Aliases for ZNF526 Gene

Aliases for ZNF526 Gene

  • Zinc Finger Protein 526 2 3 4 5
  • KIAA1951 4

External Ids for ZNF526 Gene

Previous GeneCards Identifiers for ZNF526 Gene

  • GC19P047416
  • GC19P042724
  • GC19P039154

Summaries for ZNF526 Gene

GeneCards Summary for ZNF526 Gene

ZNF526 (Zinc Finger Protein 526) is a Protein Coding gene. Diseases associated with ZNF526 include Prostate Small Cell Carcinoma and Autosomal Dominant Non-Syndromic Intellectual Disability 4. An important paralog of this gene is ZNF574.

UniProtKB/Swiss-Prot Summary for ZNF526 Gene

Additional gene information for ZNF526 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF526 Gene

Genomics for ZNF526 Gene

GeneHancer (GH) Regulatory Elements for ZNF526 Gene

Promoters and enhancers for ZNF526 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF526 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF526

Top Transcription factor binding sites by QIAGEN in the ZNF526 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPbeta
  • E47
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Tal-1

Genomic Locations for ZNF526 Gene

Genomic Locations for ZNF526 Gene
chr19:42,220,312-42,228,201
(GRCh38/hg38)
Size:
7,890 bases
Orientation:
Plus strand
chr19:42,724,423-42,732,353
(GRCh37/hg19)
Size:
7,931 bases
Orientation:
Plus strand

Genomic View for ZNF526 Gene

Genes around ZNF526 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF526 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF526 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF526 Gene

Proteins for ZNF526 Gene

  • Protein details for ZNF526 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF50-ZN526_HUMAN
    Recommended name:
    Zinc finger protein 526
    Protein Accession:
    Q8TF50
    Secondary Accessions:
    • B3KV29
    • Q69YI2
    • Q96E24

    Protein attributes for ZNF526 Gene

    Size:
    670 amino acids
    Molecular mass:
    73622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85537.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF526 Gene

Post-translational modifications for ZNF526 Gene

  • Ubiquitination at Lys570
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF526 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF526 Gene

Domains & Families for ZNF526 Gene

Gene Families for ZNF526 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF526 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF526 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51279, highly similar to Homo sapiens zinc finger protein 526 (ZNF526), mRNA (B4DQP4_HUMAN)
  • Zinc finger protein 526 (ZN526_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF50

UniProtKB/Swiss-Prot:

ZN526_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF526: view

Function for ZNF526 Gene

Molecular function for ZNF526 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF526 Gene

Gene Ontology (GO) - Molecular Function for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF526: view
genes like me logo Genes that share phenotypes with ZNF526: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF526

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF526 Gene

Localization for ZNF526 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF526 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF526 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF526: view

Pathways & Interactions for ZNF526 Gene

PathCards logo

SuperPathways for ZNF526 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF526 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF526 Gene

Drugs & Compounds for ZNF526 Gene

No Compound Related Data Available

Transcripts for ZNF526 Gene

mRNA/cDNA for ZNF526 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF526

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF526 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ZNF526 Gene

GeneLoc Exon Structure for
ZNF526

Expression for ZNF526 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF526 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF526 Gene

This gene is overexpressed in Urinary Bladder (36.8) and Fetal ovary (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF526 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF526

SOURCE GeneReport for Unigene cluster for ZNF526 Gene:

Hs.137282

Evidence on tissue expression from TISSUES for ZNF526 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF526: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF526 Gene

Orthologs for ZNF526 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF526 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF526 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF526 31 30
  • 85.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF526 31 30
  • 84.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp526 17 31 30
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp526 30
  • 82.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF526 31
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 20 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8424 30
zebrafish
(Danio rerio)
Actinopterygii znf526 31
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 31
  • 10 (a)
OneToMany
Species where no ortholog for ZNF526 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF526 Gene

ENSEMBL:
Gene Tree for ZNF526 (if available)
TreeFam:
Gene Tree for ZNF526 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF526: view image

Paralogs for ZNF526 Gene

(7) SIMAP similar genes for ZNF526 Gene using alignment to 3 proteins:

  • ZN526_HUMAN
  • H9ZYJ3_HUMAN
  • M0R395_HUMAN
genes like me logo Genes that share paralogs with ZNF526: view

Variants for ZNF526 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF526 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1021674497 Uncertain Significance: not specified 42,224,402(+) C/T FIVE_PRIME_UTR_VARIANT
rs111722832 Benign: not specified; not provided 42,226,065(+) C/T SYNONYMOUS_VARIANT
rs1207022095 Likely Benign: not specified 42,225,397(+) C/T MISSENSE_VARIANT
rs138082392 Uncertain Significance: not specified 42,225,228(+) C/T SYNONYMOUS_VARIANT
rs143303371 Uncertain Significance: not specified 42,226,384(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF526 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF526 Gene

Variant ID Type Subtype PubMed ID
nsv1139703 CNV duplication 24896259
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833833 CNV loss 17160897

Variation tolerance for ZNF526 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF526 Gene

Human Gene Mutation Database (HGMD)
ZNF526
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF526

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF526 Gene

Disorders for ZNF526 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZNF526 Gene - From: DISEASES and GeneCards

Additional Disease Information for ZNF526

genes like me logo Genes that share disorders with ZNF526: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF526 Gene

Publications for ZNF526 Gene

No publications were found for ZNF526 Gene.

Products for ZNF526 Gene

Sources for ZNF526 Gene