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Aliases for ZNF541 Gene
External Ids for ZNF541 Gene
- HGNC: 25294
- Entrez Gene: 84215
- Ensembl: ENSG00000118156
- UniProtKB: Q9H0D2
Previous GeneCards Identifiers for ZNF541 Gene
- GC00U914378
- GC19M052716
- GC19M052717
- GC19M048023
- GC19M044451
Summaries for ZNF541 Gene
GeneCards Summary for ZNF541 Gene
ZNF541 (Zinc Finger Protein 541) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TRERF1.
UniProtKB/Swiss-Prot Summary for ZNF541 Gene
-
Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.
Additional gene information for ZNF541 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF541 Gene
Genomics for ZNF541 Gene
GeneHancer (GH) Regulatory Elements for ZNF541 Gene
Promoters and enhancers for ZNF541 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF541 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF541
- Top Transcription factor binding sites by QIAGEN in the ZNF541 gene promoter:
-
- AP-2gamma
- c-Myc
- FOXL1
- HNF-1
- HNF-1A
- Max1
- MRF-2
- p53
- POU2F1
- POU2F1a
Genomic Locations for ZNF541 Gene
Genomic Locations for ZNF541 Gene
- chr19:47,520,685-47,573,238
- (GRCh38/hg38)
- Size:
- 52,554 bases
- Orientation:
- Minus strand
- chr19:48,023,942-48,059,113
- (GRCh37/hg19)
- Size:
- 35,172 bases
- Orientation:
- Minus strand
Genomic View for ZNF541 Gene
Genes around ZNF541 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
ZNF541 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF541 Gene
Proteins for ZNF541 Gene
-
Protein details for ZNF541 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0D2-ZN541_HUMAN
- Recommended name:
- Zinc finger protein 541
- Protein Accession:
- Q9H0D2
- Q8NDK8
Protein attributes for ZNF541 Gene
- Size:
- 1346 amino acids
- Molecular mass:
- 145587 Da
- Quaternary structure:
-
- Interacts with DNTTIP1 (PubMed:21573134). Identified in a complex with KCDT19, HDAC1 and HSPA2 (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).
- SequenceCaution:
-
- Sequence=AAI01051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI01052.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI01053.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI01054.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB66780.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD38720.2; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for ZNF541 Gene
Post-translational modifications for ZNF541 Gene
Other Protein References for ZNF541 Gene
Antibody Products
- G Biosciences Immunotag™ ZNF541 Antibody
- Creative Diagnostics Anti-ZNF541 (aa 360-409) polyclonal antibody
- Novus Biologicals Antibodies for ZNF541
- Invitrogen Antibodies for ZNF541 (AFLGC-ZNF541)
-
Boster Bio Antibodies for ZNF541
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF541
Protein Products
-
OriGene Purified Proteins for ZNF541
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- Novus Biologicals proteins for ZNF541
No data available for DME Specific Peptides for ZNF541 Gene
Domains & Families for ZNF541 Gene
Gene Families for ZNF541 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF541 Gene
- Blocks:
-
- Myb DNA-binding domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF541 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 541 (ZN541_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF541 Gene
Function for ZNF541 Gene
Molecular function for ZNF541 Gene
- UniProtKB/Swiss-Prot Function:
- Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.
Phenotypes From GWAS Catalog for ZNF541 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
| GO:0008134 | transcription factor binding | IBA | 21873635 |
Phenotypes for ZNF541 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF541 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF541
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF541
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF541 - Select products 50% OFF >
- * ZNF541 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for ZNF541
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- genomics-online: cdna clones - Search results for available ZNF541 gene related products
- orf clones - Search results for available ZNF541 gene related products
Cell Line Products
-
Horizon Cell Lines for ZNF541
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF541 Gene
Localization for ZNF541 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF541 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | ISS | -- |
| GO:0005634 | nucleus | ISS,IEA | -- |
| GO:0005667 | transcription factor complex | IBA | 21873635 |
Pathways & Interactions for ZNF541 Gene
Interacting Proteins for ZNF541 Gene
GPS-Prot Interaction Network for ZNF541
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF541 Gene
Transcripts for ZNF541 Gene
mRNA/cDNA for ZNF541 Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263351 2573 bps (ENST00000263351.9)
- ENST00000314121 4631 bps (ENST00000314121.8)
- ENST00000391901 4580 bps (ENST00000391901.7)
- ENST00000487275 579 bps (ENST00000487275.1)
- ENST00000595558 2600 bps (ENST00000595558.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF541 - Select products 50% OFF >
- * ZNF541 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF541
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF541
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF541
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF541
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF541 - Select products 50% OFF >
- * ZNF541 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF541
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF541
- genomics-online: cdna clones - Search results for available ZNF541 gene related products
- orf clones - Search results for available ZNF541 gene related products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for ZNF541 Gene
- GeneLoc Exon Structure for
- ZNF541
Expression for ZNF541 Gene
mRNA differential expression in normal tissues according to GTEx for ZNF541 Gene
This gene is overexpressed in Testis (x30.1).
This gene is overexpressed in Pancreatic juice (40.0) and Heart (27.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF541 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF541
SOURCE GeneReport for Unigene cluster for ZNF541 Gene:
Hs.14161Primer Products
-
OriGene qPCR primer pairs for ZNF541
- genomics-online: primer clones - Search results for available ZNF541 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF541 Gene
Orthologs for ZNF541 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF541 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF541 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF541 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp541 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp541 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF541 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF541 31 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZNF541 31 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ZNF541 31 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG16779 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | saeg-1 31 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ZNF541 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ZNF541 Gene
- ENSEMBL:
- Gene Tree for ZNF541 (if available)
- TreeFam:
- Gene Tree for ZNF541 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF541: view image
Paralogs for ZNF541 Gene
(14) SIMAP similar genes for ZNF541 Gene using alignment to 3 proteins:
- ZN541_HUMAN
- H7BXG6_HUMAN
- M0R167_HUMAN
Variants for ZNF541 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF541 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs386834267 | Uncertain Significance: not provided | 47,544,921(-) | C/T | SYNONYMOUS_VARIANT | |
| VAR_035717 | A breast cancer sample | p.Ser712Leu | |||
| rs34984302 | - | p.Lys791Glu | |||
| rs3810320 | - | p.Pro486Ser | |||
| rs3826835 | - | p.Thr795Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758765 | CNV | loss | 17122850 |
| nsv1056887 | CNV | gain | 25217958 |
| nsv1131434 | CNV | deletion | 24896259 |
| nsv428366 | CNV | loss | 18775914 |
| nsv579888 | CNV | gain | 21841781 |
Gene Damage Index Score:
8.75;
86.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF541 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF541
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF541 Gene
Disorders for ZNF541 Gene
Additional Disease Information for ZNF541
No disorders were found for ZNF541 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF541 Gene
Publications for ZNF541 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- 19q13.32 microdeletion syndrome: three new cases. (PMID: 25230004) Castillo A … Graham JM (European journal of medical genetics 2014) 3 54
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
- Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. (PMID: 21573134) Hao Y … Mak HY (PLoS genetics 2011) 4 54
ExternalLinks
Products for ZNF541 Gene
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- antibodies-online: Show 12 available ZNF541 Antibodies ranked by validation data
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Sources for ZNF541 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody