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Aliases for ZNF514 Gene

Aliases for ZNF514 Gene

  • Zinc Finger Protein 514 2 3 5

External Ids for ZNF514 Gene

Previous GeneCards Identifiers for ZNF514 Gene

  • GC02M095298
  • GC02M095235
  • GC02M095813
  • GC02M089842

Summaries for ZNF514 Gene

GeneCards Summary for ZNF514 Gene

ZNF514 (Zinc Finger Protein 514) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF713.

UniProtKB/Swiss-Prot for ZNF514 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF514 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF514 Gene

Genomics for ZNF514 Gene

GeneHancer (GH) Regulatory Elements for ZNF514 Gene

Promoters and enhancers for ZNF514 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I095164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.2 -0.2 -249 2.1 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF514 GC02M095163 ZNF2 PROM2 GC02M095170
GH02I095158 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.4 +5.9 5859 2.2 HDAC1 RB1 SIN3A DMAP1 ZBTB40 ZNF335 GLIS2 THAP11 SMAD5 ELF1 ZNF514 LOC101926959 MRPS5
GH02I095068 Enhancer 0.7 dbSUPER 66.6 +96.1 96051 2 ELF3 ZBTB21 ZFP64 ZNF140 ZNF266 THRB ZNF697 ZNF664 ZNF213 ZNF433 ZNF514 KCNIP3 ENSG00000233850 MAL ANKRD36C GPAT2P1 LOC105373488 ENSG00000231062
GH02I095206 Promoter/Enhancer 1.5 Ensembl ENCODE 26.5 -42.2 -42197 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF263 LOC344065 ZNF514 GPAT2P1 PIR51784 GC02P095217 GC02P095180
GH02I095120 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 +43.8 43807 2 HDGF CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MRPS5 ZNF514 LOC105373488
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF514 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF514 gene promoter:

Genomic Locations for ZNF514 Gene

Genomic Locations for ZNF514 Gene
chr2:95,130,110-95,165,413
(GRCh38/hg38)
Size:
35,304 bases
Orientation:
Minus strand
chr2:95,813,075-95,831,158
(GRCh37/hg19)

Genomic View for ZNF514 Gene

Genes around ZNF514 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF514 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF514 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF514 Gene

Proteins for ZNF514 Gene

  • Protein details for ZNF514 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K75-ZN514_HUMAN
    Recommended name:
    Zinc finger protein 514
    Protein Accession:
    Q96K75
    Secondary Accessions:
    • Q5JPJ3

    Protein attributes for ZNF514 Gene

    Size:
    400 amino acids
    Molecular mass:
    45938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF514 Gene

Post-translational modifications for ZNF514 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF514 Gene

No data available for DME Specific Peptides for ZNF514 Gene

Domains & Families for ZNF514 Gene

Gene Families for ZNF514 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF514 Gene

Suggested Antigen Peptide Sequences for ZNF514 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K75

UniProtKB/Swiss-Prot:

ZN514_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF514: view

Function for ZNF514 Gene

Molecular function for ZNF514 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF514 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF514: view
genes like me logo Genes that share phenotypes with ZNF514: view

miRNA for ZNF514 Gene

miRTarBase miRNAs that target ZNF514

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF514 Gene

Localization for ZNF514 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF514 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF514 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF514 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF514: view

Pathways & Interactions for ZNF514 Gene

SuperPathways for ZNF514 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF514: view

Pathways by source for ZNF514 Gene

2 Reactome pathways for ZNF514 Gene

Gene Ontology (GO) - Biological Process for ZNF514 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF514: view

No data available for SIGNOR curated interactions for ZNF514 Gene

Drugs & Compounds for ZNF514 Gene

No Compound Related Data Available

Transcripts for ZNF514 Gene

Unigene Clusters for ZNF514 Gene

Zinc finger protein 514:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF514 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5:
SP6:

Relevant External Links for ZNF514 Gene

GeneLoc Exon Structure for
ZNF514
ECgene alternative splicing isoforms for
ZNF514

Expression for ZNF514 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF514 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF514 Gene:

ZNF514

SOURCE GeneReport for Unigene cluster for ZNF514 Gene:

Hs.655109

Evidence on tissue expression from TISSUES for ZNF514 Gene

  • Lung(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZNF514: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF514 Gene

Orthologs for ZNF514 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF514 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF514 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia ZNF514 33 34
  • 87 (n)
cow
(Bos Taurus)
Mammalia ZNF514 33 34
  • 86.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 36
Species where no ortholog for ZNF514 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF514 Gene

ENSEMBL:
Gene Tree for ZNF514 (if available)
TreeFam:
Gene Tree for ZNF514 (if available)

Paralogs for ZNF514 Gene

Paralogs for ZNF514 Gene

(509) SIMAP similar genes for ZNF514 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF514 Gene

genes like me logo Genes that share paralogs with ZNF514: view

Variants for ZNF514 Gene

Sequence variations from dbSNP and Humsavar for ZNF514 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000134149 -- 95,163,057(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000146057 -- 95,122,835(-) C/T downstream_transcript_variant
rs1000244642 -- 95,155,946(-) G/T intron_variant
rs1000272010 -- 95,163,484(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000439063 -- 95,148,712(-) C/T 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF514 Gene

Variant ID Type Subtype PubMed ID
dgv4007n100 CNV gain 25217958
esv3591652 OTHER inversion 21293372
nsv1160825 CNV duplication 26073780

Variation tolerance for ZNF514 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF514 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF514

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF514 Gene

Disorders for ZNF514 Gene

Additional Disease Information for ZNF514

No disorders were found for ZNF514 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF514 Gene

Publications for ZNF514 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF514 Gene

Sources for ZNF514 Gene

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