External Ids for ZNF516 Gene
Previous GeneCards Identifiers for ZNF516 Gene
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
GeneCards Summary for ZNF516 Gene
ZNF516 (Zinc Finger Protein 516) is a Protein Coding gene. Diseases associated with ZNF516 include Vertical Talus, Congenital and Chromosome 18Q Deletion Syndrome. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF536.
UniProtKB/Swiss-Prot Summary for ZNF516 Gene
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).