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Aliases for ZNF517 Gene

Aliases for ZNF517 Gene

  • Zinc Finger Protein 517 2 3 5

External Ids for ZNF517 Gene

Previous GeneCards Identifiers for ZNF517 Gene

  • GC08P146029
  • GC08P145995
  • GC08P146024
  • GC08P141139

Summaries for ZNF517 Gene

GeneCards Summary for ZNF517 Gene

ZNF517 (Zinc Finger Protein 517) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP92.

UniProtKB/Swiss-Prot for ZNF517 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF517 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF517 Gene

Genomics for ZNF517 Gene

GeneHancer (GH) Regulatory Elements for ZNF517 Gene

Promoters and enhancers for ZNF517 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144796 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 556.1 +0.1 107 5 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF207 ZNF143 ZNF263 SP3 ZNF517 RPL8 CPSF1 ZNF7 VPS28 ZNF250 LRRC14 LOC105375803 ZNF34 PIR34635
GH08I144455 Enhancer 1.3 Ensembl ENCODE 72.2 -342.4 -342430 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.7 -695.0 -694965 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF696 ZNF517 ZNF251 ZNF250 CPSF1
GH08I143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24 -861.7 -861746 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 ZNF623 CPSF1 VPS28 LRRC14
GH08I144407 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24 -388.7 -388707 4.8 HDGF CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CPSF1 ENSG00000272115 ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 TMED10P1 ENSG00000255164 ZNF34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF517 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF517 gene promoter:

Genomic Locations for ZNF517 Gene

Genomic Locations for ZNF517 Gene
chr8:144,798,876-144,811,169
(GRCh38/hg38)
Size:
12,294 bases
Orientation:
Plus strand
chr8:146,024,261-146,036,554
(GRCh37/hg19)

Genomic View for ZNF517 Gene

Genes around ZNF517 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF517 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF517 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF517 Gene

Proteins for ZNF517 Gene

  • Protein details for ZNF517 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMY9-ZN517_HUMAN
    Recommended name:
    Zinc finger protein 517
    Protein Accession:
    Q6ZMY9

    Protein attributes for ZNF517 Gene

    Size:
    492 amino acids
    Molecular mass:
    54711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF517 Gene

Post-translational modifications for ZNF517 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF517 Gene

Domains & Families for ZNF517 Gene

Gene Families for ZNF517 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF517 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMY9

UniProtKB/Swiss-Prot:

ZN517_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF517: view

Function for ZNF517 Gene

Molecular function for ZNF517 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF517 Gene

Gene Ontology (GO) - Molecular Function for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF517: view
genes like me logo Genes that share phenotypes with ZNF517: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF517 Gene

Localization for ZNF517 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF517 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF517 gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF517: view

Pathways & Interactions for ZNF517 Gene

SuperPathways for ZNF517 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF517: view

Pathways by source for ZNF517 Gene

2 Reactome pathways for ZNF517 Gene

Interacting Proteins for ZNF517 Gene

Gene Ontology (GO) - Biological Process for ZNF517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF517: view

No data available for SIGNOR curated interactions for ZNF517 Gene

Drugs & Compounds for ZNF517 Gene

No Compound Related Data Available

Transcripts for ZNF517 Gene

Unigene Clusters for ZNF517 Gene

Zinc finger protein 517:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF517 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - -
SP5: -
SP6: - - - - - -

Relevant External Links for ZNF517 Gene

GeneLoc Exon Structure for
ZNF517
ECgene alternative splicing isoforms for
ZNF517

Expression for ZNF517 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF517 Gene

Protein differential expression in normal tissues from HIPED for ZNF517 Gene

This gene is overexpressed in Heart (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF517 Gene



Protein tissue co-expression partners for ZNF517 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF517 Gene:

ZNF517

SOURCE GeneReport for Unigene cluster for ZNF517 Gene:

Hs.521942

Evidence on tissue expression from TISSUES for ZNF517 Gene

  • Liver(2)
genes like me logo Genes that share expression patterns with ZNF517: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF517 Gene

Orthologs for ZNF517 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF517 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF517 33 34
  • 98.49 (n)
dog
(Canis familiaris)
Mammalia ZNF517 33 34
  • 80.59 (n)
Species where no ortholog for ZNF517 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF517 Gene

ENSEMBL:
Gene Tree for ZNF517 (if available)
TreeFam:
Gene Tree for ZNF517 (if available)

Paralogs for ZNF517 Gene

Paralogs for ZNF517 Gene

(481) SIMAP similar genes for ZNF517 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF517: view

Variants for ZNF517 Gene

Sequence variations from dbSNP and Humsavar for ZNF517 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000065709 -- 144,801,787(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000100420 -- 144,806,074(+) T/C intron_variant
rs1000154023 -- 144,796,956(+) C/G upstream_transcript_variant
rs1000164496 -- 144,800,981(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000621377 -- 144,801,206(+) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF517 Gene

Variant ID Type Subtype PubMed ID
nsv612969 CNV loss 21841781
nsv523879 CNV loss 19592680
nsv522459 CNV loss 19592680
esv3573037 CNV loss 25503493

Variation tolerance for ZNF517 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF517 Gene

Human Gene Mutation Database (HGMD)
ZNF517
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF517

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF517 Gene

Disorders for ZNF517 Gene

Additional Disease Information for ZNF517

No disorders were found for ZNF517 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF517 Gene

Publications for ZNF517 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF517 Gene

Sources for ZNF517 Gene

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