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Aliases for ZNF525 Gene

Aliases for ZNF525 Gene

  • Zinc Finger Protein 525 2 3 5
  • KIAA1979 4

External Ids for ZNF525 Gene

Previous GeneCards Identifiers for ZNF525 Gene

  • GC19U900025
  • GC19P058524
  • GC19P058570
  • GC19P053870
  • GC19P050189
  • GC19P053330

Summaries for ZNF525 Gene

GeneCards Summary for ZNF525 Gene

ZNF525 (Zinc Finger Protein 525) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and structural constituent of ribosome. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot for ZNF525 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF525 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF525 Gene

Genomics for ZNF525 Gene

GeneHancer (GH) Regulatory Elements for ZNF525 Gene

Promoters and enhancers for ZNF525 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053364 Promoter/Enhancer 1.4 Ensembl ENCODE 572.6 +0.2 152 1.9 HDAC1 ELF3 SMAD1 RB1 ARID4B SIN3A GLI4 ZBTB40 RAD21 ZNF335 ZNF525 VN1R2 ZNF677 PIR40972
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.2 +840.0 840017 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I053977 Promoter/Enhancer 1.7 Ensembl ENCODE 43.9 +614.3 614269 5.8 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 ZNF766 ZNF213 ZNF143 SP3 PRPF31 ZNF525 LENG8-AS1 ZNF160 ZNF845 ZNF665 ZNF761 ZNF347 LENG8 ENSG00000235681
GH19I053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 33.6 +153.9 153921 4.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 KLF13 ZNF331 ZNF137P LENG8 ZNF525 LENG8-AS1 PRPF31 CNOT3 ZNF160 ZNF701 ZNF83
GH19I052733 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 21.4 -630.5 -630450 2.9 HDGF SMAD1 ARID4B SIN3A ZNF48 POLR2B E2F8 ARID2 ATF7 SP3 ZNF611 ZNF701 ZNF137P ENSG00000268970 ENSG00000269001 ZNF845 ZNF808 ZNF160 ZNF525 ZNF816
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF525 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF525 gene promoter:

Genomic Locations for ZNF525 Gene

Genomic Locations for ZNF525 Gene
chr19:53,365,693-53,392,217
(GRCh38/hg38)
Size:
26,525 bases
Orientation:
Plus strand
chr19:53,868,946-53,895,470
(GRCh37/hg19)

Genomic View for ZNF525 Gene

Genes around ZNF525 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF525 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF525 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF525 Gene

Proteins for ZNF525 Gene

  • Protein details for ZNF525 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N782-ZN525_HUMAN
    Recommended name:
    Zinc finger protein 525
    Protein Accession:
    Q8N782
    Secondary Accessions:
    • Q8TF23

    Protein attributes for ZNF525 Gene

    Size:
    197 amino acids
    Molecular mass:
    23070 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85565.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAC05417.1; Type=Frameshift; Positions=103; Evidence={ECO:0000305};

neXtProt entry for ZNF525 Gene

Post-translational modifications for ZNF525 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF525 Gene

No data available for DME Specific Peptides for ZNF525 Gene

Domains & Families for ZNF525 Gene

Gene Families for ZNF525 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF525 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF525 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N782

UniProtKB/Swiss-Prot:

ZN525_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF525: view

Function for ZNF525 Gene

Molecular function for ZNF525 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF525 Gene

Gene Ontology (GO) - Molecular Function for ZNF525 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF525: view
genes like me logo Genes that share phenotypes with ZNF525: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF525 Gene

Localization for ZNF525 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF525 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF525 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF525 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF525: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF525 Gene

Pathways & Interactions for ZNF525 Gene

SuperPathways for ZNF525 Gene

No Data Available

Interacting Proteins for ZNF525 Gene

Gene Ontology (GO) - Biological Process for ZNF525 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF525: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF525 Gene

Drugs & Compounds for ZNF525 Gene

No Compound Related Data Available

Transcripts for ZNF525 Gene

mRNA/cDNA for ZNF525 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF525 Gene

Zinc finger protein 525:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF525 Gene

No ASD Table

Relevant External Links for ZNF525 Gene

GeneLoc Exon Structure for
ZNF525
ECgene alternative splicing isoforms for
ZNF525

Expression for ZNF525 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF525 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF525 Gene:

ZNF525

SOURCE GeneReport for Unigene cluster for ZNF525 Gene:

Hs.352638

Evidence on tissue expression from TISSUES for ZNF525 Gene

  • Nervous system(4.2)
  • Thyroid gland(4.1)
  • Pancreas(2.6)
genes like me logo Genes that share expression patterns with ZNF525: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF525 Gene

Orthologs for ZNF525 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF525 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF525 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
ManyToMany
Species where no ortholog for ZNF525 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF525 Gene

ENSEMBL:
Gene Tree for ZNF525 (if available)
TreeFam:
Gene Tree for ZNF525 (if available)

Paralogs for ZNF525 Gene

(543) SIMAP similar genes for ZNF525 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF525 Gene

genes like me logo Genes that share paralogs with ZNF525: view

Variants for ZNF525 Gene

Sequence variations from dbSNP and Humsavar for ZNF525 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000501860 -- 53,383,941(+) C/T non_coding_transcript_variant
rs1000552464 -- 53,384,235(+) G/A non_coding_transcript_variant
rs1000804240 -- 53,378,771(+) G/A intron_variant
rs1000819338 -- 53,386,302(+) C/A non_coding_transcript_variant
rs1001036792 -- 53,373,085(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF525 Gene

Variant ID Type Subtype PubMed ID
dgv3646n100 CNV loss 25217958
dgv530e201 CNV deletion 23290073
dgv6535n54 CNV gain 21841781
esv2368045 CNV deletion 18987734
esv2462032 CNV deletion 19546169
esv2659102 CNV deletion 23128226
esv2670793 CNV deletion 23128226
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2718819 CNV deletion 23290073
esv2718821 CNV deletion 23290073
esv3556587 CNV deletion 23714750
esv3574764 CNV gain 25503493
esv3644752 CNV gain 21293372
esv8848 CNV loss 19470904
nsv1055773 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv458767 CNV loss 19166990
nsv512593 CNV loss 21212237
nsv521988 CNV loss 19592680
nsv527524 CNV loss 19592680
nsv580082 CNV loss 21841781
nsv978846 CNV duplication 23825009

Variation tolerance for ZNF525 Gene

Gene Damage Index Score: 0.66; 14.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF525 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF525

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF525 Gene

Disorders for ZNF525 Gene

Additional Disease Information for ZNF525

No disorders were found for ZNF525 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF525 Gene

Publications for ZNF525 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF525 Gene

Sources for ZNF525 Gene

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