The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015] See more...

Aliases for ZNF536 Gene

Aliases for ZNF536 Gene

  • Zinc Finger Protein 536 2 3 4 5
  • KIAA0390 2 4
  • ZNF536 5

External Ids for ZNF536 Gene

Previous GeneCards Identifiers for ZNF536 Gene

  • GC19P035555
  • GC19P030864
  • GC19P027369
  • GC19P030720

Summaries for ZNF536 Gene

Entrez Gene Summary for ZNF536 Gene

  • The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

GeneCards Summary for ZNF536 Gene

ZNF536 (Zinc Finger Protein 536) is a Protein Coding gene. Diseases associated with ZNF536 include Myopia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF516.

UniProtKB/Swiss-Prot Summary for ZNF536 Gene

  • May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF536 Gene

Genomics for ZNF536 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF536 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF536 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF536

Top Transcription factor binding sites by QIAGEN in the ZNF536 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • MyoD
  • Nkx3-1
  • Nkx3-1 v4

Genomic Locations for ZNF536 Gene

Genomic Locations for ZNF536 Gene
chr19:30,224,236-30,713,586
(GRCh38/hg38)
Size:
489,351 bases
Orientation:
Plus strand
chr19:30,719,197-31,204,445
(GRCh37/hg19)
Size:
485,249 bases
Orientation:
Plus strand

Genomic View for ZNF536 Gene

Genes around ZNF536 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF536 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF536 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF536 Gene

Proteins for ZNF536 Gene

  • Protein details for ZNF536 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15090-ZN536_HUMAN
    Recommended name:
    Zinc finger protein 536
    Protein Accession:
    O15090
    Secondary Accessions:
    • A2RU18

    Protein attributes for ZNF536 Gene

    Size:
    1300 amino acids
    Molecular mass:
    141417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20844.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF536 Gene

Post-translational modifications for ZNF536 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF536 Gene

Domains & Families for ZNF536 Gene

Gene Families for ZNF536 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF536 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF536 Gene

GenScript: Design optimal peptide antigens:
  • ZNF536 protein (A7E228_HUMAN)
  • Zinc finger protein 536 (ZN536_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15090

UniProtKB/Swiss-Prot:

ZN536_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF536: view

Function for ZNF536 Gene

Molecular function for ZNF536 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.

Phenotypes From GWAS Catalog for ZNF536 Gene

Gene Ontology (GO) - Molecular Function for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19398580
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 19398580
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0044323 retinoic acid-responsive element binding IEA --
genes like me logo Genes that share ontologies with ZNF536: view
genes like me logo Genes that share phenotypes with ZNF536: view

Animal Models for ZNF536 Gene

MGI Knock Outs for ZNF536:
  • Zfp536 Zfp536<tm1.1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF536 Gene

miRTarBase miRNAs that target ZNF536

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF536

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF536 Gene

Localization for ZNF536 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF536 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF536 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF536: view

Pathways & Interactions for ZNF536 Gene

PathCards logo

SuperPathways for ZNF536 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF536 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19398580
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF536: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF536 Gene

Drugs & Compounds for ZNF536 Gene

No Compound Related Data Available

Transcripts for ZNF536 Gene

mRNA/cDNA for ZNF536 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF536

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF536 Gene

No ASD Table

Relevant External Links for ZNF536 Gene

GeneLoc Exon Structure for
ZNF536

Expression for ZNF536 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF536 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF536 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4) and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for ZNF536 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF536 Gene



Protein tissue co-expression partners for ZNF536 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF536

SOURCE GeneReport for Unigene cluster for ZNF536 Gene:

Hs.378901

Evidence on tissue expression from TISSUES for ZNF536 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF536: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF536 Gene

Orthologs for ZNF536 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF536 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF536 30 31
  • 99.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF536 30 31
  • 90.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF536 30 31
  • 89.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp536 30
  • 85.54 (n)
Mouse
(Mus musculus)
Mammalia Zfp536 30 17 31
  • 85.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF536 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF536 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF536 30 31
  • 75.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF536 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf536 30
  • 67.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii znf536 30 31
  • 62.3 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3642 31
  • 26 (a)
OneToMany
Species where no ortholog for ZNF536 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF536 Gene

ENSEMBL:
Gene Tree for ZNF536 (if available)
TreeFam:
Gene Tree for ZNF536 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF536: view image

Paralogs for ZNF536 Gene

(27) SIMAP similar genes for ZNF536 Gene using alignment to 5 proteins:

  • ZN536_HUMAN
  • A7E228_HUMAN
  • K7EJP8_HUMAN
  • K7EKT4_HUMAN
  • K7EQN6_HUMAN
genes like me logo Genes that share paralogs with ZNF536: view

Variants for ZNF536 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF536 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
708625 Benign: not provided 30,534,840(+) G/A INTRON_VARIANT
713235 Benign: not provided 30,534,938(+) G/A SYNONYMOUS_VARIANT
715983 Benign: not provided 30,548,583(+) G/A SYNONYMOUS_VARIANT
720598 Benign: not provided 30,445,647(+) C/T SYNONYMOUS_VARIANT
729474 Likely Benign: not provided 30,548,350(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF536 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF536 Gene

Variant ID Type Subtype PubMed ID
dgv2007e59 CNV duplication 20981092
esv1248605 CNV insertion 17803354
esv2662362 CNV deletion 23128226
esv2718441 CNV deletion 23290073
esv2718442 CNV deletion 23290073
esv2718443 CNV deletion 23290073
esv2718444 CNV deletion 23290073
esv32918 CNV gain+loss 17666407
esv3556276 CNV deletion 23714750
esv3644137 CNV loss 21293372
esv3644138 CNV loss 21293372
esv8807 CNV loss 19470904
esv989390 CNV insertion 20482838
nsv1057700 CNV gain 25217958
nsv1072879 CNV deletion 25765185
nsv1146881 CNV deletion 26484159
nsv138500 CNV deletion 16902084
nsv458534 CNV loss 19166990
nsv476424 CNV novel sequence insertion 20440878
nsv579284 CNV loss 21841781
nsv833801 CNV loss 17160897

Variation tolerance for ZNF536 Gene

Residual Variation Intolerance Score: 1.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF536 Gene

Human Gene Mutation Database (HGMD)
ZNF536
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF536

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF536 Gene

Disorders for ZNF536 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF536 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF536

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF536: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF536 Gene

Publications for ZNF536 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 3 41
  3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T … Maeda H (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4
  4. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  5. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. (PMID: 30804394) Georges A … Frappier L (Scientific reports 2019) 3

Products for ZNF536 Gene

Sources for ZNF536 Gene