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Aliases for ZNF534 Gene

Aliases for ZNF534 Gene

  • Zinc Finger Protein 534 2 3 5
  • KRAB Domain Only Protein 3 3 4
  • KRAB Domain Only 3 2 3
  • KRBO3 3 4

External Ids for ZNF534 Gene

Previous HGNC Symbols for ZNF534 Gene

  • KRBO3

Previous GeneCards Identifiers for ZNF534 Gene

  • GC19P057624
  • GC19P057592
  • GC19P052932
  • GC19P049265

Summaries for ZNF534 Gene

GeneCards Summary for ZNF534 Gene

ZNF534 (Zinc Finger Protein 534) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF528.

UniProtKB/Swiss-Prot for ZNF534 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF534 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF534 Gene

Genomics for ZNF534 Gene

GeneHancer (GH) Regulatory Elements for ZNF534 Gene

Promoters and enhancers for ZNF534 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052431 Promoter 0.5 EPDnew 550.8 +2.3 2285 0.1 ZNF534 LOC100419844
GH19I052396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 20.1 -31.4 -31387 2 ELF3 ARID4B KLF5 ZNF48 ZBTB40 YY1 ETS1 ZNF335 CBX5 ZNF366 ZNF528 ZNF528-AS1 ZNF534 ZNF175 ZNF611 LOC100419835
GH19I052452 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 12.6 +24.5 24487 1.5 SP3 NRF1 ELF1 ZBTB40 ZNF518A NR2F2 ETS1 GABPA CBX1 POLR2A ZNF578 GC19P052460 ZNF534 ENSG00000269001 LOC100419836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF534 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF534 gene promoter:

Genomic Locations for ZNF534 Gene

Genomic Locations for ZNF534 Gene
chr19:52,429,187-52,452,315
(GRCh38/hg38)
Size:
23,129 bases
Orientation:
Plus strand
chr19:52,932,440-52,955,568
(GRCh37/hg19)

Genomic View for ZNF534 Gene

Genes around ZNF534 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF534 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF534 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF534 Gene

Proteins for ZNF534 Gene

  • Protein details for ZNF534 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KX8-ZN534_HUMAN
    Recommended name:
    Zinc finger protein 534
    Protein Accession:
    Q76KX8
    Secondary Accessions:
    • Q76KX9

    Protein attributes for ZNF534 Gene

    Size:
    674 amino acids
    Molecular mass:
    77167 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF534 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF534 Gene

Post-translational modifications for ZNF534 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF534 Gene

Domains & Families for ZNF534 Gene

Gene Families for ZNF534 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF534 Gene

Suggested Antigen Peptide Sequences for ZNF534 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KX8

UniProtKB/Swiss-Prot:

ZN534_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF534: view

Function for ZNF534 Gene

Molecular function for ZNF534 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF534: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF534 Gene

Localization for ZNF534 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF534 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF534 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF534: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF534 Gene

Pathways & Interactions for ZNF534 Gene

SuperPathways for ZNF534 Gene

No Data Available

Interacting Proteins for ZNF534 Gene

Gene Ontology (GO) - Biological Process for ZNF534 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF534: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF534 Gene

Drugs & Compounds for ZNF534 Gene

No Compound Related Data Available

Transcripts for ZNF534 Gene

mRNA/cDNA for ZNF534 Gene

(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF534 Gene

No ASD Table

Relevant External Links for ZNF534 Gene

GeneLoc Exon Structure for
ZNF534
ECgene alternative splicing isoforms for
ZNF534

Expression for ZNF534 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF534 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF534 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.6) and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for ZNF534 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.9) and Pancreatic juice (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF534 Gene



Protein tissue co-expression partners for ZNF534 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF534 Gene:

ZNF534

SOURCE GeneReport for Unigene cluster for ZNF534 Gene:

Hs.447583
genes like me logo Genes that share expression patterns with ZNF534: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF534 Gene

Orthologs for ZNF534 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF534 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF534 33
  • 98.76 (n)
-- 34
  • 85 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf484 33
  • 58.8 (n)
Species where no ortholog for ZNF534 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF534 Gene

ENSEMBL:
Gene Tree for ZNF534 (if available)
TreeFam:
Gene Tree for ZNF534 (if available)

Paralogs for ZNF534 Gene

(495) SIMAP similar genes for ZNF534 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF534: view

Variants for ZNF534 Gene

Sequence variations from dbSNP and Humsavar for ZNF534 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193921143 uncertain-significance, Malignant tumor of prostate 52,431,487(+) C/A coding_sequence_variant, missense_variant
rs1000097548 -- 52,433,419(+) T/C intron_variant
rs1000167071 -- 52,448,476(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000344767 -- 52,431,828(+) A/G intron_variant
rs1000501818 -- 52,449,936(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF534 Gene

Variant ID Type Subtype PubMed ID
nsv960863 CNV duplication 23825009
nsv954642 CNV deletion 24416366
nsv833873 CNV gain 17160897
nsv828615 CNV loss 20364138
nsv580026 CNV loss 21841781
nsv138393 CNV deletion 16902084
nsv1150878 CNV deletion 26484159
nsv1140251 OTHER inversion 24896259
nsv1071545 CNV deletion 25765185
nsv1063648 CNV gain 25217958
esv3893233 CNV loss 25118596
esv3644693 CNV loss 21293372
esv3556563 CNV deletion 23714750
esv2762048 CNV loss 21179565
esv2718783 CNV deletion 23290073
esv2718782 CNV deletion 23290073
esv2669061 CNV deletion 23128226
esv2314940 CNV deletion 18987734
esv1406635 CNV deletion 17803354
dgv1807n106 CNV deletion 24896259

Variation tolerance for ZNF534 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF534 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF534

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF534 Gene

Disorders for ZNF534 Gene

Additional Disease Information for ZNF534

No disorders were found for ZNF534 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF534 Gene

Publications for ZNF534 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF534 Gene

Sources for ZNF534 Gene

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