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Aliases for ZNF517 Gene

Aliases for ZNF517 Gene

  • Zinc Finger Protein 517 2 3 3 5

External Ids for ZNF517 Gene

Previous GeneCards Identifiers for ZNF517 Gene

  • GC08P146029
  • GC08P145995
  • GC08P146024
  • GC08P141139

Summaries for ZNF517 Gene

GeneCards Summary for ZNF517 Gene

ZNF517 (Zinc Finger Protein 517) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is KRBOX1.

UniProtKB/Swiss-Prot for ZNF517 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF517 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF517 Gene

Genomics for ZNF517 Gene

GeneHancer (GH) Regulatory Elements for ZNF517 Gene

Promoters and enhancers for ZNF517 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J144796 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 664.5 +0.1 107 5 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF207 ZNF143 ZNF263 SP3 ZNF517 ZNF7 VPS28 CPSF1 RPL8 ZNF250 LRRC14 ZNF251 GPAA1 ADCK5
GH08J144544 Promoter 0.5 EPDnew 650.1 -254.6 -254607 0.1 ZNF517 C8orf82 ENSG00000255456 ARHGAP39
GH08J144455 Enhancer 1.3 Ensembl ENCODE 72.2 -342.4 -342430 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 YY1 POLR2B ZNF251 ZNF7 ZNF623 LRRC14 ZNF250 CPSF1 ZNF16 VPS28 ZNF517 GPAA1
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.8 -695.0 -694965 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF251 ZNF250 ZNF517 CPSF1 ZNF696
GH08J144425 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.6 -369.9 -369937 6.8 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B VPS28 TONSL CPSF1 ZNF517 SLC39A4 ZNF7 ZNF623 ZNF250 ZNF251 ZNF34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF517 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF517 gene promoter:
  • TBP
  • Pax-3
  • NRF-2
  • C/EBPalpha
  • FAC1
  • N-Myc

Genomic Locations for ZNF517 Gene

Genomic Locations for ZNF517 Gene
12,294 bases
Plus strand
12,294 bases
Plus strand

Genomic View for ZNF517 Gene

Genes around ZNF517 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF517 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF517 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF517 Gene

Proteins for ZNF517 Gene

  • Protein details for ZNF517 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 517
    Protein Accession:

    Protein attributes for ZNF517 Gene

    492 amino acids
    Molecular mass:
    54711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF517 Gene

Post-translational modifications for ZNF517 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF517 Gene

Domains & Families for ZNF517 Gene

Gene Families for ZNF517 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF517 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF517: view

Function for ZNF517 Gene

Molecular function for ZNF517 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF517 Gene

Gene Ontology (GO) - Molecular Function for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF517: view
genes like me logo Genes that share phenotypes with ZNF517: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF517 Gene

Localization for ZNF517 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF517 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF517 gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF517: view

Pathways & Interactions for ZNF517 Gene

SuperPathways for ZNF517 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF517: view

Pathways by source for ZNF517 Gene

2 Reactome pathways for ZNF517 Gene

Interacting Proteins for ZNF517 Gene

Gene Ontology (GO) - Biological Process for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF517: view

No data available for SIGNOR curated interactions for ZNF517 Gene

Drugs & Compounds for ZNF517 Gene

No Compound Related Data Available

Transcripts for ZNF517 Gene

mRNA/cDNA for ZNF517 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF517 Gene

Zinc finger protein 517:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF517 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - -

Relevant External Links for ZNF517 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF517 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF517 Gene

Protein differential expression in normal tissues from HIPED for ZNF517 Gene

This gene is overexpressed in Heart (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF517 Gene

Protein tissue co-expression partners for ZNF517 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF517 Gene:


SOURCE GeneReport for Unigene cluster for ZNF517 Gene:


Evidence on tissue expression from TISSUES for ZNF517 Gene

  • Liver(2)
genes like me logo Genes that share expression patterns with ZNF517: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF517 Gene

Orthologs for ZNF517 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF517 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF517 34 33
  • 98.49 (n)
(Canis familiaris)
Mammalia ZNF517 34 33
  • 80.59 (n)
Species where no ortholog for ZNF517 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF517 Gene

Gene Tree for ZNF517 (if available)
Gene Tree for ZNF517 (if available)
Evolutionary constrained regions (ECRs) for ZNF517: view image

Paralogs for ZNF517 Gene

Paralogs for ZNF517 Gene

(481) SIMAP similar genes for ZNF517 Gene using alignment to 7 proteins:

  • ZN517_HUMAN
  • A0AV05_HUMAN
  • G3V191_HUMAN
genes like me logo Genes that share paralogs with ZNF517: view

Variants for ZNF517 Gene

Sequence variations from dbSNP and Humsavar for ZNF517 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000065709 -- 144,801,787(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000100420 -- 144,806,074(+) T/C intron_variant
rs1000154023 -- 144,796,956(+) C/G upstream_transcript_variant
rs1000164496 -- 144,800,981(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000621377 -- 144,801,206(+) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF517 Gene

Variant ID Type Subtype PubMed ID
esv3573037 CNV loss 25503493
nsv522459 CNV loss 19592680
nsv523879 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for ZNF517 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF517 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF517 Gene

Disorders for ZNF517 Gene

Additional Disease Information for ZNF517

No disorders were found for ZNF517 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF517 Gene

Publications for ZNF517 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF517 Gene

Sources for ZNF517 Gene

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