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ZNF528 (Zinc Finger Protein 528) is a Protein Coding gene. Diseases associated with ZNF528 include Spiradenoma and Apocrine Sweat Gland Neoplasm. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF880.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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2 | Herpes simplex virus 1 infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF528 30 |
|
||
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.921 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs116544786 | Benign: not provided | 52,415,911(+) |
C/G NM_032423.3(ZNF528):c.1059C>G (p.Tyr353Ter) |
NONSENSE | |
rs141013163 | Likely Benign: not provided | 52,405,974(+) |
C/T NM_032423.3(ZNF528):c.83C>T (p.Ala28Val) |
MISSENSE | |
rs146381631 | Benign: not provided | 52,416,371(+) |
A/T NM_032423.3(ZNF528):c.1519A>T (p.Asn507Tyr) |
MISSENSE | |
rs150257846 | Likely Benign: not provided | 52,416,134(+) |
C/T NM_032423.3(ZNF528):c.1282C>T (p.Arg428Ter) |
NONSENSE | |
rs562901913 | Likely Benign: not provided | 52,415,231(+) |
AG/A NM_032423.3(ZNF528):c.381del (p.Ile129fs) |
FRAMESHIFT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762048 | CNV | loss | 21179565 |
esv33518 | CNV | gain | 17666407 |
esv3644693 | CNV | loss | 21293372 |
esv3644695 | CNV | loss | 21293372 |
nsv1114029 | CNV | deletion | 24896259 |
nsv1138724 | CNV | deletion | 24896259 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv2536 | CNV | deletion | 18451855 |
nsv521079 | CNV | loss | 19592680 |
nsv828615 | CNV | loss | 20364138 |
nsv833873 | CNV | gain | 17160897 |
nsv978840 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
spiradenoma |
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|
apocrine sweat gland neoplasm |
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|
tetralogy of fallot |
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