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Aliases for ZNF524 Gene

Aliases for ZNF524 Gene

  • Zinc Finger Protein 524 2 3 5

External Ids for ZNF524 Gene

Previous GeneCards Identifiers for ZNF524 Gene

  • GC19P060805
  • GC19P060791
  • GC19P056111
  • GC19P052423

Summaries for ZNF524 Gene

GeneCards Summary for ZNF524 Gene

ZNF524 (Zinc Finger Protein 524) is a Protein Coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot for ZNF524 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF524 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF524 Gene

Genomics for ZNF524 Gene

GeneHancer (GH) Regulatory Elements for ZNF524 Gene

Promoters and enhancers for ZNF524 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055598 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.1 +0.5 529 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZBTB7B FIZ1 ZNF524 U2AF2 ZNF471 ZFP28 ZNF470 ZNF582 ENSG00000267523 ZNF581 ZNF580
GH19I055597 Promoter 0.5 EPDnew 550.8 -1.8 -1808 0.1 FIZ1 ZNF524 ZNF579
GH19I055599 Enhancer 0.4 ENCODE 550.8 -1.5 -1455 0.2 ZFHX2 EGR2 ZNF524 FIZ1 ZNF579
GH19I055623 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.2 +24.7 24705 2 HDGF SMAD1 ATF1 ZNF133 SIN3A YY1 POLR2B ZNF143 ATF7 KLF13 ZNF784 ENSG00000267523 U2AF2 ENSG00000267096 ZNF524 FIZ1 ZNF581 ZNF628 TMEM86B ZNF580
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.7 -79.5 -79546 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF524 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF524 gene promoter:

Genomic Locations for ZNF524 Gene

Genomic Locations for ZNF524 Gene
3,384 bases
Plus strand

Genomic View for ZNF524 Gene

Genes around ZNF524 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF524 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF524 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF524 Gene

Proteins for ZNF524 Gene

  • Protein details for ZNF524 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 524
    Protein Accession:
    Secondary Accessions:
    • Q6NW31
    • Q96IL7

    Protein attributes for ZNF524 Gene

    264 amino acids
    Molecular mass:
    28709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF524 Gene

Post-translational modifications for ZNF524 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF524 Gene

No data available for DME Specific Peptides for ZNF524 Gene

Domains & Families for ZNF524 Gene

Gene Families for ZNF524 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF524 Gene


Suggested Antigen Peptide Sequences for ZNF524 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF524: view

Function for ZNF524 Gene

Molecular function for ZNF524 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF524 Gene

Gene Ontology (GO) - Molecular Function for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF524: view
genes like me logo Genes that share phenotypes with ZNF524: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF524 Gene

Localization for ZNF524 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF524 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF524 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF524: view

Pathways & Interactions for ZNF524 Gene

SuperPathways for ZNF524 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF524: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF524 Gene

Drugs & Compounds for ZNF524 Gene

No Compound Related Data Available

Transcripts for ZNF524 Gene

mRNA/cDNA for ZNF524 Gene

Unigene Clusters for ZNF524 Gene

Zinc finger protein 524:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF524 Gene

No ASD Table

Relevant External Links for ZNF524 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF524 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF524 Gene

mRNA expression in normal human tissues for ZNF524 Gene

Protein differential expression in normal tissues from HIPED for ZNF524 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF524 Gene

Protein tissue co-expression partners for ZNF524 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF524 Gene:


SOURCE GeneReport for Unigene cluster for ZNF524 Gene:


Evidence on tissue expression from TISSUES for ZNF524 Gene

  • Intestine(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF524: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF524 Gene

Orthologs for ZNF524 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF524 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF524 33 34
  • 99.12 (n)
(Canis familiaris)
Mammalia ZNF524 33 34
  • 91.06 (n)
(Bos Taurus)
Mammalia ZNF524 33
  • 87.6 (n)
(Rattus norvegicus)
Mammalia Zfp524 33
  • 82.22 (n)
(Mus musculus)
Mammalia Zfp524 33 16 34
  • 81.53 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
-- 34
  • 19 (a)
(Danio rerio)
Actinopterygii ZNF581 34
  • 13 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lin29 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
Species where no ortholog for ZNF524 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF524 Gene

Gene Tree for ZNF524 (if available)
Gene Tree for ZNF524 (if available)

Paralogs for ZNF524 Gene

Paralogs for ZNF524 Gene

(12) SIMAP similar genes for ZNF524 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF524: view

Variants for ZNF524 Gene

Sequence variations from dbSNP and Humsavar for ZNF524 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000260260 -- 55,597,958(+) C/G upstream_transcript_variant
rs1001635941 -- 55,598,591(+) T/C upstream_transcript_variant
rs1001729206 -- 55,598,347(+) C/G upstream_transcript_variant
rs1001783282 -- 55,598,025(+) C/T upstream_transcript_variant
rs1002186086 -- 55,599,797(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF524 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF524 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF524 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF524 Gene

Disorders for ZNF524 Gene

Additional Disease Information for ZNF524

No disorders were found for ZNF524 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF524 Gene

Publications for ZNF524 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 58

Products for ZNF524 Gene

Sources for ZNF524 Gene

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