ZNF524 Gene (Protein Coding)

Zinc Finger Protein 524

GC19P055600
GIFtS:
30
See more...

Aliases for ZNF524 Gene

Aliases for ZNF524 Gene

  • Zinc Finger Protein 524 2 3 4 5
  • MGC23143 2
  • ZNF524 5

External Ids for ZNF524 Gene

Previous GeneCards Identifiers for ZNF524 Gene

  • GC19P060805
  • GC19P060791
  • GC19P056111
  • GC19P052423

Summaries for ZNF524 Gene

GeneCards Summary for ZNF524 Gene

ZNF524 (Zinc Finger Protein 524) is a Protein Coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot Summary for ZNF524 Gene

Additional gene information for ZNF524 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF524 Gene

Genomics for ZNF524 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF524 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF524 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF524

Top Transcription factor binding sites by QIAGEN in the ZNF524 gene promoter:
  • ATF6
  • E2F
  • E2F-1
  • MAZR
  • NF-kappaB
  • NF-kappaB1
  • p53
  • Pax-5
  • Pax-6
  • Spz1

Genomic Locations for ZNF524 Gene

Genomic Locations for ZNF524 Gene
chr19:55,599,772-55,603,138
(GRCh38/hg38)
Size:
3,367 bases
Orientation:
Plus strand
chr19:56,111,388-56,114,504
(GRCh37/hg19)
Size:
3,117 bases
Orientation:
Plus strand

Genomic View for ZNF524 Gene

Genes around ZNF524 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF524 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF524 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF524 Gene

Proteins for ZNF524 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF524 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C55-ZN524_HUMAN
    Recommended name:
    Zinc finger protein 524
    Protein Accession:
    Q96C55
    Secondary Accessions:
    • Q6NW31
    • Q96IL7

    Protein attributes for ZNF524 Gene

    Size:
    264 amino acids
    Molecular mass:
    28709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF524 Gene

Protein Expression for ZNF524 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF524 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF524 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF524 Gene

Domains & Families for ZNF524 Gene

Gene Families for ZNF524 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF524 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF524 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 524 (ZN524_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96C55

UniProtKB/Swiss-Prot:

ZN524_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF524: view

Function for ZNF524 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF524 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF524 Gene

Gene Ontology (GO) - Molecular Function for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF524: view
genes like me logo Genes that share phenotypes with ZNF524: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF524

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF524 Gene

Localization for ZNF524 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF524 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF524 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF524: view

Pathways & Interactions for ZNF524 Gene

PathCards logo

SuperPathways for ZNF524 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF524: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF524 Gene

Drugs & Compounds for ZNF524 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF524 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF524 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF524

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF524 Gene

No ASD Table

Relevant External Links for ZNF524 Gene

GeneLoc Exon Structure for
ZNF524

Expression for ZNF524 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF524 Gene

mRNA expression in normal human tissues for ZNF524 Gene

Protein differential expression in normal tissues from HIPED for ZNF524 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF524 Gene



Protein tissue co-expression partners for ZNF524 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF524

SOURCE GeneReport for Unigene cluster for ZNF524 Gene:

Hs.440291

Evidence on tissue expression from TISSUES for ZNF524 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF524: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF524 Gene

Orthologs for ZNF524 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF524 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF524 30 31
  • 99.12 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZNF524 30 31
  • 91.06 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZNF524 30
  • 87.6 (n)
Rat
(Rattus norvegicus)
 Mammalia Zfp524 30
  • 82.22 (n)
Mouse
(Mus musculus)
 Mammalia Zfp524 30 17 31
  • 81.53 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 14 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 31 (a)
 OneToMany
-- 31
  • 19 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii ZNF581 31
  • 13 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Lin29 31
  • 5 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
OneToOne
Species where no ortholog for ZNF524 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF524 Gene

ENSEMBL:
Gene Tree for ZNF524 (if available)
TreeFam:
Gene Tree for ZNF524 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF524: view image

Paralogs for ZNF524 Gene

Paralogs for ZNF524 Gene

(12) SIMAP similar genes for ZNF524 Gene using alignment to 2 proteins:

  • ZN524_HUMAN
  • K7EP10_HUMAN
genes like me logo Genes that share paralogs with ZNF524: view

Variants for ZNF524 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for ZNF524 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF524 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF524 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF524 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF524

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF524 Gene

Disorders for ZNF524 Gene

Additional Disease Information for ZNF524

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF524 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF524 Gene

Publications for ZNF524 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3

ExternalLinks

View latest publications for ZNF524 gene in Mastermind

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