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Aliases for ZNF519 Gene

Aliases for ZNF519 Gene

  • Zinc Finger Protein 519 2 3 3 5
  • Similar To Zinc Finger Protein 85 (Zinc Finger Protein HPF4) (HTF1) 2
  • HsT2362 3

External Ids for ZNF519 Gene

Previous GeneCards Identifiers for ZNF519 Gene

  • GC18M014094
  • GC18M014030
  • GC18M014108
  • GC18M014193
  • GC18M014404
  • GC18M014695
  • GC18M014956

Summaries for ZNF519 Gene

GeneCards Summary for ZNF519 Gene

ZNF519 (Zinc Finger Protein 519) is a Protein Coding gene. Diseases associated with ZNF519 include Nail Disorder, Nonsyndromic Congenital, 4 and Nail Disease. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF429.

UniProtKB/Swiss-Prot for ZNF519 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF519 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF519 Gene

Genomics for ZNF519 Gene

GeneHancer (GH) Regulatory Elements for ZNF519 Gene

Promoters and enhancers for ZNF519 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J014131 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 691.4 +0.2 190 1.8 PKNOX1 ATF1 SIN3A FEZF1 POLR2B ELK1 FOS ATF7 SP3 NFYC ZNF519 ENSG00000267356
GH18J013824 Promoter/Enhancer 1.5 FANTOM5 Ensembl 16.8 +308.3 308289 0.4 HDGF RB1 ZNF133 KLF14 ZNF2 KLF5 ZBTB7B ZNF48 RAD21 ZNF335 MC5R ZNF519 ENSG00000267756 CEP192 PTPN2 RNMT GC18M015671
GH18J013445 Enhancer 0.8 Ensembl dbSUPER 12.9 +687.0 686989 0.6 ZSCAN4 PLRG1 ZFHX2 NONO NFATC1 IKZF1 PHB2 KLF9 ZNF207 ZNF24 PTPN2 PSMG2 ZNF519 ENSG00000266969 ENSG00000267756 HMGB3P28 GC18P013454 LDLRAD4-AS1 LDLRAD4
GH18J014025 Enhancer 0.2 ENCODE 15.6 +106.5 106477 1.3 ZNF519 ENSG00000279352 LOC100128776
GH18J013307 Enhancer 0.4 dbSUPER 4.4 +823.4 823439 2.4 IKZF1 IKZF2 LDLRAD4 ZNF519 PIR43692 ENSG00000279275
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF519 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF519 gene promoter:
  • GATA-1
  • SRF (504 AA)
  • SRF
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • XBP-1
  • C/EBPalpha
  • SREBP-1a
  • SREBP-1b

Genomic Locations for ZNF519 Gene

Genomic Locations for ZNF519 Gene
chr18:14,056,324-14,132,490
(GRCh38/hg38)
Size:
76,167 bases
Orientation:
Minus strand
chr18:14,057,456-14,132,489
(GRCh37/hg19)
Size:
75,034 bases
Orientation:
Minus strand

Genomic View for ZNF519 Gene

Genes around ZNF519 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF519 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF519 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF519 Gene

Proteins for ZNF519 Gene

  • Protein details for ZNF519 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB69-ZN519_HUMAN
    Recommended name:
    Zinc finger protein 519
    Protein Accession:
    Q8TB69

    Protein attributes for ZNF519 Gene

    Size:
    540 amino acids
    Molecular mass:
    63020 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF519 Gene

Post-translational modifications for ZNF519 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF519 Gene

Domains & Families for ZNF519 Gene

Gene Families for ZNF519 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF519 Gene

Suggested Antigen Peptide Sequences for ZNF519 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TB69

UniProtKB/Swiss-Prot:

ZN519_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF519: view

Function for ZNF519 Gene

Molecular function for ZNF519 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF519: view
genes like me logo Genes that share phenotypes with ZNF519: view

Animal Model Products

Targeted motifs for ZNF519 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF519
  • Consensus sequence: GAGSCCGAGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF519 Gene

Localization for ZNF519 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF519 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF519 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF519: view

Pathways & Interactions for ZNF519 Gene

SuperPathways for ZNF519 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF519: view

Pathways by source for ZNF519 Gene

2 Reactome pathways for ZNF519 Gene

Interacting Proteins for ZNF519 Gene

Gene Ontology (GO) - Biological Process for ZNF519 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF519: view

No data available for SIGNOR curated interactions for ZNF519 Gene

Drugs & Compounds for ZNF519 Gene

No Compound Related Data Available

Transcripts for ZNF519 Gene

Unigene Clusters for ZNF519 Gene

Zinc finger protein 519:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF519 Gene

No ASD Table

Relevant External Links for ZNF519 Gene

GeneLoc Exon Structure for
ZNF519
ECgene alternative splicing isoforms for
ZNF519

Expression for ZNF519 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF519 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF519 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for ZNF519 Gene

This gene is overexpressed in Ovary (54.9) and Skin (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF519 Gene



Protein tissue co-expression partners for ZNF519 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF519 Gene:

ZNF519

SOURCE GeneReport for Unigene cluster for ZNF519 Gene:

Hs.352635
genes like me logo Genes that share expression patterns with ZNF519: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF519 Gene

Orthologs for ZNF519 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF519 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF519 34 33
  • 99.44 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp386 33
  • 63 (n)
mouse
(Mus musculus)
Mammalia Zfp386 16 33
  • 61.79 (n)
Zfp493 34
  • 53 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF519 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF519 Gene

ENSEMBL:
Gene Tree for ZNF519 (if available)
TreeFam:
Gene Tree for ZNF519 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF519: view image

Paralogs for ZNF519 Gene

(514) SIMAP similar genes for ZNF519 Gene using alignment to 3 proteins:

  • ZN519_HUMAN
  • K7EJG2_HUMAN
  • K7ERG6_HUMAN
genes like me logo Genes that share paralogs with ZNF519: view

Variants for ZNF519 Gene

Sequence variations from dbSNP and Humsavar for ZNF519 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000087348 -- 14,116,403(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000115420 -- 14,077,479(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000247423 -- 14,083,491(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000260586 -- 14,079,649(-) AAAA/AAA genic_downstream_transcript_variant, intron_variant
rs1000339823 -- 14,109,833(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF519 Gene

Variant ID Type Subtype PubMed ID
nsv978609 CNV duplication 23825009
nsv978608 CNV duplication 23825009
nsv962493 CNV duplication 23825009
nsv828187 CNV gain 20364138
nsv828185 CNV gain 20364138
nsv576531 CNV gain 21841781
nsv576529 CNV gain 21841781
nsv528944 CNV loss 19592680
nsv520945 CNV loss 19592680
nsv516839 CNV loss 19592680
nsv1066142 CNV loss 25217958
nsv1061483 CNV loss 25217958
esv994375 CNV loss 20482838
esv3641872 CNV loss 21293372
esv3555094 CNV deletion 23714750
esv2760500 CNV loss 21179565
esv2758715 CNV gain 17122850
esv27400 CNV gain 19812545
dgv602e214 CNV loss 21293372
dgv3322n100 CNV loss 25217958
dgv3321n100 CNV loss 25217958

Variation tolerance for ZNF519 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF519 Gene

Human Gene Mutation Database (HGMD)
ZNF519
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF519

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF519 Gene

Disorders for ZNF519 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF519 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
nail disorder, nonsyndromic congenital, 4
  • ndnc4
nail disease
  • abnormality of the nail
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF519

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF519: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF519 Gene

Publications for ZNF519 Gene

  1. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S … Hardiman O (European journal of human genetics : EJHG 2009) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF519 Gene

Sources for ZNF519 Gene

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