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Aliases for ZNF518A Gene

Aliases for ZNF518A Gene

  • Zinc Finger Protein 518A 2 3 3 5
  • Zinc Finger Protein 518 2 3
  • ZNF518 3 4
  • KIAA0335 4

External Ids for ZNF518A Gene

Previous HGNC Symbols for ZNF518A Gene

  • ZNF518

Previous GeneCards Identifiers for ZNF518A Gene

  • GC10P097880
  • GC10P091517

Summaries for ZNF518A Gene

Entrez Gene Summary for ZNF518A Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]

GeneCards Summary for ZNF518A Gene

ZNF518A (Zinc Finger Protein 518A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF518B.

UniProtKB/Swiss-Prot for ZNF518A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF518A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF518A Gene

Genomics for ZNF518A Gene

GeneHancer (GH) Regulatory Elements for ZNF518A Gene

Promoters and enhancers for ZNF518A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096128 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 682.9 +1.3 1257 3.3 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF518A GC10M096129 CCNJ LCOR NPM1P26 TCTN3 RPL13AP5 TM9SF3 SLIT1-AS1 ENTPD1-AS1
GH10J096579 Enhancer 1.4 Ensembl ENCODE dbSUPER 83 +451.8 451797 2.7 FEZF1 GLI4 ZNF2 YY1 ZNF121 ZNF416 KLF7 ZNF548 ATF7 KLF13 ZNF518A TCTN3 MMS19 CCNJ LCOR EXOSC1 NPM1P26 TM9SF3 MIR607 ALDH18A1
GH10J095654 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 31 -473.3 -473257 3 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ALDH18A1 ZNF518A TCTN3 CCNJ ENTPD1 PIR60482
GH10J095286 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24 -837.0 -836986 11.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 IRF4 YY1 ZNF213 ZNF207 PDLIM1 CCNJ ZNF518A TCTN3 NOC3L HELLS ENSG00000273450 TBC1D12 CYP2C8 ENTPD1
GH10J096088 Promoter/Enhancer 1.6 Ensembl ENCODE 26 -39.4 -39353 2.2 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF610 ENTPD1-AS1 TCTN3 ZNF518A RPL13AP5 NPM1P26 CCNJ RNU6-271P LCOR TM9SF3 CC2D2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF518A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF518A gene promoter:
  • GATA-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for ZNF518A Gene

Genomic Locations for ZNF518A Gene
chr10:96,129,200-96,205,288
(GRCh38/hg38)
Size:
76,089 bases
Orientation:
Plus strand
chr10:97,889,472-97,965,044
(GRCh37/hg19)
Size:
75,573 bases
Orientation:
Plus strand

Genomic View for ZNF518A Gene

Genes around ZNF518A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF518A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF518A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF518A Gene

Proteins for ZNF518A Gene

  • Protein details for ZNF518A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AHZ1-Z518A_HUMAN
    Recommended name:
    Zinc finger protein 518A
    Protein Accession:
    Q6AHZ1
    Secondary Accessions:
    • A0PJI5
    • O15044
    • Q32MP4

    Protein attributes for ZNF518A Gene

    Size:
    1483 amino acids
    Molecular mass:
    166782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20793.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF518A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF518A Gene

Post-translational modifications for ZNF518A Gene

  • Ubiquitination at posLast=14381438, isoforms=21121, and isoforms=433
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF518A Gene

Domains & Families for ZNF518A Gene

Gene Families for ZNF518A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF518A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF518A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AHZ1

UniProtKB/Swiss-Prot:

Z518A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF518A: view

Function for ZNF518A Gene

Molecular function for ZNF518A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF518A Gene

Gene Ontology (GO) - Molecular Function for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

Phenotypes for ZNF518A Gene

genes like me logo Genes that share phenotypes with ZNF518A: view

Animal Model Products

miRNA for ZNF518A Gene

miRTarBase miRNAs that target ZNF518A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF518A Gene

Localization for ZNF518A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF518A Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF518A: view

No data available for Subcellular locations from COMPARTMENTS for ZNF518A Gene

Pathways & Interactions for ZNF518A Gene

SuperPathways for ZNF518A Gene

No Data Available

Interacting Proteins for ZNF518A Gene

Gene Ontology (GO) - Biological Process for ZNF518A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF518A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF518A Gene

Drugs & Compounds for ZNF518A Gene

No Compound Related Data Available

Transcripts for ZNF518A Gene

Unigene Clusters for ZNF518A Gene

Zinc finger protein 518A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF518A Gene

No ASD Table

Relevant External Links for ZNF518A Gene

GeneLoc Exon Structure for
ZNF518A
ECgene alternative splicing isoforms for
ZNF518A

Expression for ZNF518A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF518A Gene

Protein differential expression in normal tissues from HIPED for ZNF518A Gene

This gene is overexpressed in Bone (33.5), Plasma (19.5), and Prostate (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF518A Gene



Protein tissue co-expression partners for ZNF518A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF518A Gene:

ZNF518A

SOURCE GeneReport for Unigene cluster for ZNF518A Gene:

Hs.600823
genes like me logo Genes that share expression patterns with ZNF518A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF518A Gene

Orthologs for ZNF518A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF518A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF518A 33
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ZNF518A 33
  • 90.1 (n)
cow
(Bos Taurus)
Mammalia ZNF518A 33
  • 87.86 (n)
mouse
(Mus musculus)
Mammalia Zfp518a 16 33
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Zfp518a 33
  • 80.45 (n)
chicken
(Gallus gallus)
Aves ZNF518A 33
  • 61.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf518a 33
  • 56.48 (n)
Species where no ortholog for ZNF518A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF518A Gene

ENSEMBL:
Gene Tree for ZNF518A (if available)
TreeFam:
Gene Tree for ZNF518A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF518A: view image

Paralogs for ZNF518A Gene

Paralogs for ZNF518A Gene

(2) SIMAP similar genes for ZNF518A Gene using alignment to 1 proteins:

  • Z518A_HUMAN
genes like me logo Genes that share paralogs with ZNF518A: view

Variants for ZNF518A Gene

Sequence variations from dbSNP and Humsavar for ZNF518A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000186040 -- 96,142,644(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000226127 -- 96,133,408(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000255807 -- 96,133,116(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000348200 -- 96,164,079(+) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000529603 -- 96,127,708(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF518A Gene

Variant ID Type Subtype PubMed ID
nsv831947 CNV gain+loss 17160897
nsv1134043 CNV deletion 24896259
nsv1110852 OTHER inversion 24896259
esv3579082 CNV loss 25503493

Additional Variant Information for ZNF518A Gene

Human Gene Mutation Database (HGMD)
ZNF518A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF518A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF518A Gene

Disorders for ZNF518A Gene

Additional Disease Information for ZNF518A

No disorders were found for ZNF518A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF518A Gene

Publications for ZNF518A Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF518A Gene

Sources for ZNF518A Gene

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