Aliases for ZNF518B Gene

Aliases for ZNF518B Gene

  • Zinc Finger Protein 518B 2 3 4 5
  • KIAA1729 2 4
  • ZNF518B 5

External Ids for ZNF518B Gene

Previous GeneCards Identifiers for ZNF518B Gene

  • GC04M010050
  • GC04M009775

Summaries for ZNF518B Gene

GeneCards Summary for ZNF518B Gene

ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF518A.

UniProtKB/Swiss-Prot Summary for ZNF518B Gene

Additional gene information for ZNF518B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF518B Gene

Genomics for ZNF518B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF518B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF518B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF518B

Top Transcription factor binding sites by QIAGEN in the ZNF518B gene promoter:
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3

Genomic Locations for ZNF518B Gene

Genomic Locations for ZNF518B Gene
chr4:10,439,880-10,457,426
(GRCh38/hg38)
Size:
17,547 bases
Orientation:
Minus strand
chr4:10,441,498-10,459,034
(GRCh37/hg19)
Size:
17,537 bases
Orientation:
Minus strand

Genomic View for ZNF518B Gene

Genes around ZNF518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518B Gene

Proteins for ZNF518B Gene

  • Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D4-Z518B_HUMAN
    Recommended name:
    Zinc finger protein 518B
    Protein Accession:
    Q9C0D4
    Secondary Accessions:
    • Q96LN8

    Protein attributes for ZNF518B Gene

    Size:
    1074 amino acids
    Molecular mass:
    119531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF518B Gene

Post-translational modifications for ZNF518B Gene

  • Ubiquitination at Lys68, Lys76, Lys414, Lys508, Lys875, Lys912, and Lys1004
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518B Gene

No data available for DME Specific Peptides for ZNF518B Gene

Domains & Families for ZNF518B Gene

Gene Families for ZNF518B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF518B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF518B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 518B (Z518B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C0D4

UniProtKB/Swiss-Prot:

Z518B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF518B: view

Function for ZNF518B Gene

Molecular function for ZNF518B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF518B Gene

Gene Ontology (GO) - Molecular Function for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

Phenotypes for ZNF518B Gene

genes like me logo Genes that share phenotypes with ZNF518B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF518B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518B Gene

Localization for ZNF518B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF518B gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF518B: view

Pathways & Interactions for ZNF518B Gene

PathCards logo

SuperPathways for ZNF518B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF518B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF518B Gene

Drugs & Compounds for ZNF518B Gene

No Compound Related Data Available

Transcripts for ZNF518B Gene

mRNA/cDNA for ZNF518B Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF518B

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518B Gene

No ASD Table

Relevant External Links for ZNF518B Gene

GeneLoc Exon Structure for
ZNF518B

Expression for ZNF518B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF518B Gene

Protein differential expression in normal tissues from HIPED for ZNF518B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF518B Gene



Protein tissue co-expression partners for ZNF518B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF518B

SOURCE GeneReport for Unigene cluster for ZNF518B Gene:

Hs.455089

Evidence on tissue expression from TISSUES for ZNF518B Gene

  • Adrenal gland(2.1)
  • Lung(2.1)
  • Skin(2.1)
  • Nervous system(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZNF518B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF518B Gene

Orthologs for ZNF518B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF518B 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF518B 30 31
  • 84.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF518B 30 31
  • 79.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp518b 30
  • 75.94 (n)
Mouse
(Mus musculus)
Mammalia Zfp518b 30 17 31
  • 75.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF518B 31
  • 42 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF518B 31
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF518B 30 31
  • 58.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF518B 31
  • 14 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15195 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.16698 30
Zebrafish
(Danio rerio)
Actinopterygii ZNF518B 31
  • 19 (a)
OneToOne
Species where no ortholog for ZNF518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF518B Gene

ENSEMBL:
Gene Tree for ZNF518B (if available)
TreeFam:
Gene Tree for ZNF518B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF518B: view image

Paralogs for ZNF518B Gene

Variants for ZNF518B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF518B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs10007352 - p.Gly92Ser
rs10016702 - p.Ser105Pro
rs9291410 - p.Ser523Asn

Additional dbSNP identifiers (rs#s) for ZNF518B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF518B Gene

Variant ID Type Subtype PubMed ID
esv2759223 CNV loss 17122850
esv3599589 CNV gain 21293372
esv3599622 CNV gain 21293372
esv3893876 CNV gain 25118596
esv3893877 CNV loss 25118596
nsv1014335 CNV gain 25217958
nsv1122083 CNV deletion 24896259
nsv517971 CNV gain 19592680
nsv593727 CNV gain 21841781
nsv829858 CNV gain+loss 17160897

Variation tolerance for ZNF518B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF518B Gene

Human Gene Mutation Database (HGMD)
ZNF518B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene

Disorders for ZNF518B Gene

Additional Disease Information for ZNF518B

No disorders were found for ZNF518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518B Gene

Publications for ZNF518B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3

Products for ZNF518B Gene

Sources for ZNF518B Gene