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Aliases for ZNF526 Gene

Aliases for ZNF526 Gene

  • Zinc Finger Protein 526 2 3 5
  • KIAA1951 4

External Ids for ZNF526 Gene

Previous GeneCards Identifiers for ZNF526 Gene

  • GC19P047416
  • GC19P042724
  • GC19P039154

Summaries for ZNF526 Gene

GeneCards Summary for ZNF526 Gene

ZNF526 (Zinc Finger Protein 526) is a Protein Coding gene. An important paralog of this gene is ZNF574.

UniProtKB/Swiss-Prot for ZNF526 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF526 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF526 Gene

Genomics for ZNF526 Gene

GeneHancer (GH) Regulatory Elements for ZNF526 Gene

Promoters and enhancers for ZNF526 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I042215 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.6 -1.7 -1656 5.6 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC PPARGC1A ZNF526 DEDD2 ZNF574 GSK3A POU2F2 CIC
GH19I041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 157.3 -917.0 -916974 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 AXL ITPKC
GH19I041261 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 88.5 -955.4 -955421 7.3 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D HNRNPUL1 ZNF526 ZNF574 CCDC97 SNRPA ENSG00000269843 CYP2F2P NUMBL ITPKC SPTBN4
GH19I042276 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 80 +61.6 61642 11.1 YBX1 E2F8 ZNF416 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 GLIS1 CIC ZNF526 ZNF574 CCDC97 MEGF8 GRIK5 DEDD2 CEACAM8 PAFAH1B3 TMEM145
GH19I041882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 93.7 -333.6 -333612 9.2 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ARHGEF1 ZNF526 HNRNPUL1 CCDC97 ZNF574 RPS19 RABAC1 CYP2G1P MEGF8 AXL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF526 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF526 gene promoter:

Genomic Locations for ZNF526 Gene

Genomic Locations for ZNF526 Gene
chr19:42,220,271-42,228,201
(GRCh38/hg38)
Size:
7,931 bases
Orientation:
Plus strand
chr19:42,724,423-42,732,353
(GRCh37/hg19)

Genomic View for ZNF526 Gene

Genes around ZNF526 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF526 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF526 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF526 Gene

Proteins for ZNF526 Gene

  • Protein details for ZNF526 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF50-ZN526_HUMAN
    Recommended name:
    Zinc finger protein 526
    Protein Accession:
    Q8TF50
    Secondary Accessions:
    • B3KV29
    • Q69YI2
    • Q96E24

    Protein attributes for ZNF526 Gene

    Size:
    670 amino acids
    Molecular mass:
    73622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85537.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF526 Gene

Post-translational modifications for ZNF526 Gene

  • Ubiquitination at isoforms=570
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF526 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF526 Gene

Domains & Families for ZNF526 Gene

Gene Families for ZNF526 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF526 Gene

Suggested Antigen Peptide Sequences for ZNF526 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF50

UniProtKB/Swiss-Prot:

ZN526_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF526: view

Function for ZNF526 Gene

Molecular function for ZNF526 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF526 Gene

Gene Ontology (GO) - Molecular Function for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF526: view
genes like me logo Genes that share phenotypes with ZNF526: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF526 Gene

Localization for ZNF526 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF526 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF526 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF526: view

Pathways & Interactions for ZNF526 Gene

SuperPathways for ZNF526 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF526 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF526: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF526 Gene

Drugs & Compounds for ZNF526 Gene

No Compound Related Data Available

Transcripts for ZNF526 Gene

mRNA/cDNA for ZNF526 Gene

Unigene Clusters for ZNF526 Gene

Zinc finger protein 526:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF526 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ZNF526 Gene

GeneLoc Exon Structure for
ZNF526
ECgene alternative splicing isoforms for
ZNF526

Expression for ZNF526 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF526 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF526 Gene

This gene is overexpressed in Urinary Bladder (36.8) and Fetal ovary (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF526 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF526 Gene:

ZNF526

SOURCE GeneReport for Unigene cluster for ZNF526 Gene:

Hs.137282

Evidence on tissue expression from TISSUES for ZNF526 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF526: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF526 Gene

Orthologs for ZNF526 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF526 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF526 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ZNF526 33 34
  • 85.22 (n)
cow
(Bos Taurus)
Mammalia ZNF526 33 34
  • 84.74 (n)
mouse
(Mus musculus)
Mammalia Zfp526 33 16 34
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp526 33
  • 82.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF526 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8424 33
zebrafish
(Danio rerio)
Actinopterygii znf526 34
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 34
  • 10 (a)
OneToMany
Species where no ortholog for ZNF526 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF526 Gene

ENSEMBL:
Gene Tree for ZNF526 (if available)
TreeFam:
Gene Tree for ZNF526 (if available)

Paralogs for ZNF526 Gene

Paralogs for ZNF526 Gene

(7) SIMAP similar genes for ZNF526 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF526: view

Variants for ZNF526 Gene

Sequence variations from dbSNP and Humsavar for ZNF526 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs730882205 likely-pathogenic, Intellectual disability, Noonan-like facies, Pulmonic stenosis, not provided 42,224,882(+) A/C coding_sequence_variant, missense_variant
rs111722832 likely-benign, not specified 42,226,065(+) C/T coding_sequence_variant, synonymous_variant
rs145696319 likely-benign, not specified 42,225,861(+) C/T coding_sequence_variant, synonymous_variant
rs3810151 likely-benign, not specified 42,224,684(+) T/C coding_sequence_variant, missense_variant
rs57984044 likely-benign, not specified 42,224,904(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF526 Gene

Variant ID Type Subtype PubMed ID
nsv1139703 CNV duplication 24896259
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833833 CNV loss 17160897

Variation tolerance for ZNF526 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF526 Gene

Human Gene Mutation Database (HGMD)
ZNF526
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF526

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF526 Gene

Disorders for ZNF526 Gene

Additional Disease Information for ZNF526

No disorders were found for ZNF526 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF526 Gene

Publications for ZNF526 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF526 Gene

Sources for ZNF526 Gene

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