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Aliases for ZNF518B Gene

Aliases for ZNF518B Gene

  • Zinc Finger Protein 518B 2 3 5
  • KIAA1729 4

External Ids for ZNF518B Gene

Previous GeneCards Identifiers for ZNF518B Gene

  • GC04M010050
  • GC04M009775

Summaries for ZNF518B Gene

GeneCards Summary for ZNF518B Gene

ZNF518B (Zinc Finger Protein 518B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF518A.

UniProtKB/Swiss-Prot for ZNF518B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF518B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518B Gene

Genomics for ZNF518B Gene

GeneHancer (GH) Regulatory Elements for ZNF518B Gene

Promoters and enhancers for ZNF518B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I010456 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.1 +0.3 281 1.7 HDAC1 HDGF ATF1 RB1 NFRKB SIN3A KLF5 YY1 ZNF335 ZNF213 ZNF518B LOC105374482
GH04I010167 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +285.3 285305 8.5 HDGF PKNOX1 CLOCK SMAD1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 SLC2A9 ZNF518B ENSG00000261490 LOC105374476 ENSG00000251296 LOC100129344
GH04I010203 Enhancer 1.1 ENCODE dbSUPER 13.6 +253.0 253002 1.6 HDGF ATF1 ZNF766 CBX5 GATA2 ATF7 NCOA1 ZNF592 MBD2 GMEB1 SLC2A9 ZNF518B ENSG00000261490 LOC100129344 ENSG00000271544
GH04I010281 Enhancer 0.8 ENCODE 14.6 +173.7 173711 4.2 HDAC1 MEIS2 PKNOX1 TEAD4 JUN FOSL1 TCF12 CTBP1 GATA2 NCOR1 ZNF518B SLC2A9 ENSG00000261490 LOC100422637 ENSG00000250074
GH04I010344 Enhancer 1 FANTOM5 ENCODE 11.4 +111.5 111452 2 HDAC1 PKNOX1 SMAD1 TCF12 ZNF766 GATA2 ATF7 ZBTB11 NCOA1 ZEB2 SLC2A9 ZNF518B GC04M010387 LOC100422639
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF518B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF518B gene promoter:

Genomic Locations for ZNF518B Gene

Genomic Locations for ZNF518B Gene
17,538 bases
Minus strand

Genomic View for ZNF518B Gene

Genes around ZNF518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518B Gene

Proteins for ZNF518B Gene

  • Protein details for ZNF518B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 518B
    Protein Accession:
    Secondary Accessions:
    • Q96LN8

    Protein attributes for ZNF518B Gene

    1074 amino acids
    Molecular mass:
    119531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF518B Gene

Post-translational modifications for ZNF518B Gene

  • Ubiquitination at posLast=6868, isoforms=414, posLast=508508, posLast=875875, isoforms=912, and posLast=10041004
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF518B Gene

No data available for DME Specific Peptides for ZNF518B Gene

Domains & Families for ZNF518B Gene

Gene Families for ZNF518B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF518B Gene

Suggested Antigen Peptide Sequences for ZNF518B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF518B: view

Function for ZNF518B Gene

Molecular function for ZNF518B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF518B Gene

Gene Ontology (GO) - Molecular Function for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

Phenotypes for ZNF518B Gene

GenomeRNAi human phenotypes for ZNF518B:
genes like me logo Genes that share phenotypes with ZNF518B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518B Gene

Localization for ZNF518B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF518B gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF518B: view

Pathways & Interactions for ZNF518B Gene

SuperPathways for ZNF518B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF518B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF518B Gene

Drugs & Compounds for ZNF518B Gene

No Compound Related Data Available

Transcripts for ZNF518B Gene

Unigene Clusters for ZNF518B Gene

Zinc finger protein 518B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518B Gene

No ASD Table

Relevant External Links for ZNF518B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF518B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF518B Gene

Protein differential expression in normal tissues from HIPED for ZNF518B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF518B Gene

Protein tissue co-expression partners for ZNF518B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF518B Gene:


SOURCE GeneReport for Unigene cluster for ZNF518B Gene:


Evidence on tissue expression from TISSUES for ZNF518B Gene

  • Adrenal gland(2.1)
  • Lung(2.1)
  • Skin(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNF518B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF518B Gene

Orthologs for ZNF518B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF518B 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia ZNF518B 33 34
  • 84.84 (n)
(Bos Taurus)
Mammalia ZNF518B 33 34
  • 79.2 (n)
(Rattus norvegicus)
Mammalia Zfp518b 33
  • 75.94 (n)
(Mus musculus)
Mammalia Zfp518b 33 16 34
  • 75.87 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF518B 34
  • 42 (a)
(Monodelphis domestica)
Mammalia ZNF518B 34
  • 41 (a)
(Gallus gallus)
Aves ZNF518B 33 34
  • 58.49 (n)
(Anolis carolinensis)
Reptilia ZNF518B 34
  • 14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16698 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15195 33
(Danio rerio)
Actinopterygii ZNF518B 34
  • 19 (a)
Species where no ortholog for ZNF518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF518B Gene

Gene Tree for ZNF518B (if available)
Gene Tree for ZNF518B (if available)

Paralogs for ZNF518B Gene

Paralogs for ZNF518B Gene

genes like me logo Genes that share paralogs with ZNF518B: view

Variants for ZNF518B Gene

Sequence variations from dbSNP and Humsavar for ZNF518B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000056824 -- 10,442,822(-) A/C 3_prime_UTR_variant
rs1000076579 -- 10,452,221(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000151484 -- 10,443,468(-) G/A coding_sequence_variant, missense_variant
rs1000182371 -- 10,446,201(-) A/T coding_sequence_variant, missense_variant
rs1000286419 -- 10,440,645(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF518B Gene

Variant ID Type Subtype PubMed ID
esv2759223 CNV loss 17122850
esv3599589 CNV gain 21293372
esv3599622 CNV gain 21293372
esv3893876 CNV gain 25118596
esv3893877 CNV loss 25118596
nsv1014335 CNV gain 25217958
nsv1122083 CNV deletion 24896259
nsv517971 CNV gain 19592680
nsv593727 CNV gain 21841781
nsv829858 CNV gain+loss 17160897

Variation tolerance for ZNF518B Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF518B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF518B Gene

Disorders for ZNF518B Gene

Additional Disease Information for ZNF518B

No disorders were found for ZNF518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518B Gene

Publications for ZNF518B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells. (PMID: 27805251) Riffo-Campos ÁL … Franco L (Oncology reports 2016) 3 58

Products for ZNF518B Gene

Sources for ZNF518B Gene

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