Aliases for ZNF541 Gene
External Ids for ZNF541 Gene
- HGNC: 25294
- Entrez Gene: 84215
- Ensembl: ENSG00000118156
- UniProtKB: Q9H0D2
Previous GeneCards Identifiers for ZNF541 Gene
- GC00U914378
- GC19M052716
- GC19M052717
- GC19M048023
- GC19M044451
Summaries for ZNF541 Gene
GeneCards Summary for ZNF541 Gene
ZNF541 (Zinc Finger Protein 541) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is ELMSAN1.
UniProtKB/Swiss-Prot for ZNF541 Gene
-
Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.
Additional gene information for ZNF541 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF541 Gene
Genomics for ZNF541 Gene
GeneHancer (GH) Regulatory Elements for ZNF541 Gene
Promoters and enhancers for ZNF541 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF541 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF541 Gene
Genomic Locations for ZNF541 Gene
- chr19:47,520,685-47,573,238
- (GRCh38/hg38)
- Size:
- 52,554 bases
- Orientation:
- Minus strand
- chr19:48,023,942-48,059,113
- (GRCh37/hg19)
Genomic View for ZNF541 Gene
Genes around ZNF541 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
- 19q13.33 by Ensembl
ZNF541 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF541 Gene
Proteins for ZNF541 Gene
-
Protein details for ZNF541 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0D2-ZN541_HUMAN
- Recommended name:
- Zinc finger protein 541
- Protein Accession:
- Q9H0D2
- Q8NDK8
Protein attributes for ZNF541 Gene
- Size:
- 1346 amino acids
- Molecular mass:
- 145587 Da
- Quaternary structure:
-
- Interacts with DNTTIP1 (PubMed:21573134). Identified in a complex with KCDT19, HDAC1 and HSPA2 (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).
- SequenceCaution:
-
- Sequence=AAI01051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01053.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01054.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66780.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38720.2; Type=Frameshift; Positions=473; Evidence={ECO:0000305};
Protein Expression for ZNF541 Gene
Post-translational modifications for ZNF541 Gene
Other Protein References for ZNF541 Gene
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-
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Assay Products
No data available for DME Specific Peptides for ZNF541 Gene
Domains & Families for ZNF541 Gene
Gene Families for ZNF541 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF541 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF541 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZNF541 Gene
Function for ZNF541 Gene
Molecular function for ZNF541 Gene
- UniProtKB/Swiss-Prot Function:
- Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.
Phenotypes From GWAS Catalog for ZNF541 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IBA | -- |
| GO:0008134 | transcription factor binding | IBA | -- |
Phenotypes for ZNF541 Gene
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-
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF541
- genomics-online: cdna clones - Search results for available ZNF541 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF541
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF541 Gene
Localization for ZNF541 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF541 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | ISS | -- |
| GO:0005634 | nucleus | ISS,IEA | -- |
| GO:0005667 | transcription factor complex | IBA | -- |
Pathways & Interactions for ZNF541 Gene
No Data Available
Interacting Proteins for ZNF541 Gene
Selected Interacting proteins:
Q9H0D2-ZN541_HUMAN
ENSP00000313258
for ZNF541 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for ZNF541
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF541 Gene
Transcripts for ZNF541 Gene
mRNA/cDNA for ZNF541 Gene
- (22) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (14) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000263351 2573 bps (uc061amx.1)
- ENST00000314121 4631 bps (uc061amy.1)
- ENST00000391901 4580 bps (uc002phg.5)
- ENST00000487275 579 bps (uc061ana.1)
- ENST00000595558 2600 bps (uc061amz.1)
Unigene Clusters for ZNF541 Gene
- Zinc finger protein 541:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF541
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- genomics-online: gRNA clones - Search results for available ZNF541 gene related products
- Applied Biological Materials CRISPR for ZNF541
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF541
miRNA Products
Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF541
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF541
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF541
- genomics-online: cdna clones - Search results for available ZNF541 gene related products
- orf clones - Search results for available ZNF541 gene related products
- Applied Biological Materials Clones for ZNF541
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: |
Expression for ZNF541 Gene
mRNA differential expression in normal tissues according to GTEx for ZNF541 Gene
This gene is overexpressed in Testis (x30.1).
This gene is overexpressed in Pancreatic juice (40.0) and Heart (27.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF541 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF541 Gene:
ZNF541SOURCE GeneReport for Unigene cluster for ZNF541 Gene:
Hs.14161Primer Products
-
OriGene qPCR primer pairs for ZNF541
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF541 Gene
Orthologs for ZNF541 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF541 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF541 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF541 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp541 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp541 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF541 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF541 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZNF541 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ZNF541 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG16779 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | saeg-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ZNF541 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ZNF541 Gene
- ENSEMBL:
- Gene Tree for ZNF541 (if available)
- TreeFam:
- Gene Tree for ZNF541 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF541: view image
Paralogs for ZNF541 Gene
(14) SIMAP similar genes for ZNF541 Gene using alignment to 3 proteins:
- M0R167_HUMAN
- H7BXG6_HUMAN
- ZN541_HUMAN
Variants for ZNF541 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035717 | A breast cancer sample | p.Ser712Leu | |||
| rs386834267 | uncertain-significance, not provided | 47,544,921(-) | C/T | coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant | |
| rs1000016070 | -- | 47,542,841(-) | A/G | intron_variant | |
| rs1000097108 | -- | 47,547,629(-) | G/C | intron_variant | |
| rs1000200464 | -- | 47,558,358(-) | G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758765 | CNV | loss | 17122850 |
| nsv1056887 | CNV | gain | 25217958 |
| nsv1131434 | CNV | deletion | 24896259 |
| nsv428366 | CNV | loss | 18775914 |
| nsv579888 | CNV | gain | 21841781 |
Gene Damage Index Score:
8.75;
86.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF541 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF541
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF541 Gene
Disorders for ZNF541 Gene
Additional Disease Information for ZNF541
No disorders were found for ZNF541 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF541 Gene
Publications for ZNF541 Gene
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- 19q13.32 microdeletion syndrome: three new cases. (PMID: 25230004) Castillo A … Graham JM (European journal of medical genetics 2014) 3 58
- Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. (PMID: 21573134) Hao Y … Mak HY (PLoS genetics 2011) 4 58
- A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
Products for ZNF541 Gene
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
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- antibodies-online: Search results for 31 available ZNF541 Antibodies ranked by validation data
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Sources for ZNF541 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio