 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF543 34 33
  • 98.94 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 51 (a)
CU138542.3 34
  • 45 (a)
Species where no ortholog for ZNF543 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF543 Gene

Gene Tree for ZNF543 (if available)
Gene Tree for ZNF543 (if available)
Evolutionary constrained regions (ECRs) for ZNF543: view image

Paralogs for ZNF543 Gene

Paralogs for ZNF543 Gene

(496) SIMAP similar genes for ZNF543 Gene using alignment to 1 proteins:

  • ZN543_HUMAN
genes like me logo Genes that share paralogs with ZNF543: view

Variants for ZNF543 Gene

Sequence variations from dbSNP and Humsavar for ZNF543 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000102991 -- 57,323,784(+) A/G coding_sequence_variant, missense_variant
rs1000267660 -- 57,327,058(+) G/A intron_variant
rs1000293496 -- 57,321,186(+) C/T intron_variant
rs1000324093 -- 57,321,401(+) C/T intron_variant
rs1000432277 -- 57,321,332(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF543 Gene

Variant ID Type Subtype PubMed ID
dgv602n67 CNV gain 20364138
esv2531361 CNV insertion 19546169
esv25537 CNV gain 19812545
esv2659236 CNV deletion 23128226
esv3644901 CNV loss 21293372
esv3893257 CNV loss 25118596
nsv580400 CNV gain 21841781
nsv819727 CNV gain 19587683
nsv819877 CNV loss 19587683
nsv821238 CNV deletion 20802225

Variation tolerance for ZNF543 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF543 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF543 Gene

Disorders for ZNF543 Gene

Additional Disease Information for ZNF543

No disorders were found for ZNF543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF543 Gene

Publications for ZNF543 Gene

  1. Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families. (PMID: 26095808) Liu R … Wang Y (Gene 2015) 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF543 Gene

Sources for ZNF543 Gene

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