Aliases for ZNF534 Gene

Aliases for ZNF534 Gene

  • Zinc Finger Protein 534 2 3 4 5
  • KRAB Domain Only Protein 3 3 4
  • KRAB Domain Only 3 2 3
  • KRBO3 3 4
  • FLJ25344 2
  • ZNF534 5

External Ids for ZNF534 Gene

Previous HGNC Symbols for ZNF534 Gene

  • KRBO3

Previous GeneCards Identifiers for ZNF534 Gene

  • GC19P057624
  • GC19P057592
  • GC19P052932
  • GC19P049265

Summaries for ZNF534 Gene

GeneCards Summary for ZNF534 Gene

ZNF534 (Zinc Finger Protein 534) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF528.

UniProtKB/Swiss-Prot Summary for ZNF534 Gene

Additional gene information for ZNF534 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF534 Gene

Genomics for ZNF534 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF534 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052429 Promoter 0.7 EPDnew 600.7 0.0 -19 0.1 NRF1 NFE2 ZSCAN29 ZNF316 ELF1 ZBTB33 GABPB1 ZNF534 piR-50444-235 DPPA5P1 ZNF528
GH19J052396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 20.1 -31.5 -31547 2.8 GATAD2A ZNF512 POLR2A GABPA PRDM1 RBFOX2 SMAD5 NR2C1 IRF2 TRIM22 ZNF528 ZNF528-AS1 NONHSAG026411.2 ZNF534 ZNF175 ZNF611 ENSG00000260160
GH19J052452 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 +24.7 24653 2.4 GABPA NR2C1 NRF1 ZSCAN29 ZBTB40 NR2C2 POLR2A NR2F2 CBX1 SP3 ZNF578 ENSG00000288253 lnc-ZNF534-1 ZNF534 ENSG00000269001 lnc-ZNF534-3 ZNF808
GH19J052421 Enhancer 0.2 Ensembl 0.4 -7.9 -7947 0.4 piR-40154-093 piR-52261-138 ZNF528 ZNF534 piR-36918
GH19J052422 Enhancer 0.2 Ensembl 0.4 -7.4 -7447 0.2 piR-40154-093 piR-52261-138 lnc-ZNF83-8 ZNF534 ZNF528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF534 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF534

Top Transcription factor binding sites by QIAGEN in the ZNF534 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Ik-1
  • Pax-6
  • Roaz

Genomic Locations for ZNF534 Gene

Genomic Locations for ZNF534 Gene
chr19:52,429,148-52,452,315
(GRCh38/hg38)
Size:
23,168 bases
Orientation:
Plus strand
chr19:52,932,440-52,955,568
(GRCh37/hg19)
Size:
23,129 bases
Orientation:
Plus strand

Genomic View for ZNF534 Gene

Genes around ZNF534 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF534 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF534 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF534 Gene

Proteins for ZNF534 Gene

  • Protein details for ZNF534 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KX8-ZN534_HUMAN
    Recommended name:
    Zinc finger protein 534
    Protein Accession:
    Q76KX8
    Secondary Accessions:
    • Q76KX9

    Protein attributes for ZNF534 Gene

    Size:
    674 amino acids
    Molecular mass:
    77167 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF534 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF534 Gene

Post-translational modifications for ZNF534 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF534 Gene

Domains & Families for ZNF534 Gene

Gene Families for ZNF534 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF534 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF534 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ25344 fis, clone TST01087 (Q96LN7_HUMAN)
  • KRAB domain only protein 3 (ZN534_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q76KX8

UniProtKB/Swiss-Prot:

ZN534_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF534: view

Function for ZNF534 Gene

Molecular function for ZNF534 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF534: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF534

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF534 Gene

Localization for ZNF534 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF534 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF534 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF534: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF534 Gene

Pathways & Interactions for ZNF534 Gene

PathCards logo

SuperPathways for ZNF534 Gene

genes like me logo Genes that share pathways with ZNF534: view

Pathways by source for ZNF534 Gene

1 KEGG pathway for ZNF534 Gene

Gene Ontology (GO) - Biological Process for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF534: view

No data available for SIGNOR curated interactions for ZNF534 Gene

Drugs & Compounds for ZNF534 Gene

No Compound Related Data Available

Transcripts for ZNF534 Gene

mRNA/cDNA for ZNF534 Gene

6 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF534

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF534 Gene

No ASD Table

Relevant External Links for ZNF534 Gene

GeneLoc Exon Structure for
ZNF534

Expression for ZNF534 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF534 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF534 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.6) and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for ZNF534 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.9) and Pancreatic juice (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF534 Gene



Protein tissue co-expression partners for ZNF534 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF534

SOURCE GeneReport for Unigene cluster for ZNF534 Gene:

Hs.447583
genes like me logo Genes that share expression patterns with ZNF534: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF534 Gene

Orthologs for ZNF534 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF534 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF534 30
  • 98.76 (n)
-- 31
  • 85 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 49 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 48 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf484 30
  • 58.8 (n)
Species where no ortholog for ZNF534 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF534 Gene

ENSEMBL:
Gene Tree for ZNF534 (if available)
TreeFam:
Gene Tree for ZNF534 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF534: view image

Paralogs for ZNF534 Gene

Paralogs for ZNF534 Gene

(495) SIMAP similar genes for ZNF534 Gene using alignment to 4 proteins:

  • ZN534_HUMAN
  • Q1T7F5_HUMAN
  • Q1T7F6_HUMAN
  • Q96LN7_HUMAN
genes like me logo Genes that share paralogs with ZNF534: view

Variants for ZNF534 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF534 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs193921143 Uncertain Significance: Malignant tumor of prostate 52,431,487(+) C/A MISSENSE_VARIANT,NONSENSE

Additional dbSNP identifiers (rs#s) for ZNF534 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF534 Gene

Variant ID Type Subtype PubMed ID
dgv1807n106 CNV deletion 24896259
esv1406635 CNV deletion 17803354
esv2314940 CNV deletion 18987734
esv2669061 CNV deletion 23128226
esv2718782 CNV deletion 23290073
esv2718783 CNV deletion 23290073
esv2762048 CNV loss 21179565
esv3556563 CNV deletion 23714750
esv3644693 CNV loss 21293372
esv3893233 CNV loss 25118596
nsv1063648 CNV gain 25217958
nsv1071545 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1150878 CNV deletion 26484159
nsv138393 CNV deletion 16902084
nsv580026 CNV loss 21841781
nsv828615 CNV loss 20364138
nsv833873 CNV gain 17160897
nsv954642 CNV deletion 24416366
nsv960863 CNV duplication 23825009

Variation tolerance for ZNF534 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF534 Gene

Human Gene Mutation Database (HGMD)
ZNF534
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF534

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF534 Gene

Disorders for ZNF534 Gene

No disorders were found for ZNF534 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF534 Gene

Publications for ZNF534 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ZNF534 Gene

Sources for ZNF534 Gene