Aliases for ZNF543 Gene

Aliases for ZNF543 Gene

  • Zinc Finger Protein 543 2 3 4 5
  • DKFZp434H055 2
  • ZNF543 5

External Ids for ZNF543 Gene

Previous GeneCards Identifiers for ZNF543 Gene

  • GC00U914381
  • GC19P062525
  • GC19P062523
  • GC19P057831
  • GC19P054146

Summaries for ZNF543 Gene

GeneCards Summary for ZNF543 Gene

ZNF543 (Zinc Finger Protein 543) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF460.

UniProtKB/Swiss-Prot Summary for ZNF543 Gene

Additional gene information for ZNF543 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF543 Gene

Genomics for ZNF543 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF543 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057319 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 609.5 +0.6 629 3 ARHGAP35 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 ZNF692 POLR2A ZNF543 ZNF805 ZNF548 ZNF264 ZNF256 ZNF304 ZNF274 ZNF587B ZNF417 ZNF550
GH19J056594 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 86.7 -725.0 -724971 2.6 PRDM10 ZNF692 ZNF300 LARP7 PRDM1 ZNF143 ZSCAN4 RBFOX2 POLR2A PATZ1 ZIM2-AS1 ZNF71 ZNF71-SMIM17 U2AF2 ZNF17 ZNF543 ZNF264 ZNF773 ZNF549 ZNF550
GH19J057318 Enhancer 0.3 Ensembl 600.7 -1.7 -1671 0.4 EBF1 ENSG00000268723 LOC100288211 ZNF543 ZNF460
GH19J058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 69.3 +862.9 862920 2.8 ZNF221 ARHGAP35 SP1 CREB1 CTCF PRDM10 ZNF629 SIX5 IKZF1 ZNF692 HSALNG0127934 ZNF274 lnc-ZNF329-2 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773
GH19J057681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 39.3 +364.7 364729 8 GATAD2A CTCF ATF7 SIX5 IKZF1 NFRKB RCOR2 POLR2A GABPA ZNF143 ZNF551 ZNF134 ZNF417 ZNF773 ZNF256 ZNF264 ZNF543 ZNF17 TRIM28 ZSCAN22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF543 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF543

Top Transcription factor binding sites by QIAGEN in the ZNF543 gene promoter:
  • Ik-1
  • p300
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF543 Gene

Genomic Locations for ZNF543 Gene
chr19:57,320,472-57,330,770
(GRCh38/hg38)
Size:
10,299 bases
Orientation:
Plus strand
chr19:57,831,865-57,842,144
(GRCh37/hg19)
Size:
10,280 bases
Orientation:
Plus strand

Genomic View for ZNF543 Gene

Genes around ZNF543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF543 Gene

Proteins for ZNF543 Gene

  • Protein details for ZNF543 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08ER8-ZN543_HUMAN
    Recommended name:
    Zinc finger protein 543
    Protein Accession:
    Q08ER8
    Secondary Accessions:
    • Q495U9
    • Q495V0
    • Q6ZMP4
    • Q8NCX4

    Protein attributes for ZNF543 Gene

    Size:
    600 amino acids
    Molecular mass:
    68404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF543 Gene

Post-translational modifications for ZNF543 Gene

  • Ubiquitination at Lys337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF543 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF543 Gene

Domains & Families for ZNF543 Gene

Gene Families for ZNF543 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF543 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF543 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 543 (ZN543_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08ER8

UniProtKB/Swiss-Prot:

ZN543_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF543: view

Function for ZNF543 Gene

Molecular function for ZNF543 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF543 Gene

Gene Ontology (GO) - Molecular Function for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF543: view
genes like me logo Genes that share phenotypes with ZNF543: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF543

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF543 Gene

Localization for ZNF543 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF543 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF543 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF543: view

Pathways & Interactions for ZNF543 Gene

genes like me logo Genes that share pathways with ZNF543: view

Pathways by source for ZNF543 Gene

2 Reactome pathways for ZNF543 Gene
1 KEGG pathway for ZNF543 Gene

Gene Ontology (GO) - Biological Process for ZNF543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF543: view

No data available for SIGNOR curated interactions for ZNF543 Gene

Drugs & Compounds for ZNF543 Gene

No Compound Related Data Available

Transcripts for ZNF543 Gene

mRNA/cDNA for ZNF543 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF543

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF543 Gene

No ASD Table

Relevant External Links for ZNF543 Gene

GeneLoc Exon Structure for
ZNF543

Expression for ZNF543 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF543 Gene

Protein differential expression in normal tissues from HIPED for ZNF543 Gene

This gene is overexpressed in Spinal cord (38.3) and Frontal cortex (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF543 Gene



Protein tissue co-expression partners for ZNF543 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF543

SOURCE GeneReport for Unigene cluster for ZNF543 Gene:

Hs.202544
genes like me logo Genes that share expression patterns with ZNF543: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF543 Gene

Orthologs for ZNF543 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF543 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF543 30 31
  • 98.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 51 (a)
ManyToMany
CU138542.3 31
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF543 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF543 Gene

ENSEMBL:
Gene Tree for ZNF543 (if available)
TreeFam:
Gene Tree for ZNF543 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF543: view image

Paralogs for ZNF543 Gene

Paralogs for ZNF543 Gene

(496) SIMAP similar genes for ZNF543 Gene using alignment to 1 proteins:

  • ZN543_HUMAN
genes like me logo Genes that share paralogs with ZNF543: view

Variants for ZNF543 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF543 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
779288 Likely Benign: not provided 57,326,690(+) G/A NONSENSE
rs10410649 - p.Met573Val
rs10411486 - p.Val439Asp
rs1968090 - p.Leu246His
rs35238720 - p.Glu287Val

Additional dbSNP identifiers (rs#s) for ZNF543 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF543 Gene

Variant ID Type Subtype PubMed ID
dgv602n67 CNV gain 20364138
esv2531361 CNV insertion 19546169
esv25537 CNV gain 19812545
esv2659236 CNV deletion 23128226
esv3644901 CNV loss 21293372
esv3893257 CNV loss 25118596
nsv580400 CNV gain 21841781
nsv819727 CNV gain 19587683
nsv819877 CNV loss 19587683
nsv821238 CNV deletion 20802225

Variation tolerance for ZNF543 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF543 Gene

Human Gene Mutation Database (HGMD)
ZNF543
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF543

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF543 Gene

Disorders for ZNF543 Gene

No disorders were found for ZNF543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF543 Gene

Publications for ZNF543 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families. (PMID: 26095808) Liu R … Wang Y (Gene 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3

Products for ZNF543 Gene

Sources for ZNF543 Gene