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Aliases for ZNF526 Gene

Aliases for ZNF526 Gene

  • Zinc Finger Protein 526 2 3 4 5
  • KIAA1951 4

External Ids for ZNF526 Gene

Previous GeneCards Identifiers for ZNF526 Gene

  • GC19P047416
  • GC19P042724
  • GC19P039154

Summaries for ZNF526 Gene

GeneCards Summary for ZNF526 Gene

ZNF526 (Zinc Finger Protein 526) is a Protein Coding gene. Diseases associated with ZNF526 include Pulmonic Stenosis. An important paralog of this gene is ZNF574.

UniProtKB/Swiss-Prot for ZNF526 Gene

Additional gene information for ZNF526 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF526 Gene

Genomics for ZNF526 Gene

GeneHancer (GH) Regulatory Elements for ZNF526 Gene

Promoters and enhancers for ZNF526 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042215 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 622.7 -1.6 -1575 5.8 SP1 CC2D1A ZFX ELF3 MNT ZNF148 NKRF POLR2A MLLT1 CEBPG ZNF526 POU2F2 DEDD2 ZNF574 GSK3A HNRNPUL1 CIC
GH19J041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 147.3 -916.8 -916824 17.1 SP1 ZFX CTCF ELF3 MNT SIX5 ZNF148 NKRF POLR2A MLLT1 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 ITPKC TMEM91
GH19J041882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 105.8 -333.6 -333612 9.2 SP1 ZFX ELF3 SIX5 NKRF POLR2A MLLT1 ZNF121 RERE GTF2F1 ARHGEF1 ZNF526 HNRNPUL1 CCDC97 ZNF574 RPS19 RABAC1 MEGF8 AXL CIC
GH19J042267 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 89.8 +50.6 50599 6.9 SP1 ZNF652 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF MLLT1 CIC PIR59110 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PRR19 PAFAH1B3
GH19J041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 89.3 -868.7 -868658 6.9 SP1 ZFX CC2D1A CTCF CBFA2T2 ZNF148 NKRF MLLT1 POLR2A GTF2F1 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 CCDC97 ENSG00000269843 COQ8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF526 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF526 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPbeta
  • E47
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Tal-1

Genomic Locations for ZNF526 Gene

Genomic Locations for ZNF526 Gene
chr19:42,220,271-42,228,201
(GRCh38/hg38)
Size:
7,931 bases
Orientation:
Plus strand
chr19:42,724,423-42,732,353
(GRCh37/hg19)
Size:
7,931 bases
Orientation:
Plus strand

Genomic View for ZNF526 Gene

Genes around ZNF526 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF526 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF526 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF526 Gene

Proteins for ZNF526 Gene

  • Protein details for ZNF526 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF50-ZN526_HUMAN
    Recommended name:
    Zinc finger protein 526
    Protein Accession:
    Q8TF50
    Secondary Accessions:
    • B3KV29
    • Q69YI2
    • Q96E24

    Protein attributes for ZNF526 Gene

    Size:
    670 amino acids
    Molecular mass:
    73622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85537.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF526 Gene

Post-translational modifications for ZNF526 Gene

  • Ubiquitination at posLast=570570
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF526 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF526 Gene

Domains & Families for ZNF526 Gene

Gene Families for ZNF526 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF526 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF526 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51279, highly similar to Homo sapiens zinc finger protein 526 (ZNF526), mRNA (B4DQP4_HUMAN)
  • Zinc finger protein 526 (ZN526_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF50

UniProtKB/Swiss-Prot:

ZN526_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF526: view

Function for ZNF526 Gene

Molecular function for ZNF526 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF526 Gene

Gene Ontology (GO) - Molecular Function for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF526: view
genes like me logo Genes that share phenotypes with ZNF526: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF526

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF526 Gene

Localization for ZNF526 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF526 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF526 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF526: view

Pathways & Interactions for ZNF526 Gene

PathCards logo

SuperPathways for ZNF526 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF526: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF526 Gene

Drugs & Compounds for ZNF526 Gene

No Compound Related Data Available

Transcripts for ZNF526 Gene

mRNA/cDNA for ZNF526 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(91) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF526 Gene

Zinc finger protein 526:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF526

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF526 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ZNF526 Gene

GeneLoc Exon Structure for
ZNF526
ECgene alternative splicing isoforms for
ZNF526

Expression for ZNF526 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF526 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF526 Gene

This gene is overexpressed in Urinary Bladder (36.8) and Fetal ovary (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF526 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF526 Gene:

ZNF526

SOURCE GeneReport for Unigene cluster for ZNF526 Gene:

Hs.137282

Evidence on tissue expression from TISSUES for ZNF526 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF526: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF526 Gene

Orthologs for ZNF526 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF526 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF526 35 34
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF526 35 34
  • 85.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF526 35 34
  • 84.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp526 17 35 34
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp526 34
  • 82.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF526 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8424 34
zebrafish
(Danio rerio)
Actinopterygii znf526 35
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 35
  • 10 (a)
OneToMany
Species where no ortholog for ZNF526 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF526 Gene

ENSEMBL:
Gene Tree for ZNF526 (if available)
TreeFam:
Gene Tree for ZNF526 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF526: view image

Paralogs for ZNF526 Gene

(7) SIMAP similar genes for ZNF526 Gene using alignment to 3 proteins:

  • ZN526_HUMAN
  • H9ZYJ3_HUMAN
  • M0R395_HUMAN
genes like me logo Genes that share paralogs with ZNF526: view

Variants for ZNF526 Gene

Sequence variations from dbSNP and Humsavar for ZNF526 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs3810151 likely-benign, not specified, - 42,224,684(+) T/C coding_sequence_variant, missense_variant
rs730882205 likely-pathogenic, Intellectual disability, Noonan-like facies, Pulmonic stenosis, not provided 42,224,882(+) A/C coding_sequence_variant, missense_variant
rs111722832 likely-benign, not specified 42,226,065(+) C/T coding_sequence_variant, synonymous_variant
rs1207022095 likely-benign, not specified 42,225,397(+) C/T coding_sequence_variant, missense_variant
rs145696319 likely-benign, not specified 42,225,861(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF526 Gene

Variant ID Type Subtype PubMed ID
nsv1139703 CNV duplication 24896259
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833833 CNV loss 17160897

Variation tolerance for ZNF526 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF526 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF526
Human Gene Mutation Database (HGMD)
ZNF526

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF526 Gene

Disorders for ZNF526 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF526 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
pulmonic stenosis
  • pulmonary valve stenosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF526

genes like me logo Genes that share disorders with ZNF526: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF526 Gene

Publications for ZNF526 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for ZNF526 Gene

Sources for ZNF526 Gene

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