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The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015] See more...
Aliases for ZNF536 Gene
External Ids for ZNF536 Gene
- HGNC: 29025
- Entrez Gene: 9745
- Ensembl: ENSG00000198597
- OMIM: 618037
- UniProtKB: O15090
Previous GeneCards Identifiers for ZNF536 Gene
- GC19P035555
- GC19P030864
- GC19P027369
- GC19P030720
Summaries for ZNF536 Gene
-
The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]
GeneCards Summary for ZNF536 Gene
ZNF536 (Zinc Finger Protein 536) is a Protein Coding gene. Diseases associated with ZNF536 include Myopia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF516.
UniProtKB/Swiss-Prot Summary for ZNF536 Gene
-
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Additional gene information for ZNF536 Gene
- HGNC(29025)
- Entrez Gene(9745)
- Ensembl(ENSG00000198597)
- OMIM(618037)
- UniProtKB(O15090)
- Open Targets Platform(ENSG00000198597)
- Monarch Initiative
- Search for ZNF536 at DataMed
- Search for ZNF536 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF536 Gene
Genomics for ZNF536 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF536 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF536 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF536
- Top Transcription factor binding sites by QIAGEN in the ZNF536 gene promoter:
-
- CUTL1
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- MyoD
- Nkx3-1
- Nkx3-1 v4
Genomic Locations for ZNF536 Gene
Genomic Locations for ZNF536 Gene
- chr19:30,224,236-30,713,586
- (GRCh38/hg38)
- Size:
- 489,351 bases
- Orientation:
- Plus strand
- chr19:30,719,197-31,204,445
- (GRCh37/hg19)
- Size:
- 485,249 bases
- Orientation:
- Plus strand
Genomic View for ZNF536 Gene
Genes around ZNF536 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q12 by HGNC
- 19q12 by Entrez Gene
- 19q12 by Ensembl
ZNF536 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF536 Gene
Proteins for ZNF536 Gene
-
Protein details for ZNF536 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15090-ZN536_HUMAN
- Recommended name:
- Zinc finger protein 536
- Protein Accession:
- O15090
- A2RU18
Protein attributes for ZNF536 Gene
- Size:
- 1300 amino acids
- Molecular mass:
- 141417 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA20844.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF536 Gene
Post-translational modifications for ZNF536 Gene
Other Protein References for ZNF536 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011525856.1
- XP_011525857.1
- XP_011525859.1
- XP_011525860.1
- XP_011525862.1
- XP_016883016.1
- XP_016883017.1
- XP_016883018.1
- XP_016883019.1
- XP_016883020.1
- XP_016883021.1
- XP_016883022.1
- XP_016883023.1
- XP_016883024.1
- XP_016883025.1
- XP_016883026.1
- XP_016883027.1
- XP_016883028.1
- XP_016883029.1
- XP_016883031.1
- XP_016883032.1
- XP_024307575.1
- NP_001339189.1
- NP_001363039.1
- NP_001363040.1
- NP_055532.1
Antibody Products
- Creative Diagnostics Anti-ZNF536 (N-terminal) polyclonal antibody
-
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- Invitrogen Antibodies for ZNF536 (AFLGC-ZNF536)
-
Boster Bio Antibodies for ZNF536
-
Custom Antibody ServicesProSci Antibodies for ZNF536
Protein Products
-
OriGene Purified Proteins for ZNF536
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF536
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No data available for DME Specific Peptides for ZNF536 Gene
Domains & Families for ZNF536 Gene
Gene Families for ZNF536 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF536 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF536 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNF536 protein (A7E228_HUMAN)
- Zinc finger protein 536 (ZN536_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15090- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF536 Gene
Molecular function for ZNF536 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Phenotypes From GWAS Catalog for ZNF536 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19398580 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 19398580 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0044323 | retinoic acid-responsive element binding | IEA | -- |
Phenotypes for ZNF536 Gene
- MGI mutant phenotypes for ZNF536:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF536:
-
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased p24 protein expression
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
Animal Models for ZNF536 Gene
- MGI Knock Outs for ZNF536:
-
- Zfp536 Zfp536<tm1.1(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF536 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for ZNF536
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF536
miRNA for ZNF536 Gene
- miRTarBase miRNAs that target ZNF536
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF536 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF536
- Addgene plasmids for ZNF536
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF536
Cell Line Products
-
Horizon Cell Lines for ZNF536
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF536 Gene
Localization for ZNF536 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF536 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cell Junctions (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
Pathways & Interactions for ZNF536 Gene
Interacting Proteins for ZNF536 Gene
GPS-Prot Interaction Network for ZNF536
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 19398580 |
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
| GO:0045665 | negative regulation of neuron differentiation | IEA | -- |
| GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF536 Gene
Transcripts for ZNF536 Gene
mRNA/cDNA for ZNF536 Gene
- 4 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000355537 4973 nts (view in UCSC)
- ENST00000585628 3198 nts (view in UCSC)
- ENST00000590564 787 nts (view in UCSC)
- ENST00000591488 655 nts (view in UCSC)
- ENST00000592773 2951 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF536 - Select products 50% OFF >
- * ZNF536 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF536
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF536
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF536
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF536
- Browse OriGene Inhibitory RNA Products For ZNF536
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF536
Clone Products
- Applied Biological Materials (abm): Clones for ZNF536 - Select products 50% OFF >
- * ZNF536 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF536
- Addgene plasmids for ZNF536
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF536
Relevant External Links for ZNF536 Gene
- GeneLoc Exon Structure for
- ZNF536
Expression for ZNF536 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Medullary Stroma Cells Interstitial Stroma
- Interstitial Stroma
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for ZNF536 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4) and Brain - Substantia nigra (x4.8).
This gene is overexpressed in Liver, secretome (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF536 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF536
SOURCE GeneReport for Unigene cluster for ZNF536 Gene:
Hs.378901Evidence on tissue expression from TISSUES for ZNF536 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ZNF536
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF536 Gene
Orthologs for ZNF536 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF536 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF536 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF536 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp536 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zfp536 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZNF536 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF536 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNF536 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZNF536 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf536 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | znf536 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3642 31 |
|
OneToMany |
- Species where no ortholog for ZNF536 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF536 Gene
- ENSEMBL:
- Gene Tree for ZNF536 (if available)
- TreeFam:
- Gene Tree for ZNF536 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF536: view image
Paralogs for ZNF536 Gene
Paralogs for ZNF536 Gene
(27) SIMAP similar genes for ZNF536 Gene using alignment to 5 proteins:
- ZN536_HUMAN
- A7E228_HUMAN
- K7EJP8_HUMAN
- K7EKT4_HUMAN
- K7EQN6_HUMAN
Variants for ZNF536 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF536 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708625 | Benign: not provided | 30,534,840(+) | G/A | INTRON_VARIANT | |
| 713235 | Benign: not provided | 30,534,938(+) | G/A | SYNONYMOUS_VARIANT | |
| 715983 | Benign: not provided | 30,548,583(+) | G/A | SYNONYMOUS_VARIANT | |
| 720598 | Benign: not provided | 30,445,647(+) | C/T | SYNONYMOUS_VARIANT | |
| 729474 | Likely Benign: not provided | 30,548,350(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2007e59 | CNV | duplication | 20981092 |
| esv1248605 | CNV | insertion | 17803354 |
| esv2662362 | CNV | deletion | 23128226 |
| esv2718441 | CNV | deletion | 23290073 |
| esv2718442 | CNV | deletion | 23290073 |
| esv2718443 | CNV | deletion | 23290073 |
| esv2718444 | CNV | deletion | 23290073 |
| esv32918 | CNV | gain+loss | 17666407 |
| esv3556276 | CNV | deletion | 23714750 |
| esv3644137 | CNV | loss | 21293372 |
| esv3644138 | CNV | loss | 21293372 |
| esv8807 | CNV | loss | 19470904 |
| esv989390 | CNV | insertion | 20482838 |
| nsv1057700 | CNV | gain | 25217958 |
| nsv1072879 | CNV | deletion | 25765185 |
| nsv1146881 | CNV | deletion | 26484159 |
| nsv138500 | CNV | deletion | 16902084 |
| nsv458534 | CNV | loss | 19166990 |
| nsv476424 | CNV | novel sequence insertion | 20440878 |
| nsv579284 | CNV | loss | 21841781 |
| nsv833801 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
1.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.38;
63.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF536 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF536 Gene
Disorders for ZNF536 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myopia |
|
|
Search ZNF536 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF536
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF536 Gene
Publications for ZNF536 Gene
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
- Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 3 41
- Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T … Maeda H (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4
- Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
- USP7 Regulates Cytokinesis through FBXO38 and KIF20B. (PMID: 30804394) Georges A … Frappier L (Scientific reports 2019) 3
ExternalLinks
Products for ZNF536 Gene
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- Invitrogen Antibodies for ZNF536 (AFLGC-ZNF536)
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- Boster Bio Antibodies for ZNF536
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Sources for ZNF536 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
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