Aliases for ZNF518B Gene
External Ids for ZNF518B Gene
- HGNC: 29365
- Entrez Gene: 85460
- Ensembl: ENSG00000178163
- OMIM: 617734
- UniProtKB: Q9C0D4
Previous GeneCards Identifiers for ZNF518B Gene
- GC04M010050
- GC04M009775
Summaries for ZNF518B Gene
GeneCards Summary for ZNF518B Gene
ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF518A.
UniProtKB/Swiss-Prot for ZNF518B Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF518B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518B Gene
Genomics for ZNF518B Gene
GeneHancer (GH) Regulatory Elements for ZNF518B Gene
Promoters and enhancers for ZNF518B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF518B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF518B Gene
Genomic Locations for ZNF518B Gene
- chr4:10,439,873-10,457,410
- (GRCh38/hg38)
- Size:
- 17,538 bases
- Orientation:
- Minus strand
- chr4:10,441,498-10,459,034
- (GRCh37/hg19)
Genomic View for ZNF518B Gene
Genes around ZNF518B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Ensembl
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
ZNF518B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF518B Gene
Proteins for ZNF518B Gene
-
Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0D4-Z518B_HUMAN
- Recommended name:
- Zinc finger protein 518B
- Protein Accession:
- Q9C0D4
- Q96LN8
Protein attributes for ZNF518B Gene
- Size:
- 1074 amino acids
- Molecular mass:
- 119531 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF518B Gene
Post-translational modifications for ZNF518B Gene
Other Protein References for ZNF518B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF518B
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- antibodies-online: Search results for 4 available ZNF518B Antibodies ranked by validation data
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for ZNF518B Gene
Domains & Families for ZNF518B Gene
Gene Families for ZNF518B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF518B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF518B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9C0D4- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF518B Gene
Molecular function for ZNF518B Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF518B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF518B Gene
- GenomeRNAi human phenotypes for ZNF518B:
Animal Model Products
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-
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for ZNF518B Gene
- miRTarBase miRNAs that target ZNF518B
-
- hsa-mir-6875-3p (MIRT407995)
- hsa-mir-4659b-3p (MIRT651059)
- hsa-mir-4659a-3p (MIRT651060)
- hsa-mir-4279 (MIRT651061)
- hsa-mir-7111-3p (MIRT651062)
- hsa-mir-6794-3p (MIRT651063)
- hsa-mir-627-3p (MIRT651064)
- hsa-mir-6837-3p (MIRT651065)
- hsa-mir-6754-3p (MIRT651066)
- hsa-mir-412-3p (MIRT651067)
- hsa-mir-6845-3p (MIRT651068)
- hsa-mir-6769b-3p (MIRT651069)
- hsa-mir-4723-3p (MIRT651070)
- hsa-mir-3183 (MIRT651071)
- hsa-mir-483-3p (MIRT651072)
- hsa-mir-3613-3p (MIRT651073)
- hsa-mir-140-3p (MIRT651074)
- hsa-mir-497-3p (MIRT651075)
- hsa-mir-548t-3p (MIRT651076)
- hsa-mir-548ap-3p (MIRT651077)
- hsa-mir-548aa (MIRT651078)
- hsa-mir-548z (MIRT651079)
- hsa-mir-548h-3p (MIRT651080)
- hsa-mir-548d-3p (MIRT651081)
- hsa-mir-548bb-3p (MIRT651082)
- hsa-mir-548ac (MIRT651083)
- hsa-mir-4764-5p (MIRT723447)
- hsa-mir-8064 (MIRT723448)
- hsa-mir-4698 (MIRT723449)
- hsa-mir-4694-3p (MIRT723450)
miRNA Products
- Search ViGene Biosciences for ZNF518B
Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF518B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF518B gene related products
- orf clones - Search results for available ZNF518B gene related products
- Applied Biological Materials Clones for ZNF518B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF518B
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF518B gene
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ViGene Biosciences ready-to-package AAV shRNAs for ZNF518B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518B Gene
Localization for ZNF518B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
Pathways & Interactions for ZNF518B Gene
No Data Available
Interacting Proteins for ZNF518B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF518B Gene
Transcripts for ZNF518B Gene
mRNA/cDNA for ZNF518B Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (98) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF518B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF518B
- genomics-online: gRNA clones - Search results for available ZNF518B gene related products
- Applied Biological Materials CRISPR for ZNF518B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF518B
- GenScript: Design CRISPR guide RNA sequences for ZNF518B
miRNA Products
- Search ViGene Biosciences for ZNF518B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNF518B
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- genomics-online: shRNA clones - Search results for available ZNF518B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF518B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF518B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF518B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF518B gene related products
- orf clones - Search results for available ZNF518B gene related products
- Applied Biological Materials Clones for ZNF518B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZNF518B Gene
This gene is overexpressed in Plasma (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF518B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF518B Gene:
ZNF518BSOURCE GeneReport for Unigene cluster for ZNF518B Gene:
Hs.455089Evidence on tissue expression from TISSUES for ZNF518B Gene
- Adrenal gland(2.1)
- Lung(2.1)
- Skin(2.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for ZNF518B
- genomics-online: primer clones - Search results for available ZNF518B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF518B Gene
Orthologs for ZNF518B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF518B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF518B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF518B 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp518b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp518b 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF518B 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZNF518B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF518B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNF518B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.16698 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15195 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ZNF518B 34 |
|
OneToOne |
- Species where no ortholog for ZNF518B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF518B Gene
Variants for ZNF518B Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000056824 | -- | 10,442,822(-) | A/C | 3_prime_UTR_variant | |
| rs1000076579 | -- | 10,452,221(-) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000151484 | -- | 10,443,468(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000182371 | -- | 10,446,201(-) | A/T | coding_sequence_variant, missense_variant | |
| rs1000286419 | -- | 10,440,645(-) | T/C | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759223 | CNV | loss | 17122850 |
| esv3599589 | CNV | gain | 21293372 |
| esv3599622 | CNV | gain | 21293372 |
| esv3893876 | CNV | gain | 25118596 |
| esv3893877 | CNV | loss | 25118596 |
| nsv1014335 | CNV | gain | 25217958 |
| nsv1122083 | CNV | deletion | 24896259 |
| nsv517971 | CNV | gain | 19592680 |
| nsv593727 | CNV | gain | 21841781 |
| nsv829858 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.57;
77.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF518B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene
Disorders for ZNF518B Gene
Additional Disease Information for ZNF518B
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZNF518B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518B Gene
Publications for ZNF518B Gene
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells. (PMID: 27805251) Riffo-Campos ÁL … Franco L (Oncology reports 2016) 3 58
Products for ZNF518B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available ZNF518B Antibodies ranked by validation data
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- antibodies-online: Search results for available ZNF518B related products ranked by validation data
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Sources for ZNF518B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems