Aliases for ZNF521 Gene
External Ids for ZNF521 Gene
Previous GeneCards Identifiers for ZNF521 Gene
GeneCards Summary for ZNF521 Gene
ZNF521 (Zinc Finger Protein 521) is a Protein Coding gene. Diseases associated with ZNF521 include Invasive Bladder Transitional Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein domain specific binding. An important paralog of this gene is ZNF423.
UniProtKB/Swiss-Prot Summary for ZNF521 Gene
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.