Aliases for ZNF532 Gene

Aliases for ZNF532 Gene

  • Zinc Finger Protein 532 2 3 4 5
  • KIAA1629 4

External Ids for ZNF532 Gene

Previous GeneCards Identifiers for ZNF532 Gene

  • GC18P054680
  • GC18P054678
  • GC18P056529
  • GC18P053238

Summaries for ZNF532 Gene

GeneCards Summary for ZNF532 Gene

ZNF532 (Zinc Finger Protein 532) is a Protein Coding gene. Diseases associated with ZNF532 include Nut Midline Carcinoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF200.

UniProtKB/Swiss-Prot Summary for ZNF532 Gene

Additional gene information for ZNF532 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF532 Gene

Genomics for ZNF532 Gene

GeneHancer (GH) Regulatory Elements for ZNF532 Gene

Promoters and enhancers for ZNF532 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF532 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF532 gene promoter:
  • CREB
  • deltaCREB
  • E2F-1
  • FOXD3
  • FOXL1
  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-5
  • STAT5A

Genomic Locations for ZNF532 Gene

Genomic Locations for ZNF532 Gene
chr18:58,862,600-58,986,480
(GRCh38/hg38)
Size:
123,881 bases
Orientation:
Plus strand
chr18:56,529,832-56,653,712
(GRCh37/hg19)
Size:
123,881 bases
Orientation:
Plus strand

Genomic View for ZNF532 Gene

Genes around ZNF532 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF532 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF532 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF532 Gene

Proteins for ZNF532 Gene

  • Protein details for ZNF532 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE3-ZN532_HUMAN
    Recommended name:
    Zinc finger protein 532
    Protein Accession:
    Q9HCE3
    Secondary Accessions:
    • Q4G0V6
    • Q7L7Z7
    • Q96QR7
    • Q9NVJ6

    Protein attributes for ZNF532 Gene

    Size:
    1301 amino acids
    Molecular mass:
    141696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36366.1; Type=Frameshift; Positions=1077; Evidence={ECO:0000305}; Sequence=BAA91755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB13455.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF532 Gene

Post-translational modifications for ZNF532 Gene

  • Ubiquitination at Lys248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF532 Gene

Domains & Families for ZNF532 Gene

Gene Families for ZNF532 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF532 Gene

Suggested Antigen Peptide Sequences for ZNF532 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 532 (ZN532_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCE3

UniProtKB/Swiss-Prot:

ZN532_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF532: view

Function for ZNF532 Gene

Molecular function for ZNF532 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF532 Gene

Gene Ontology (GO) - Molecular Function for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF532: view
genes like me logo Genes that share phenotypes with ZNF532: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF532

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF532 Gene

Localization for ZNF532 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF532 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF532 gene
Compartment Confidence
nucleus 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF532: view

Pathways & Interactions for ZNF532 Gene

PathCards logo

SuperPathways for ZNF532 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF532: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF532 Gene

Drugs & Compounds for ZNF532 Gene

No Compound Related Data Available

Transcripts for ZNF532 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF532

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF532 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1:
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - -
SP19: - -
SP20: - - -
SP21: -
SP22: - - -
SP23:
SP24:
SP25: - - -

ExUns: 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b · 22c · 22d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21:
SP22: - -
SP23:
SP24:
SP25:

Relevant External Links for ZNF532 Gene

GeneLoc Exon Structure for
ZNF532
ECgene alternative splicing isoforms for
ZNF532

Expression for ZNF532 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF532 Gene

Protein differential expression in normal tissues from HIPED for ZNF532 Gene

This gene is overexpressed in Lung (28.1), Plasma (22.1), Heart (8.8), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF532 Gene



Protein tissue co-expression partners for ZNF532 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF532 Gene:

ZNF532

SOURCE GeneReport for Unigene cluster for ZNF532 Gene:

Hs.529023

Evidence on tissue expression from TISSUES for ZNF532 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF532: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF532 Gene

Orthologs for ZNF532 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF532 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455444 32
  • 99.4 (n)
ZNF532 33
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp532 33
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF532 33
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF532 33
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF532 33 32
  • 88.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp532 32
  • 87.47 (n)
cow
(Bos Taurus)
Mammalia ZNF532 33 32
  • 83.29 (n)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 93 (a)
OneToMany
-- 33
  • 88 (a)
OneToMany
-- 33
  • 82 (a)
OneToMany
LOC100857356 32
  • 80.96 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF532 33
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf532 32
  • 70.82 (n)
Str.18390 32
zebrafish
(Danio rerio)
Actinopterygii znf532 33 32
  • 65.18 (n)
OneToOne
Dr.11710 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 27 (a)
OneToMany
Species where no ortholog for ZNF532 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF532 Gene

ENSEMBL:
Gene Tree for ZNF532 (if available)
TreeFam:
Gene Tree for ZNF532 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF532: view image

Paralogs for ZNF532 Gene

Paralogs for ZNF532 Gene

(4) SIMAP similar genes for ZNF532 Gene using alignment to 15 proteins:

  • ZN532_HUMAN
  • K7EIU3_HUMAN
  • K7EJM2_HUMAN
  • K7EKV7_HUMAN
  • K7EL14_HUMAN
  • K7ELB7_HUMAN
  • K7ELQ2_HUMAN
  • K7EMF9_HUMAN
  • K7EN67_HUMAN
  • K7EP49_HUMAN
  • K7EPI7_HUMAN
  • K7EQN0_HUMAN
  • K7EQW7_HUMAN
  • K7ER18_HUMAN
  • K7ES47_HUMAN
genes like me logo Genes that share paralogs with ZNF532: view

Variants for ZNF532 Gene

Sequence variations from dbSNP and Humsavar for ZNF532 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs771503724 A breast cancer sample 58,934,551(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000069462 -- 58,973,352(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000096945 -- 58,886,777(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000108272 -- 58,968,082(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000113959 -- 58,930,360(+) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF532 Gene

Variant ID Type Subtype PubMed ID
esv1419346 CNV insertion 17803354
esv28415 CNV loss 19812545
esv3410830 CNV duplication 20981092
esv3642655 CNV loss 21293372
nsv1072269 CNV deletion 25765185
nsv1126486 CNV deletion 24896259
nsv2325 CNV insertion 18451855
nsv2326 CNV deletion 18451855
nsv833664 CNV loss 17160897
nsv960282 CNV duplication 23825009
nsv960283 CNV duplication 23825009
nsv960284 CNV duplication 23825009

Variation tolerance for ZNF532 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF532 Gene

Human Gene Mutation Database (HGMD)
ZNF532
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF532

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF532 Gene

Disorders for ZNF532 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF532 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF532

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF532: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF532 Gene

Publications for ZNF532 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56

Products for ZNF532 Gene

Sources for ZNF532 Gene